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Magnesium-base metal anti-infection chain bead device

A magnesium-based metal, anti-infection technology, applied in the field of medical devices, to achieve the effect of promoting bone formation, ideal anti-infection performance, and promoting the increase of bone density

Inactive Publication Date: 2016-12-14
SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] In view of the above-mentioned defects of the prior art, the technical problem to be solved by the present invention is how to design a device with strong antibacterial effect, no need for secondary operation to remove, not easily wrapped by tissue, no antibiotic resistance, channel and braided silk thread Construction of a magnesium-based metal anti-infection bead device that can provide good mechanical support for the magnesium-based metal bead

Method used

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  • Magnesium-base metal anti-infection chain bead device
  • Magnesium-base metal anti-infection chain bead device
  • Magnesium-base metal anti-infection chain bead device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Pure magnesium material. It is manufactured with high-purity raw materials and high-cleanliness smelting technology. Tensile strength 210Mpa, elongation 10%. After heat treatment and deformation processing, a pure magnesium metal wire with a diameter of 0.8mm and a length of 300mm, and a pure magnesium metal ball with a diameter of 10mm and three parallel channels with a diameter of 1mm and two non-penetrating semi-channels with a diameter of 1mm are produced.

[0037] biosecurity

[0038] Biological evaluation was carried out according to the experimental method described in GB / T16886. The experimental results show that the material of this example has no obvious cytotoxicity and blood coagulation to osteoblasts and bone marrow mesenchymal stem cells, and has no obvious sensitization, stimulation and genotoxicity.

[0039] antibacterial properties

[0040] Experimental strains were used: Staphylococcus epidermidis strain (S. epidermidis), methicillin-resistant Staphy...

Embodiment 2

[0042] Magnesium alloy is used, containing copper (Cu), by weight percentage. The percentage by weight is 0.5%.

[0043] It is manufactured with high-purity raw materials and high-cleanliness smelting technology. Tensile strength 250Mpa, elongation 12%. After heat treatment and deformation processing, a magnesium alloy metal wire with a diameter of 1mm and a length of 300mm is further produced, and a magnesium alloy metal ball with a diameter of 10mm and three parallel channels with a diameter of 1mm inside.

[0044] biosecurity

[0045] Biological evaluation was carried out according to the experimental method described in GB / T16886. The experimental results show that the material of this example has no obvious cytotoxicity and coagulation to osteoblasts and bone marrow mesenchymal stem cells, and has no obvious sensitization, stimulation and genotoxicity.

[0046] antibacterial properties

[0047] Experimental strains were used: Staphylococcus epidermidis strain (S. epi...

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Abstract

The invention discloses a magnesium-base metal anti-infection chain bead device which relates to the field of medical appliances and comprises chain bead bodies and a silk thread, wherein each chain bead body comprises a pore channel or parallel pore channels; the silk thread passes through the pore channel or the parallel pore channels; and the silk thread is configured to have a woven state outside the chain bead bodies and can connect the chain bead bodies in series. According to the invention, pure magnesium or magnesium alloy containing other anti-microbial constituents is made into the magnesium-base metal anti-infection chain bead device; the device can be used to implant chronic osteomyelitis anti-infection filler into a medullary cavity; bone-related infections such as chronic osteomyelitis can be treated effectively; recurrence of osteomyelitis can be prevented; and the device has very good clinical application prospect.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to a magnesium-based metal anti-infection bead device. Background technique [0002] Bone-related infections such as chronic osteomyelitis are common diseases in orthopedics and traumatology. Most of them are caused by improper or untimely treatment of acute suppurative osteomyelitis. As a result of chronic development of the disease, most of the systemic symptoms usually disappear. Only when the local drainage is not smooth, there are systemic symptoms. Symptoms are often localized, often stubborn and intractable, and even cannot be cured for several years or more than ten years. Fractures, bone defects, ankylosis, deformities, etc. can often occur concurrently, resulting in disability, amputation, or even canceration that endangers the life of the patient and brings great pain to the patient. [0003] The treatment of chronic osteomyelitis requires a combination of methods, the ma...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B17/56A61M31/00
CPCA61B17/56A61B2017/564A61M31/00
Inventor 戴尅戎毛震扬曲新华
Owner SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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