32results about How to "Avoid cancer risk" patented technology

The invention belongs to the technical field of molecular biology and relates to application of an exosome derived from human mesenchymal stem cells to preparation of medicines for antagonizing scars or tissue and organ fibrosis. According to the application, the high-purity and high-bioactivity exosome is obtained by subjecting healthy human umbilical cords to primary in-vitro culture, collecting liquid supernatant after amplification, performing low-temperature ultracentrifugation, purifying and the like; the exosome is used individually or added into medicines, health care products and cosmetics according to a proportion to be developed into a product with a bioactivity function, thereby being capable of regulating organism cell signal transduction effectively, inhibiting fibrocyte differentiation and then antagonizing the tissue and organ fibrosis and scar forming. Through experimental verification, the exosome can play a remarkable role in repairing promotion in hypertrophic scar after skin injury, particularly pathological fibrosis proliferation such as scar contracture of the joint parts, hepatic fibrosis and cardiac fibrosis, and is high in safety, little in toxicity and convenient to storage and transport, thereby being wide in application prospect.

The invention relates to the technical field of biology, in particular to an application of exosomes from mesenchymal stem cell in preparation medicine of promoting vascularization or inducing angiogenesis. The exosomes, processed with gradient centrifugation, filtering and ultracentrifugation, is with high purity. The exosomes has the advantages of easy preparation and storage, high safety coefficient, easy absorption, wide medicine route, has targeting ability, and makes the endothelial cells of the blood vessels come together and create new vessels, so that the microcirculation is reconstructed to increase blood flow perfusion. The deficiency of other functions is not caused, and the exosomes has a wide application prospect.

The invention discloses a chitosan quaternary ammonium salt couplant and a preparation method thereof. The chitosan quaternary ammonium salt couplant is prepared from 0.1-0.9wt% of Carbomer 941, 0.5-6wt% of phenoxyethanol, 0.01-1.0wt% of hydrochloric acid, 0.1-0.8wt% of chitosan quaternary ammonium salt, 1.2-10wt% of triethanolamine, 2-20wt% of a humectant and the balance distilled water. The chitosan quaternary ammonium salt couplant has the advantages of good bactericidal effects, good environmental performances, no carcinogenesis on the human body, clarification, transparency, alcohol fragrance, good homogeneity and good fineness.

The invention relates to an absorbable artificial dura mater having anti-infection function, and a preparation method and an application thereof. The anti-infection artificial dura mater is composed of a nano-fiber membrane having a double layer structure and a high-molecular material having a three-dimensional porous structure. The nano-fiber membrane in the double layer structure is composed of a degradable polyester nano-fiber membrane and a chitosan nano-fiber membrane. The high-molecular material in the three-dimensional porous structure is made from a natural high-molecular substance and is located inside and on the surface of the nano-fiber membrane. The absorbable artificial dura mater has good anti-infection function and can effectively prevent post-operation intracranial infection, can bear certain suture force without tearing and edge falling off, is deformable but is free of damage. Meanwhile, the nano microporous structure can effectively prevent tissue adhesion and has excellent hydration property, compliance and adhesivity, so that the artificial dura mater can be directly used in clinical application in an attachment manner, thereby achieving suture-free fixation. The artificial dura mater can be completely degraded and absorbed, thereby avoiding carcinogenic risk of the membrane sheets.

The invention provides a chrome-free tanning method of alligator skin. The chrome-free tanning method comprises the following steps of (1) adding water and sodium chloride to a rotary drum or a paddle vat, adding a pickling alligator skin blank after the sodium chloride is dissolved, rotating the rotary drum or paddling a paddle plate for 5-10 minutes, and regulating the pH value of a mixed solution inside the rotary drum or the paddle vat to 3.4-3.7; (2) adding an organic phosphonium salt tanning agent, an alcamines compound and fatty aldehyde to the rotary drum or the paddle vat, then rotating the rotary drum or paddling the paddle plate for 10-20 minutes, standing for 30-60 minutes, and repeating the operation of rotating the rotary drum or paddling the paddle plate and standing till the alligator skin blank is fully impregnated; (3) regulating the pH value of the mixed solution inside the rotary drum or the paddle vat to 5.8-6.2, then rotating the rotary drum or paddling the paddle plate for 5-10 minutes, standing for 30-60 minutes, and repeating the operation of rotating the rotary drum or paddling the paddle plate and standing for 3-5 times, then standing for 6-12 hours, and then completely discharging the mixed solution; (4) adding the water and an oxidizing agent to the rotary drum or the paddle vat, then rotating the rotary drum or paddling the paddle plate for 5-10 minutes, standing for 30-60 minutes, and repeating the operation of rotating the rotary drum or paddling the paddle plate and standing for 3-5 times.

