Complete and high-resolution test method for motion characteristics of particles in turbid media

Abstract

The invention discloses a complete and high-resolution test method for the motion characteristics of particles in turbid media. The method comprises the following steps of: performing continuous, complete and real-time detection on the motion characteristics of the particles in the process of 'solution-colloid-sediment' of the turbid media by combining the resolution relation between the characteristic value of a speckle pattern and particle motion and utilizing a dynamic speckle test light path according to the particle light scattering theory; simultaneously, performing transient study on different critical points of the particle motion in the process by using a femtosecond laser test light path to perform the analysis of high spatial and temporal resolution on transient dynamics of the particles in the turbid media; and combining the two steps to realize the complete test with high spatial and temporal resolution characteristic on motion images of the particles in the process of 'solution-colloid-sediment' of the turbid media finally. The method is a non-contact, high-accuracy and real-time online detection method, has the characteristics that the operation is simple and the application range is wide, and can be widely used in the fields of medical science, pharmacy, chemical production and the like.

Description

technical field [0001] The invention relates to a complete and high-resolution testing method for moving images of turbid medium particles. Specifically, it involves a combination of dynamic speckle and femtosecond laser test light path to realize the complete test of particle motion characteristics in the process of "solution→colloid→precipitation" in turbid media and has the characteristics of ultra-high temporal and spatial resolution; The method has a wide detection range and high measurement accuracy, and is of great significance to the fields of medicine, pharmacy and chemical production. Background technique [0002] Turbid medium refers to a medium with non-uniform refractive index that can produce both scattering and absorption and is mainly caused by scattering; most chemical solutions and reagents contain a large number of scattering particles, which is a typical turbid medium. Therefore, the study of the motion characteristics of particles in the process of "sol...

AI Technical Summary

Problems solved by technology

After literature search, the U.S. patent "Two-dimensional imaging of translucent objects in turbid media" (authorization number US5644429A, authorization date 1997.07.01) provides a 4F Fourier optical imaging system to realize the imaging of translucent objects in turbid media solutions. The imaging method of translucent objects, which can realize the imaging of translucent objects, has the disadvantage that it cannot detect the movement process of a large number of particles in turbid solutions; the US patent "Method and device for characterization of particles in clear and turbid media" (authorization number is US 7528384B2, the date of authorization is 2009.05.05), which can realize the detection of the size, shape and concentration of fluorescent particles, but the measurement accuracy is low, and real-time measurement cannot be realized, which limits its application scope; the patent "a non-contact measurement solution Concentration device and method" (publication number is CN101430275A, publication date is 2009.05.13), its application object is non-scattering eye aqueous humor, the application range is very narrow, not universal; the patent "turbid medium particle size, concentration Changing dynamic speckle measurement method" (publication number CN101788448A, publication date is 2010.07.28), this method can realize the dynamic monitoring of particle size and concentration changes in the turbid medium at the same time, its shortcoming is that it does not realize the particle movement High resolution analysis of special nodes

[0003] It can be seen from the analysis that in the detection technology of particle movement characteristics of turbid medium solution, the main problem existing in the existing technology is: lack of continuous detection of particle movement characteristics in the process of "solution→colloid→precipitation" in turbid medium, and there is no (Molecular level), within a shorter time (femtosecond order), conduct microscopic research on the microscopic dynamic characteristics of the transient process of particles in turbid media; it has not achieved the completeness of the motion characteristics of particles in turbid media and has the characteristics of ultra-high resolution description of

Images