The invention belongs to the field of metal machining fluids, and discloses a heavy-load metal machining total synthesis cutting fluid as well as a preparation method and an application thereof. The total synthesis cutting fluid comprises the following components in percentage by weight: 20%-30% of mixed alcohol amine, 6%-9% of anti-rust agents, 4%-6% of special amine, 6%-10% of lubricating agents, 15%-25% of extreme pressure agents, 6%-10% of cosolvents, 1%-2% of water-softening agents, 1%-3% of corrosion inhibitors and the balance of water. The total synthesis cutting fluid disclosed by the invention has excellent lubricating extreme pressure property, can meet the requirement for heavy-load machining, namely reaming, drilling, tapping, threading, broaching, thread machining and the like, of difficult-to-machine materials, namely high-temperature alloy steel, a titanium alloy and the like; a product is green and environment-friendly without containing boron, sodium nitrite, secondary amine, chlorine, phenol, formaldehyde, heavy metals and the like; in addition, the total synthesis cutting fluid disclosed by the invention has excellent anti-rust property, biological stability and machining property, and can enhance the surface quality of a machined part, prolong the service life of a cutter and reduce the rejection rate, thus improving the production efficiency.