The invention discloses a method for extracting exosome from amniotic mesenchymal stem cells and application of the exosome. The exosome is obtained through the steps of amnion separation, washing, epithelial cell removal, shearing, digestion, centrifugation, second-layer suspension taking, resuspension, inoculated culture, subsequent extraction preparation and the like. When the exosome is applied to a medicine for promoting angiogenesis and osteogenesis, vascular endothelial cell aggregation and angiogenesis can be achieved, a microcirculation is reconstructed, blood perfusion is increased,lost of other functions is not caused, and the application prospect is promising. According to the method, the cell extraction process is optimized, the amniotic stem cell extraction efficiency is higher, the purity is higher, and on the premise that more cells are obtained, it can be guaranteed that more exosomes are obtained.

The invention belongs to a medical biological material technology field, concretes a chitosan fiber film, wherein the fiber film is prepared from a chitosan spinning solution, which is a mixed solution containing chitosan, hexafluroisopropyl alcohol and acetate. The invention further provides a method for preparing the chitosan fiber film, and applications of the fiber film for preparing endocranium or endorhachis defect repairing material, cerebrospinal fluid leakage plugging material or a tissue adhesion prevention medicament.

The invention belongs to the field of biology, and particularly relates to a skincare stem cell activin and a preparation method and application thereof. The preparation method of the skincare stem cell activin includes the steps of S1, culturing stem cells in vitro; S2, collecting the stem cells, performing cell lysis to obtain cell lysate, subjecting the cell lysate to low-speed centrifuging, removing cell debris, and freezing to preserve supernate to obtain the stem cell activin. Compared with general chemical skincare products, the skincare stem-cell activin has the advantages that under action of the cell signal regulation mechanism and the synergistic effect of various growth factors, nutrition metabolism of epithelial cells can be improved, skin protection can be achieved, skin injury caused by various reasons can be prevented and cured, skin collagenocyte growth can be accelerated, collagen secretion of skin can be accelerated, and further, wrinkle resistance and ageing resistance can be achieved. Therefore, the skincare stem cell activin has good application prospect in fields of medicines, healthcare and beautifying.

The invention relates to tire tread which comprises 1-60 parts of solution polymerized styrene-butadiene rubber, 1-40 parts of natural rubber, 1.5 parts of environment-friendly promoter, 10-100 parts of high-dispersion white carbon black, 1-8 parts of silane coupling agent, 10-50 parts of carbon black and 1-20 parts of petroleum-series aromatic hydrocarbon oil. Preferably, the environment-friendly promoter is a compound of zinc dialkyl dithiophsophate and a carrier. The invention further provides a preparation method of the tire tread. The preparation process is divided into three adding and mixing stages, and the environment-friendly promoter is added at the productive stage. The tire tread and the preparation method have the advantages that combined use of the solution polymerized styrene-butadiene rubber, the natural rubber, the high-dispersion white carbon black, the silane coupling agent and the environment-friendly promoter is considered important for promoting scorching time, improving modulus and wear performance and lowering rolling resistance. By using the environment-friendly promoter, toxic, allergic and carcinogenic risks in the operation process can be avoided.

The invention discloses an intelligent cancer risk prediction method and system. The system comprises a touchable screen interaction interface, an artificial intelligence voice system, an internal memory and a system processor. A user touches a screen 'start' button on the touchable screen interaction interface to start answering questions; the artificial intelligence voice system directly interacts with the user, the artificial intelligence voice system can read each question to be answered by the user, and the user gives an answer meeting the condition of the user according to the heard question; and alternative answers of each question, a possible risk factor corresponding to each cancer and a relative risk degree between each risk factor and the corresponding cancer are preset in the internal memory of a terminal. The system allows the user to perform cancer risk prediction in various scenes, provides a simple and easy cancer risk screening means for the user, and can better prevent the cancer risk of the public.

