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32results about How to "Avoid cancer risk" patented technology

Application of exosome derived from human mesenchymal stem cells to resistance to tissue fibrosis and scar forming

The invention belongs to the technical field of molecular biology and relates to application of an exosome derived from human mesenchymal stem cells to preparation of medicines for antagonizing scars or tissue and organ fibrosis. According to the application, the high-purity and high-bioactivity exosome is obtained by subjecting healthy human umbilical cords to primary in-vitro culture, collecting liquid supernatant after amplification, performing low-temperature ultracentrifugation, purifying and the like; the exosome is used individually or added into medicines, health care products and cosmetics according to a proportion to be developed into a product with a bioactivity function, thereby being capable of regulating organism cell signal transduction effectively, inhibiting fibrocyte differentiation and then antagonizing the tissue and organ fibrosis and scar forming. Through experimental verification, the exosome can play a remarkable role in repairing promotion in hypertrophic scar after skin injury, particularly pathological fibrosis proliferation such as scar contracture of the joint parts, hepatic fibrosis and cardiac fibrosis, and is high in safety, little in toxicity and convenient to storage and transport, thereby being wide in application prospect.
Owner:SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY

Absorbable artificial dura mater having anti-infection function, preparation method and application thereof

InactiveCN106943634AStrong resistance to infectionAvoid infectionProsthesisPolyesterFiber
The invention relates to an absorbable artificial dura mater having anti-infection function, and a preparation method and an application thereof. The anti-infection artificial dura mater is composed of a nano-fiber membrane having a double layer structure and a high-molecular material having a three-dimensional porous structure. The nano-fiber membrane in the double layer structure is composed of a degradable polyester nano-fiber membrane and a chitosan nano-fiber membrane. The high-molecular material in the three-dimensional porous structure is made from a natural high-molecular substance and is located inside and on the surface of the nano-fiber membrane. The absorbable artificial dura mater has good anti-infection function and can effectively prevent post-operation intracranial infection, can bear certain suture force without tearing and edge falling off, is deformable but is free of damage. Meanwhile, the nano microporous structure can effectively prevent tissue adhesion and has excellent hydration property, compliance and adhesivity, so that the artificial dura mater can be directly used in clinical application in an attachment manner, thereby achieving suture-free fixation. The artificial dura mater can be completely degraded and absorbed, thereby avoiding carcinogenic risk of the membrane sheets.
Owner:YANTAI ZHENGHAI BIO TECH

Chrome-free tanning method of alligator skin

The invention provides a chrome-free tanning method of alligator skin. The chrome-free tanning method comprises the following steps of (1) adding water and sodium chloride to a rotary drum or a paddle vat, adding a pickling alligator skin blank after the sodium chloride is dissolved, rotating the rotary drum or paddling a paddle plate for 5-10 minutes, and regulating the pH value of a mixed solution inside the rotary drum or the paddle vat to 3.4-3.7; (2) adding an organic phosphonium salt tanning agent, an alcamines compound and fatty aldehyde to the rotary drum or the paddle vat, then rotating the rotary drum or paddling the paddle plate for 10-20 minutes, standing for 30-60 minutes, and repeating the operation of rotating the rotary drum or paddling the paddle plate and standing till the alligator skin blank is fully impregnated; (3) regulating the pH value of the mixed solution inside the rotary drum or the paddle vat to 5.8-6.2, then rotating the rotary drum or paddling the paddle plate for 5-10 minutes, standing for 30-60 minutes, and repeating the operation of rotating the rotary drum or paddling the paddle plate and standing for 3-5 times, then standing for 6-12 hours, and then completely discharging the mixed solution; (4) adding the water and an oxidizing agent to the rotary drum or the paddle vat, then rotating the rotary drum or paddling the paddle plate for 5-10 minutes, standing for 30-60 minutes, and repeating the operation of rotating the rotary drum or paddling the paddle plate and standing for 3-5 times.
Owner:广西盟展鳄鱼科技开发有限公司

