Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

An antibacterial cation-modified absorbable dura mater repair material and its preparation method and application

A repair material and a cationic technology, applied in the field of antibacterial cationic modified absorbable artificial dura mater and its preparation, can solve the problem that long-term bacteriostasis cannot be achieved, and no polycaprolactone electrospun fiber membrane scaffold material is involved in bacteriostasis characteristics and other issues, to achieve good application prospects, easy control of product quality, and superior performance.

Active Publication Date: 2019-08-20
YANTAI ZHENGHAI BIO TECH
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The polylysine in this patent is added to the inside of the dressing fiber by directly mixing it into the polymer spinning solution. The disadvantage is that the polylysine component is easily freed from the dressing when it comes into contact with the wound surface. Unable to achieve the purpose of long-term antibacterial
This method focuses on introducing carboxyl groups into polycaprolactone molecular chains and activating them, then grafting polylysine and other natural polymers to improve the surface wettability of polycaprolactone fibers. The content of the patent does not involve the polycaprolactone Bacteriostatic Properties of Ester Electrospun Fibrous Membrane Scaffold Materials

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • An antibacterial cation-modified absorbable dura mater repair material and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Dissolve polylactic acid-caprolactone copolymer (PLCL) with a weight average molecular weight of 300,000 in hexafluoroisopropanol at a concentration of 0.08 g / ml, and form a uniform and stable solution after stirring at room temperature. The solution is then put into a syringe, and the needle of the syringe is connected to a high-voltage power supply. The solution supply flow rate was controlled at 1 ml / hour, the applied voltage was 15 kV, the distance between the high-voltage end and the ground end was 15 cm, and a rotating drum with a diameter of 8 cm was used as a collection device at a speed of 100 rpm. After spinning the PLCL solution, a nanofiber film with a thickness of about 0.2 mm can be collected.

[0054] Place the PLCL nanofiber membrane in a low-temperature plasma reaction chamber, close the reaction chamber and evacuate to 5Pa, then pass in helium gas, and adjust the working pressure to 20Pa. After the airflow is stable, turn on the radio frequency power ...

Embodiment 2

[0058] Dissolve poly-L-lactic acid (PLLA) with a weight average molecular weight of 300,000 in chloroform at a concentration of 0.1 g / ml, and form a uniform and stable solution after stirring at room temperature. The solution is then put into a syringe, and the needle of the syringe is connected to a high-voltage power supply. The solution supply flow rate was controlled at 1.5 ml / hour, the applied voltage was 17.5 kV, the distance between the high-voltage end and the ground end was 12.5 cm, and a rotating drum with a diameter of 8 cm was used as a collection device at a speed of 100 rpm. After spinning the PLLA solution, a nanofiber film with a thickness of about 0.25 mm can be collected.

[0059] At 4°C, the PLLA nanofiber membrane was soaked in a 0.1M sodium hydroxide solution for 15 minutes, and then the fiber membrane was taken out and washed with a large amount of deionized water. At 4 °C, the carboxylated PLLA nanofiber membrane was soaked in a mixed solution containin...

Embodiment 3

[0062] Polylactic acid-glycolic acid copolymer (PLGA) with a weight average molecular weight of 250,000 was dissolved in acetone at a concentration of 0.2 g / ml, and a uniform and stable solution was formed after stirring at room temperature. The solution is then put into a syringe, and the needle of the syringe is connected to a high-voltage power supply. The solution supply flow rate was controlled at 2 ml / hour, the applied voltage was 20 kV, the distance between the high voltage end and the ground end was 20 cm, and a rotating drum with a diameter of 8 cm was used as the collection device at a speed of 100 rpm. After spinning the PLGA solution, a nanofiber film with a thickness of about 0.15 mm can be collected.

[0063] Soak the PLGA nanofiber membrane in a hydrogen peroxide solution with a volume fraction of 10%, and then place it under a UV lamp with a wavelength of 350nm and a power of 40W at a distance of 10cm. After reacting for 30 minutes, take it out and wash it with...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
thicknessaaaaaaaaaa
diameteraaaaaaaaaa
sizeaaaaaaaaaa
Login to View More

Abstract

The invention belongs to the field of regenerative medicine materials, and in particular relates to an antibacterial cation-modified absorbable pachymeninx repair material and a preparation method and application thereof. The antibacterial cation-modified absorbable pachymeninx repair material is of a double-layer structure consisting of a degradable polyester nanofiber membrane modified by epsilon-polylysine and a three-dimensional porous high-molecular material. The absorbable pachymeninx repair material provided by the invention has excellent antibacterial characteristic, can effectively prevent postoperative intracranial infection, and can be directly attached and sewed for use; product compositions and a preparation process are simple, and industrial production are easily realized. The antibacterial cation-modified absorbable pachymeninx repair material of the invention is a novel medical biological material which is novel in structure and excellent in performance, and presents a good application prospect in the field of pachymeninx defect repair.

Description

technical field [0001] The invention belongs to the field of regenerative medical materials, and in particular relates to an antibacterial cationic modified absorbable artificial dura mater and its preparation method and application. Background technique [0002] The dura mater is a layer of connective tissue that lines the inside of the skull and the outside of the brain and acts as a natural barrier to protect brain tissue. Open skull injury, tumor metastasis, and other brain diseases can cause dural defects, which in turn lead to cerebrospinal fluid leakage. At the same time, intracranial infection caused by bacterial meningitis is still a common serious complication after craniocerebral surgery. Reported in the literature, the incidence of postoperative intracranial infection is still as high as 0.2% to 5%. Once an infection occurs after the operation, it will not only greatly increase the medical expenses of the patient, but also lead to the failure of the operation a...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/58A61L27/56A61L27/18A61L27/20A61L27/54A61L27/40D01F6/62D06M15/59D06M101/32
Inventor 窦源东任志伟孙先昌尹晓彤陈振华
Owner YANTAI ZHENGHAI BIO TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com