The invention relates to the technical field of room-temperature-cured silicone rubber, specifically to non-corrosive ketoxime-type room-temperature-cured silicone rubber and a preparation method. Theketoxime-type room-temperature-cured silicone rubber is made by mixing, by weight, 40-60 parts of hydroxyl-terminated polysiloxane, 3-6 parts of methyl isobutylketoxime silane, 1-5 parts of a silicane coupling agent, 5-15 parts of a plasticizer, 0.1-1 part of a catalyst, 10-30 parts of a filling material, and 1-10 parts of pigment. The preparation method comprises mixing hydroxyl-terminated polysiloxane, the plasticizer, the filling material and pigment, performing vacuum stirring, adding methyl isobutylketoxime silane, the silicane coupling agent and the catalyst, and performing vacuum stirring to obtain a material of the room-temperature-cured silicone rubber. Methylisobutylketone produced in a vulcanization process of ketoxime-type room-temperature-cured silicone rubber is non-corrosive to a polyurethane material. The requirement to the ketoxime-type room-temperature-cured silicone rubber is met in automobile and electronic industries. The tensile strength of rubber is high, the bonding property of the rubber material is great, and the preparation method is simple.

The invention discloses an HPV58 type E6 / E7 fusion gene. The fusion gene removes the termination codes of the HPV58 type E6 and E7 genes, and at the same time combines the 50th, 63rd and 106th amino acids on the E6 protein with the 24th amino acid on the E7 protein. , 26 and 92 amino acids are all mutated to glycine. The invention also discloses a therapeutic composite gene vaccine prepared by using the fusion gene, which uses the fusion gene as a target antigen and human interleukin 12 (hIL12) as an antigen adjuvant. The fusion gene and therapeutic compound gene vaccine provided by the present invention have high safety, strong immune effect and ideal antitumor, and provide a better choice for the treatment of cervical cancer and precancerous lesions related to HPV58 infection, especially suitable for HPV58 high Infected Chinese and Asian cervical cancer patients.

The invention discloses a chitosan quaternary ammonium salt couplant and a preparation method thereof. The chitosan quaternary ammonium salt couplant is prepared from 0.1-0.9wt% of Carbomer 941, 0.5-6wt% of phenoxyethanol, 0.01-1.0wt% of hydrochloric acid, 0.1-0.8wt% of chitosan quaternary ammonium salt, 1.2-10wt% of triethanolamine, 2-20wt% of a humectant and the balance distilled water. The chitosan quaternary ammonium salt couplant has the advantages of good bactericidal effects, good environmental performances, no carcinogenesis on the human body, clarification, transparency, alcohol fragrance, good homogeneity and good fineness.

The invention relates to a chemical small molecule composition and a method for chemically inducing in-vitro and in-vivo fibroblasts to be directly reprogrammed (transdifferentiated) into hepatocytesonly by using chemical small molecules (small molecules for short) without introducing any exogenous gene / transcription factor / MicroRNA gene, RNA, protein, polypeptide and other inducible factors. Themicromolecule composition induces fibroblasts to be transdifferentiated into hepatocytes in vitro or chemically induces in-situ fibroblasts to be transdifferentiated into hepatocytes in vivo, fibrosis of fibrotic tissues or organs is reduced or reduced through the in-situ transdifferentiation effect of the hepatocytes in vivo, and the effect of treating fibrotic diseases such as hepatic fibrosis / liver cirrhosis is achieved. The small molecule composition can be added with a drug carrier and an excipient to prepare a drug or a prodrug for treating fibrotic diseases, or added with normal saline, a buffer solution, a cell basal culture medium and the like to prepare a transdifferentiation reagent or a culture medium; the obtained transdifferentiated hepatocytes can provide hepatocyte sourcesfor scientific research, medicine, clinical hepatocyte transplantation and the like.