Non-corrosive ketoxime-type room-temperature-cured silicone rubber and preparation method

The invention relates to the technical field of room-temperature-cured silicone rubber, specifically to non-corrosive ketoxime-type room-temperature-cured silicone rubber and a preparation method. Theketoxime-type room-temperature-cured silicone rubber is made by mixing, by weight, 40-60 parts of hydroxyl-terminated polysiloxane, 3-6 parts of methyl isobutylketoxime silane, 1-5 parts of a silicane coupling agent, 5-15 parts of a plasticizer, 0.1-1 part of a catalyst, 10-30 parts of a filling material, and 1-10 parts of pigment. The preparation method comprises mixing hydroxyl-terminated polysiloxane, the plasticizer, the filling material and pigment, performing vacuum stirring, adding methyl isobutylketoxime silane, the silicane coupling agent and the catalyst, and performing vacuum stirring to obtain a material of the room-temperature-cured silicone rubber. Methylisobutylketone produced in a vulcanization process of ketoxime-type room-temperature-cured silicone rubber is non-corrosive to a polyurethane material. The requirement to the ketoxime-type room-temperature-cured silicone rubber is met in automobile and electronic industries. The tensile strength of rubber is high, the bonding property of the rubber material is great, and the preparation method is simple.
Owner:ZHEJIANG QUZHOU GUIBAO CHEM

Amplification method of pancreatic cells and differentiation method and application of pancreatic precursor-like cells

The invention provides an amplification method of pancreatic cells. The amplification method comprises the following steps: sequentially carrying out digestion treatment, resuspension treatment, discontinuous density gradient centrifugation treatment and amplification treatment on pancreatic tissues. According to the amplification method disclosed by the invention, pancreatic ducts of mammals are used as sources of pancreatic precursor-like cells, and islet cells and acinar cells in obtained cell clusters are removed after the discontinuous density gradient centrifugal treatment, thus being good for improving the yield of pancreatic precursor-like cells, and avoiding ethical limitations and possible carcinogenic risk caused by the use of embryonic stem cells; and an amplification culture medium used in the invention comprises a reprogramming substance consisting of a plurality of small molecule compounds, so as to avoid the risks of nonspecificity, off-target deletion, etc., which are easily caused by changing gene sequences by using a gene editing method. The invention also provides a differentiation method and application of the pancreatic precursor-like cells obtained by the amplification method.
Owner:SHANGHAI CELLIVER BIOTECHNOLOGY CO LTD +1

Chemical small molecule composition and method for directly reprogramming in-vitro and in-vivo chemically induced fibroblasts into hepatocytes

The invention relates to a chemical small molecule composition and a method for chemically inducing in-vitro and in-vivo fibroblasts to be directly reprogrammed (transdifferentiated) into hepatocytesonly by using chemical small molecules (small molecules for short) without introducing any exogenous gene / transcription factor / MicroRNA gene, RNA, protein, polypeptide and other inducible factors. Themicromolecule composition induces fibroblasts to be transdifferentiated into hepatocytes in vitro or chemically induces in-situ fibroblasts to be transdifferentiated into hepatocytes in vivo, fibrosis of fibrotic tissues or organs is reduced or reduced through the in-situ transdifferentiation effect of the hepatocytes in vivo, and the effect of treating fibrotic diseases such as hepatic fibrosis / liver cirrhosis is achieved. The small molecule composition can be added with a drug carrier and an excipient to prepare a drug or a prodrug for treating fibrotic diseases, or added with normal saline, a buffer solution, a cell basal culture medium and the like to prepare a transdifferentiation reagent or a culture medium; the obtained transdifferentiated hepatocytes can provide hepatocyte sourcesfor scientific research, medicine, clinical hepatocyte transplantation and the like.
Owner:TRANSCEND CYTOTHERAPY CO LTD

