7 results about "Human bladder" patented technology

Bladder pressure measuring equipment comprises a liquid inlet device, the liquid inlet device comprises a liquid inlet pipe, one end of the liquid inlet pipe is connected with a first three-way pipe, the first three-way pipe is further connected with a pressure measuring device and an infusion device, the infusion device comprises an infusion pipe, and the pressure measuring device comprises a pressure measuring pipe with scale marks. The zero graduation line of the pressure measuring tube is kept consistent with the symphysis pubis horizontal plane of a patient, liquid flows through the infusion device from the liquid inlet device, then enters the bladder of the human body and then flows back to the pressure measuring device, measured values can be read by reading the horizontal height of the liquid in the pressure measuring tube, a pressure measuring ruler is not needed, operation steps are simplified, and working efficiency is improved. The reading accuracy is improved, and the department cost is reduced. The floating ball is arranged in the pressure measuring tube, the center of the floating ball is coplanar with the zero graduation line of the pressure measuring tube before liquid enters the pressure measuring tube, the floating ball can change along with the change of the horizontal plane of the liquid after the liquid enters the pressure measuring tube, and the pressure condition of the bladder of a patient can be known by observing the position of the floating ball.

The application belongs to the technical field of medicine preparation, and particularly relates to application of leaf alcohol in preparation of urinary system tumor medicine. Through animal experiment verification, the leaf alcohol has a significant improvement effect on tumors caused by human bladder cancer cells, and can be used for treatment of urinary system tumors. The application first determines that the leaf alcohol has an inhibitory effect on proliferation, migration ability and invasion ability of urinary system tumor cells.

The present application relates to the field of biotechnology, in particular to human bladder tissue digestion solution and application thereof.The digestion method of the present application can dissociate human bladder tissue cells while keeping the cell viability at more than 90%, and the amount of harvested cells is also obviously improved.Sufficient cell amount is the prerequisite for optimization treatment such as red blood cell lysis and dead cell removal.The single cell suspension obtained by the method has high viability, low clumping rate, high nucleated rate and less impurities, which can provide a basis for obtaining high-quality gene expression data in human bladder tissue single cell sequencing experiment.The present application can quickly obtain human bladder tissue primary cell suspension (sufficient cell amount, high viability, low clumping rate and less impurities) meeting the requirements of single cell experiment within 2-4 hours.

The present application relates to a kind of preparation of new indole camptothecin derivatives and its use in antitumor, the structure of the compound general formula is shown as follows.In vitro cytotoxic activity screening results show that new indole camptothecin derivatives have broad-spectrum antitumor activity, to human hepatoma cell (HepG2), human non-small cell lung cancer cell (A549), human colon cancer cell (SW480), human intrahepatic cholangiocarcinoma cell (RBE), human breast cancer cell (MCF-7), human pancreatic cancer cell (BxPC3), human bladder cancer cell (T24), human bladder cancer cell (umuc3) show strong inhibitory activity. Among them, the antitumor activity of compound D-18 is most outstanding, and shows strong inhibition to the 8 tumor cell lines measured, IC 50 The range is 0.2585-10.69 μM, significantly better than the control drug irinotecan, and comparable to topotecan activity. Therefore, indole camptothecin derivatives are expected to be developed into a new antitumor drug.

The utility model discloses a kind of for bladder washing set, belong to medical instrument technical field. Including with urethra physiological bending compliance washing pipe, washing pipe is opened in and goes liquid passage, washing pipe head is opened with the side hole that goes liquid passage is communicated, washing pipe tail is provided with liquid supply component and washing component. The set is through setting with urethra physiological bending compliance washing pipe, can easily pipe body is in-depth into human bladder, by controlling three-way valve, first physiological saline is extruded into washing balloon, then make washing balloon and washing pipe communicate, extrude washing balloon, complete the washing of bladder, simultaneously, it can also be the tissue fragment in bladder, blood clot is sucked to washing balloon in side hole, it is extracted from human, convenient operation, it can be completed in bedside, greatly reduce the risk of bladder cancer electrocision patient secondary operation, strong practicality.

The invention provides a biomarker for diagnosing bladder cancer and application of the biomarker, and by analyzing single-cell transcriptome data of normal bladder epithelial cells and bladder cancer cells, ZDHHC20 is found to be continuously increased in the process of transforming from the bladder epithelial cells to vicious cells, and is remarkably and highly expressed in human bladder cancer tissues. Functional studies show that overexpression of ZDHHC20 can significantly activate PI3K / AKT, Wnt / beta-catenin, cell cycle and other cancer-promoting signal channels, so that normal bladder epithelial cells obtain malignant growth ability independent of adherence. The results show that ZDHHC20 is an important molecule for driving the vicious transformation of bladder epithelial cells. The invention discloses a key effect of the ZDHHC20 in bladder cancer generation, and shows that the ZDHHC20 can be used as a bladder cancer diagnosis and treatment target.

The invention relates to the technical field of bladder irrigation, and discloses a bladder irrigation device with a constant temperature and speed control alarm function, the bladder irrigation device comprises an infusion support and a catheter body inserted into the bladder of a human body and communicated with a drainage bag, a heat preservation device is installed on the surface of the infusion support, and the heat preservation device comprises a supporting seat and a temperature control device; the supporting seat is fixed to the surface of an infusion support telescopic rod, and the top of the supporting seat is rotationally connected with a movable disc; the constant-temperature parts are fixed to the two sides of the movable disc, and the sizes of the constant-temperature parts on the two sides are matched with the size of an infusion bottle; the limiting piece II is arranged between the supporting seat and the constant-temperature part and is used for fixing the rotated constant-temperature part; after an infusion bottle is placed in the infusion plate, along with the attachment and fixation of the cover plate and the infusion plate, the infusion bottle can be heated by starting the heating piece, so that the infusion bottle can be kept in a constant-temperature state, and the bladder can be conveniently and better flushed in the follow-up process.