The invention provides a blood state detection device and a method for acquiring temperature change values. The device comprises a first temperature collection unit, a second temperature collection unit, a first adhesion mechanism, a second adhesion mechanism and a detection part; the first adhesion mechanism adheres the first temperature collection unit to the skin surface where a to-be-detected area is located; the second adhesion mechanism adheres the second temperature collection unit to the skin surface where a specified area is located; the first temperature collection unit collects first temperature information of the to-be-detected area and sends the first temperature information to the detection part; the second temperature collection unit collects second temperature information of the specified area and sends the second temperature information to the detection part; the detection part receives the first temperature information and the second temperature information, calculates the temperature change values corresponding to the to-be-detected area and the specified area respectively according to the first temperature information and the second temperature information and determines the blood state of the to-be detected area according to the temperature change values corresponding to the to-be-detected area and the specified area respectively. According to the technical scheme, the security is high.

The invention discloses application of rumex madaio makino to drugs for treating psoriasis, and particularly relates to the rumex madaio makino alcohol extract 70% ethanol eluted part which achieves the treatment effect through a way of immunoregulation. The invention provides pharmacodynamics study of the rumex madaio makino alcohol extract 70% ethanol eluted part on an imiquimod induced psoriasis mouse model and shows that the drug has an improving effect on the skin symptom caused by psoriasis, and meanwhile, can improve the symptoms of combination of psoriasis and liver and renal functiondamage, and thus the drug which is economical, effective, safe and reliable is provided for treatment of psoriasis.

The invention discloses environment-friendly building active glue which is prepared from polyvinyl alcohol powder and ozone water. The environment-friendly building active glue has the beneficial effects that the environment-friendly building active glue is safe and environment-friendly, free of substances, such as formaldehyde and acrylamide harmful to a human body, strong in bactericidal ability and fewer in bacteria; a carcinogenic risk caused by manpower can be avoided; human health of a worker can be protected; the building glue is fabricated in a manner of mixing the polyvinyl alcohol powder and the ozone water instead of the traditional heat boiling mode. The production technology is simplified; the target of producing the environment-friendly building active glue can be achieved by using simple equipment; the production is not limited by the conditions of time and place; the production efficiency is high; the used environment-friendly building glue is free of volatilizable harmful substances, has a good using effect, and plays a protection role in people living in the building; the environment-friendly effect can be completely achieved; popularization is facilitated.

The invention discloses a composite passivation solution and a preparation method thereof. The composite passivation solution does not contain chromium ions, so that heavy metals are prevented from causing carcinogenic hidden dangers to human bodies and harm to the ecological environment. In an anti-corrosion film formed by passivating the surface of a metal product through the composite passivation solution, the laminar graphene oxide can enhance the physical shielding performance of the anti-corrosion film on a corrosion medium; by adding the cobalt salt, the current inhibition capability of the anti-corrosion film can be enhanced; and ethylene diamine tetraacetic acid (EDTA for short) can be complexed and coordinated with metal ions to form a complex compound with an annular structure on one hand, and can also form a non-covalent bond with hydroxyl on the surface of graphene oxide on the other hand, so that the binding force between the anti-corrosion film and a metal substrate is improved. The preparation method of the composite passivation solution is simple in operation steps, and the feasibility of preparation and implementation of the composite passivation solution is ensured.

The invention discloses an antibacterial and alga-control film for barreled drinking water. The antibacterial and alga-control film is arranged in the body of a barrel; an antibacterial and alga-control film neck is arranged at the position of the outlet of the antibacterial and alga-control film for barreled drinking water; the mouth rim of the antibacterial and alga-control film neck extends out of the neck opening of the barrel; after the mouth rim of the antibacterial and alga-control film neck extends out from the neck opening of the barrel and turned down, the barrel neck opening is covered; and the barrel neck opening and the cover are matched and connected. The film has the advantages that: the effective use of the film in the production of barreled water reduces the cost of products, solves an ozone residue problem and avoids the potential cancer risks aroused to human body by superstandard bromated; meanwhile, lots of high-quality water resources are saved, serious environment pollution caused by immersing, sterilizing, washing and the like is reduced, and thus, the film is in accordance with the environment-protection, energy-conservation and emission-reduction policies of China.

