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A kind of chitosan quaternary ammonium salt coupling agent and preparation method thereof

A chitosan quaternary ammonium salt and couplant technology, applied in echo/ultrasonic imaging agents and other directions, can solve the problems of poor sterilization effect of sterilization and sterilization ultrasonic couplant, affect gel viscosity, and many bubbles, and improve penetration and Test results, improved compliance, fine gel effect

Active Publication Date: 2017-02-08
WEIFANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The disinfection and sterilization ultrasonic coupling agent made by this patented formula has poor bactericidal effect, and the DPP-300 used as a fungicide has certain carcinogenicity and is harmful to the human body. The sodium hydroxide used in this formula is used as a pH regulator. Sodium can affect the viscosity of the gel, which is not conducive to the formation of the gel. The fineness of the prepared coupling agent is not good enough, the transparency is poor, and there are many bubbles

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] A kind of chitosan quaternary ammonium salt coupling agent, comprises the raw material of following percentage by weight:

[0037] Carbomer 941 0.1%

[0038] Phenoxyethanol 0.5%

[0039] Hydrochloric acid 0.01%

[0040] Hydroxypropyltrimethylammonium Chloride Chitosan (HACC) 0.1%

[0041] Triethanolamine 1.2%

[0042] Propylene Glycol 1%

[0043] Glycerol 1%

[0044] Distilled water to make up the balance.

[0045] Among them, the molecular weight of hydroxypropyltrimethylammonium chitosan (HACC) is 60kDa, the degree of deacetylation is 90%, and the degree of substitution is 30%.

[0046] Prepare chitosan quaternary ammonium salt coupling agent according to the raw material of above-mentioned weight percentage content, concrete steps are as follows:

[0047] (1) Weigh the raw materials according to the above weight percentage, accurately weigh Carbomer 941, and evenly sprinkle it in the first reaction kettle filled with distilled water, where the amount of distil...

Embodiment 2

[0054] A kind of chitosan quaternary ammonium salt coupling agent, comprises the raw material of following percentage by weight:

[0055] Carbomer 941 0.9%

[0056] Phenoxyethanol 6 %

[0057] Hydrochloric acid 1.0%

[0058] Hydroxypropyltrimethylammonium Chloride Chitosan (HACC) 0.2%

[0059] Triethanolamine 10%

[0060] Propylene Glycol 10%

[0061] Glycerol 10%

[0062] Distilled water to make up the balance.

[0063] Among them, hydroxypropyltrimethylammonium chloride chitosan (HACC) has a molecular weight of 120kDa, a degree of deacetylation of 90%, and a degree of substitution of 20%.

[0064] Prepare chitosan quaternary ammonium salt coupling agent according to the raw material of above-mentioned weight percentage content, concrete steps are as follows:

[0065] (1) Weigh the raw materials according to the above weight percentage, accurately weigh Carbomer 941, and evenly sprinkle it in the first reaction kettle filled with distilled water, where the amount of dist...

Embodiment 3

[0072] A kind of chitosan quaternary ammonium salt coupling agent, comprises the raw material of following percentage by weight:

[0073] Carbomer 941 0.4%

[0074] Phenoxyethanol 1.5%

[0075] Hydrochloric acid 0.15%

[0076] Carboxymethyl chitosan quaternary ammonium salt 0.5%

[0077] Triethanolamine 1.2%

[0078] Propylene Glycol 6%

[0079] Glycerol 6%

[0080] Sodium Lauryl Sulfate 0.1%

[0081] Distilled water to make up the balance.

[0082] Among them, the molecular weight of carboxymethyl chitosan quaternary ammonium salt is 120kDa, the degree of deacetylation is 80%, and the degree of substitution is 60%;

[0083] Prepare chitosan quaternary ammonium salt coupling agent according to the raw material of above-mentioned weight percentage content, concrete steps are as follows:

[0084] (1) Weigh the raw materials according to the above weight percentage, accurately weigh Carbomer 941, and evenly sprinkle it in the first reaction kettle filled with distilled wa...

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Abstract

The invention discloses a chitosan quaternary ammonium salt couplant and a preparation method thereof. The chitosan quaternary ammonium salt couplant is prepared from 0.1-0.9wt% of Carbomer 941, 0.5-6wt% of phenoxyethanol, 0.01-1.0wt% of hydrochloric acid, 0.1-0.8wt% of chitosan quaternary ammonium salt, 1.2-10wt% of triethanolamine, 2-20wt% of a humectant and the balance distilled water. The chitosan quaternary ammonium salt couplant has the advantages of good bactericidal effects, good environmental performances, no carcinogenesis on the human body, clarification, transparency, alcohol fragrance, good homogeneity and good fineness.

Description

technical field [0001] The invention relates to the field of medical medicaments, in particular to a medical coupling agent, in particular to a chitosan quaternary ammonium salt coupling agent and a preparation method thereof. Background technique [0002] As we all know, medical couplant is a kind of drug applied on the skin during ultrasonic examination. First, the ultrasonic couplant can fill the tiny gaps between the contact surfaces, so as to prevent the tiny amount of air in the gaps from affecting the penetration and detection results of ultrasound; Secondly, through the transitional effect of the coupling agent, the acoustic impedance difference between the probe and the skin is reduced, thereby reducing the reflection loss of ultrasonic energy at this interface; Reduced so that the probe can slide and explore flexibly. [0003] Most of the medical coupling agents used in clinical B-ultrasound are polymer water-soluble gel preparations, and their chemical components...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/22
Inventor 张维芬郑增娟冯占芹赵庆生
Owner WEIFANG MEDICAL UNIV
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