Blood state detection device and method for acquiring temperature change values

ActiveCN106166061AReduce the temperatureThe temperature change value is reducedSensorsBlood flow measurementEngineeringSkin surfaces
The invention provides a blood state detection device and a method for acquiring temperature change values. The device comprises a first temperature collection unit, a second temperature collection unit, a first adhesion mechanism, a second adhesion mechanism and a detection part; the first adhesion mechanism adheres the first temperature collection unit to the skin surface where a to-be-detected area is located; the second adhesion mechanism adheres the second temperature collection unit to the skin surface where a specified area is located; the first temperature collection unit collects first temperature information of the to-be-detected area and sends the first temperature information to the detection part; the second temperature collection unit collects second temperature information of the specified area and sends the second temperature information to the detection part; the detection part receives the first temperature information and the second temperature information, calculates the temperature change values corresponding to the to-be-detected area and the specified area respectively according to the first temperature information and the second temperature information and determines the blood state of the to-be detected area according to the temperature change values corresponding to the to-be-detected area and the specified area respectively. According to the technical scheme, the security is high.
Owner:苏州涵轩信息科技有限公司

A fully synthetic cutting fluid for heavy-duty metal processing and its preparation method and application

The invention belongs to the field of metal machining fluids, and discloses a heavy-load metal machining total synthesis cutting fluid as well as a preparation method and an application thereof. The total synthesis cutting fluid comprises the following components in percentage by weight: 20%-30% of mixed alcohol amine, 6%-9% of anti-rust agents, 4%-6% of special amine, 6%-10% of lubricating agents, 15%-25% of extreme pressure agents, 6%-10% of cosolvents, 1%-2% of water-softening agents, 1%-3% of corrosion inhibitors and the balance of water. The total synthesis cutting fluid disclosed by the invention has excellent lubricating extreme pressure property, can meet the requirement for heavy-load machining, namely reaming, drilling, tapping, threading, broaching, thread machining and the like, of difficult-to-machine materials, namely high-temperature alloy steel, a titanium alloy and the like; a product is green and environment-friendly without containing boron, sodium nitrite, secondary amine, chlorine, phenol, formaldehyde, heavy metals and the like; in addition, the total synthesis cutting fluid disclosed by the invention has excellent anti-rust property, biological stability and machining property, and can enhance the surface quality of a machined part, prolong the service life of a cutter and reduce the rejection rate, thus improving the production efficiency.
Owner:广州国机润滑科技有限公司

Chrome-free tanning method of alligator skin

The invention provides a chrome-free tanning method of alligator skin. The chrome-free tanning method comprises the following steps of (1) adding water and sodium chloride to a rotary drum or a paddle vat, adding a pickling alligator skin blank after the sodium chloride is dissolved, rotating the rotary drum or paddling a paddle plate for 5-10 minutes, and regulating the pH value of a mixed solution inside the rotary drum or the paddle vat to 3.4-3.7; (2) adding an organic phosphonium salt tanning agent, an alcamines compound and fatty aldehyde to the rotary drum or the paddle vat, then rotating the rotary drum or paddling the paddle plate for 10-20 minutes, standing for 30-60 minutes, and repeating the operation of rotating the rotary drum or paddling the paddle plate and standing till the alligator skin blank is fully impregnated; (3) regulating the pH value of the mixed solution inside the rotary drum or the paddle vat to 5.8-6.2, then rotating the rotary drum or paddling the paddle plate for 5-10 minutes, standing for 30-60 minutes, and repeating the operation of rotating the rotary drum or paddling the paddle plate and standing for 3-5 times, then standing for 6-12 hours, and then completely discharging the mixed solution; (4) adding the water and an oxidizing agent to the rotary drum or the paddle vat, then rotating the rotary drum or paddling the paddle plate for 5-10 minutes, standing for 30-60 minutes, and repeating the operation of rotating the rotary drum or paddling the paddle plate and standing for 3-5 times.
Owner:广西盟展鳄鱼科技开发有限公司
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