The invention discloses an anti-aging repair product for a female reproductive system and a preparation method of the anti-aging repair product. Main components of the anti-aging repair product comprise coumestrol, viatmin E, rhizoma curcumae, sodium hyaluronate and collagen. The anti-aging repair product disclosed by the invention can improve the estrogen level in a body when estrogen is insufficiently secreted and also can promote the expression of an estrogen receptor on reproductive system tissue cells of the reproductive system; the estrogen is combined with the estrogen receptor on vaginal tissues to improve lycogenesis, so that lactobacillus favorably degrades glycogen to produce lactic acid for keeping the vaginal acid environment; pathogenic bacteria are resisted, and senile vaginitis is prevented; meanwhile, vaginal lubrication degree and wettability can be improved, and vaginal dryness and atrophy are avoided; besides, degenerative change of the female reproductive system isprevented or improved in a safe effective mode.

The invention belongs to the field of metal machining fluids, and discloses a heavy-load metal machining total synthesis cutting fluid as well as a preparation method and an application thereof. The total synthesis cutting fluid comprises the following components in percentage by weight: 20%-30% of mixed alcohol amine, 6%-9% of anti-rust agents, 4%-6% of special amine, 6%-10% of lubricating agents, 15%-25% of extreme pressure agents, 6%-10% of cosolvents, 1%-2% of water-softening agents, 1%-3% of corrosion inhibitors and the balance of water. The total synthesis cutting fluid disclosed by the invention has excellent lubricating extreme pressure property, can meet the requirement for heavy-load machining, namely reaming, drilling, tapping, threading, broaching, thread machining and the like, of difficult-to-machine materials, namely high-temperature alloy steel, a titanium alloy and the like; a product is green and environment-friendly without containing boron, sodium nitrite, secondary amine, chlorine, phenol, formaldehyde, heavy metals and the like; in addition, the total synthesis cutting fluid disclosed by the invention has excellent anti-rust property, biological stability and machining property, and can enhance the surface quality of a machined part, prolong the service life of a cutter and reduce the rejection rate, thus improving the production efficiency.

The invention provides a pharmaceutical composition for treating premature ovarian failure as well as application and a preparation method of the pharmaceutical composition. According to the pharmaceutical composition for treating premature ovarian failure, the effects of tonifying qi and strengthening superficies, draining toxin and pus, healing sore and promoting tissue regeneration, engendering liquid and nourishing blood, inducing diuresis to alleviate edema and the like of astragalus membranaceus serving as a Chinese herbal medicine are fully utilized; one or a combination of more of the astragaloside extract, the astragaloside I, the astragaloside II, the astragaloside III and the astragaloside IV is used as a component of the pharmaceutical composition, so that the premature ovarian failure symptom caused by ovarian injury can be effectively relieved and treated; toxic and side effects and carcinogenic risks existing in an existing treatment method are avoided, and the treatment cost is greatly reduced.

The invention relates to the technical field of room temperature curing silicone rubber, in particular to a non-corrosive ketoxime type room temperature curing silicone rubber and a preparation method. The formula of ketoxime type room temperature curing silicone rubber consists of 40-60 parts by weight of hydroxyl-terminated polysiloxane, 3-6 parts of methyl isobutyl ketoximosilane, 1-5 parts of silane coupling agent, plasticizer 5 to 15 parts, 0.1 to 1 part of catalyst, 10 to 30 parts of filler, and 1 to 10 parts of pigment are obtained by mixing hydroxyl-terminated polysiloxane, plasticizer, filler and pigment, and then adding methyliso butanone oximino silane, a silane coupling agent, a catalyst, and vacuum stirring to obtain a room-temperature-cured silicone rubber compound. The methyl isobutyl ketone oxime produced during the vulcanization process of the ketoxime type room temperature curing silicone rubber is non-corrosive to polyurethane materials, and meets the needs of the automobile and electronics industries for ketoxime type room temperature curing silicone rubber. The colloid has high tensile strength, In addition, the bonding performance of the rubber material is strong, and the preparation method is simple.

