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Completely biodegradable composite scaffold

A composite material and biodegradable technology, which is applied in the field of fully biodegradable composite material scaffolds and their composition structures, can solve the problems of easy drug loss, limited drug loading, and inability to achieve controlled and sustained release, and achieve simple preparation methods Practical, excellent mechanical properties, low cost effect

Inactive Publication Date: 2014-03-12
BEIJING ZHONGKE YIZHONG TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing stent drug loading method is mainly through the surface coating method, the drug loading is limited, the drug is easy to lose, and the controlled release and sustained release cannot be achieved.

Method used

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  • Completely biodegradable composite scaffold
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Embodiment Construction

[0030] The technical solutions of the present invention will be described in further detail below in conjunction with specific embodiments, and the following specific embodiments are used to illustrate the present invention, but are not intended to limit the scope of the present invention.

[0031] Firstly, the degradable polymer material for preparing the degradable scaffold is synthesized. It is carried out by condensation polymerization, radical polymerization, ionic polymerization, etc. known to those skilled in the art. Specific polymerization methods include bulk polymerization, solution polymerization, suspension polymerization, emulsion polymerization, microemulsion polymerization, inverse emulsion polymerization, dispersion polymerization and the like. Among them, the emulsion polymerization method has many advantages. It can obtain a high polymer molecular weight while increasing the polymerization rate (the factors that increase the rate in other polymerization meth...

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Abstract

The invention relates to a completely biodegradable composite scaffold. The completely biodegradable composite scaffold is characterized by comprising a skeleton structure composed of a medical degradable high-polymer material, a degradable high-polymer functional layer adhered on the surface of the skeleton structure and a drug-loaded layer. The biodegradable composite scaffold provided by the invention has excellent mechanical characteristics, biodegradability and compatibility, realizes active directional targeted treatment of lesion sites by carrying drugs like paclitaxel, sirolimus, actinomycin D and 5-fluorouracil and radioactive elements like 60Co, 125I and 192Ir and is a functional biodegradable scaffold. The degradable drug-loaded multifunctional scaffold is applicable to interventional therapy in vascular and non-vascular fields, especially to interventional therapy of stenosis, obstruction or tumors of non-vascular lumens of the esophagus, the bile duct, the pancreatic duct, the intestinal tract, the urethra, the trachea, the bronchus and the like.

Description

technical field [0001] The invention belongs to the field of medical devices, and relates to a completely biodegradable composite material bracket and its composition structure. Background technique [0002] In recent years, stent intervention has become an effective minimally invasive treatment technique for cardiovascular and cerebrovascular stenosis and obstruction, as well as esophagus, bile duct, pancreatic duct, intestinal tract, urethra, trachea, bronchi and other non-vascular lumens. A fast, effective and relatively safe medical method, especially for tumor patients, can significantly improve their survival period and quality of life. [0003] Stent interventional therapy has been widely used in vascular surgery, thoracic surgery, urology, and digestive surgery. Using X-ray fluoroscopy, CT positioning, B-ultrasound and other medical imaging equipment, through the introduction of special catheters or instruments, interventional doctors have been able to deliver stent...

Claims

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Application Information

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IPC IPC(8): A61L31/04A61L31/06A61L31/02A61L31/10A61L31/14A61L31/16A61L27/18A61L27/16A61L27/26A61L27/12A61L27/02A61L27/34A61L27/58A61L27/54A61L17/10A61L17/12A61L24/04A61L24/06A61L24/08A61L24/10A61L24/02
Inventor 邢长民张伟
Owner BEIJING ZHONGKE YIZHONG TECH
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