The invention belongs to a medical biological material technology field, concretes a chitosan fiber film, wherein the fiber film is prepared from a chitosan spinning solution, which is a mixed solution containing chitosan, hexafluroisopropyl alcohol and acetate. The invention further provides a method for preparing the chitosan fiber film, and applications of the fiber film for preparing endocranium or endorhachis defect repairing material, cerebrospinal fluid leakage plugging material or a tissue adhesion prevention medicament.

The invention belongs to the field of regenerative medicine materials, and in particular relates to an antibacterial cation-modified absorbable pachymeninx repair material and a preparation method and application thereof. The antibacterial cation-modified absorbable pachymeninx repair material is of a double-layer structure consisting of a degradable polyester nanofiber membrane modified by epsilon-polylysine and a three-dimensional porous high-molecular material. The absorbable pachymeninx repair material provided by the invention has excellent antibacterial characteristic, can effectively prevent postoperative intracranial infection, and can be directly attached and sewed for use; product compositions and a preparation process are simple, and industrial production are easily realized. The antibacterial cation-modified absorbable pachymeninx repair material of the invention is a novel medical biological material which is novel in structure and excellent in performance, and presents a good application prospect in the field of pachymeninx defect repair.

The invention relates to a method for preparing fried snack food at low temperature. The method comprises the following steps: cleaning the food raw material; cutting the cleaned food raw material into slices or strips; steaming and cooking the sliced or stripped food raw material to obtain the semi-finished product with 80 percent cooked; cooling the semi-finished product to the room temperature, and freezing the semi-finished product at the temperature of minus 17 DEG C to minus 20 DEG C for 24 to 48 hours to obtain the frozen semi-finished product; frying the frozen semi-finished product, which is not unfrozen, for 25 to 45 minutes at low temperature of between 78 and 98 DEG C and under the vacuum condition to obtain deoiled food; and packaging the deoiled food to obtain the finished product, namely, the fried snack food. By the method for preparing fried snack food at low temperature, the carcinogenic defect in the traditional process is eliminated, the application range is wide, and the process flow processing efficiency is high.

The invention provides a chrome-free tanning method of alligator skin. The chrome-free tanning method comprises the following steps of (1) adding water and sodium chloride to a rotary drum or a paddle vat, adding a pickling alligator skin blank after the sodium chloride is dissolved, rotating the rotary drum or paddling a paddle plate for 5-10 minutes, and regulating the pH value of a mixed solution inside the rotary drum or the paddle vat to 3.4-3.7; (2) adding an organic phosphonium salt tanning agent, an alcamines compound and fatty aldehyde to the rotary drum or the paddle vat, then rotating the rotary drum or paddling the paddle plate for 10-20 minutes, standing for 30-60 minutes, and repeating the operation of rotating the rotary drum or paddling the paddle plate and standing till the alligator skin blank is fully impregnated; (3) regulating the pH value of the mixed solution inside the rotary drum or the paddle vat to 5.8-6.2, then rotating the rotary drum or paddling the paddle plate for 5-10 minutes, standing for 30-60 minutes, and repeating the operation of rotating the rotary drum or paddling the paddle plate and standing for 3-5 times, then standing for 6-12 hours, and then completely discharging the mixed solution; (4) adding the water and an oxidizing agent to the rotary drum or the paddle vat, then rotating the rotary drum or paddling the paddle plate for 5-10 minutes, standing for 30-60 minutes, and repeating the operation of rotating the rotary drum or paddling the paddle plate and standing for 3-5 times.

The invention relates to eco-friendly building active glue. The eco-friendly building active glue is prepared from polyvinyl alcohol powder and ozone water. The eco-friendly building active glue is safe and environmentally friendly, does not contain formaldehyde and acrylamide harmful for the human body, has a strong sterilization capability, has less bacteria, prevents a worker-caused carcinogenesis risk and protects worker health. The polyvinyl alcohol-ozone water mixture replaces the building glue obtained through the traditional heating boiling method so that a production technology is simplified, eco-friendly building active glue production is realized through simple equipment, production is not limited through time and place and production efficiency is high. The used eco-friendly building active glue does not produce any volatile harmful substances, completely realizes environmental protection effects, can protect people living in a building, has good use effects and is conducive to promotion.