Artificial blood vessel inner wall coating decorated by mussel mucin, and preparation method and application thereof

A mussel mucin and artificial blood vessel technology, applied in the field of medical materials, can solve the problems of lumen occlusion and easy thrombosis, and achieve the effects of inhibiting local inflammation, reducing infection, and good histocompatibility

Inactive Publication Date: 2017-05-31
苏州医甸园医疗科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The invention creatively applies mussel mucin to artificial blood vessels, and uniformly prepares mussel mucin coating on the inner wall of artificial blood vessels, which can greatly enhance the antithrombotic ability of transplanted blood vessels, and significantly improve the performance of small-diameter artificial blood vessels. The usual rate solves the defects of the existing small-caliber artificial blood vessels that easily lead to lumen occlusion and thrombosis

Method used

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  • Artificial blood vessel inner wall coating decorated by mussel mucin, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] (1) Prepare an aqueous mussel mucin solution with a concentration of 0.5 mg / mL and a pH of 4.0;

[0021] (2) Fill a 20mL syringe with the mussel mucin aqueous solution, and connect the syringe to one end of the polyurethane artificial blood vessel. The mussel mucin aqueous solution was removed from the other end of the artificial blood vessel. The coated artificial blood vessel was dried at room temperature for 1 hour to obtain a polyurethane artificial blood vessel whose wall was modified by mussel mucin.

Embodiment 2

[0023] (1) Prepare an aqueous mussel mucin solution with a concentration of 1.0 mg / mL and a pH value of 6.0;

[0024] (2) Fill the 20mL syringe with the mussel mucin aqueous solution, and connect the syringe to one end of the expanded polytetrafluoroethylene artificial blood vessel. The excess mussel mucin aqueous solution was removed from the other end of the artificial blood vessel. The coated artificial blood vessel was dried at room temperature for 0.5 h to obtain an expanded polytetrafluoroethylene artificial blood vessel whose inner wall was modified by mussel mucin.

Embodiment 3

[0026] (1) prepare mussel mucin aqueous solution, concentration is 2.0mg / mL, pH value is 6.5;

[0027] (2) Fill a 20mL syringe with the mussel mucin aqueous solution, and connect the syringe to one end of the polyester artificial blood vessel. The mussel mucin aqueous solution was removed from the other end of the artificial blood vessel. The coated artificial blood vessel was dried at room temperature for 2 hours to obtain a polyester artificial blood vessel whose inner wall was modified with mussel mucin.

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Abstract

The invention discloses artificial blood vessel inner wall coating decorated by mussel mucin, and a preparation method and an application thereof. A mussel mucin solution coats an artificial blood vessel inner wall, and drying is carried out to obtain the artificial blood vessel inner wall coating; and an artificial blood vessel comprises a dacron artificial blood vessel, a real silk artificial blood vessel, an expanded polytetrafluoroethylene artificial blood vessel and a polyurethane artificial blood vessel. The artificial blood vessel inner wall coating disclosed by the invention can enhance the antithrombotic ability of graftted vessels to a great extent, obviously improve the patency rate of small caliber artificial blood vessels, and solve the defects that the existing small caliber artificial blood vessels are liable to cause lumen blockage and are liable to form thrombose.

Description

technical field [0001] The invention relates to a medical material, in particular to a mussel mucin-modified artificial blood vessel inner wall coating and a preparation method and application thereof. Background technique [0002] When the blood vessels in a certain part of the human body cannot guarantee the normal blood supply to the human body due to reasons such as aging, arteriosclerosis, embolism or damage, surgical operations such as artificial blood vessel replacement, bypass or intervention are required for treatment. At present, large and medium-caliber vascular grafts have achieved good clinical results, and long-term patency is ideal, but small-caliber (inner diameter less than 6mm) artificial blood vessels are prone to thrombosis or intima due to their slow blood flow and low blood pressure. Abnormal hyperplasia, resulting in low long-term patency rate after transplantation. Among them, the mismatch between host blood vessel and artificial blood vessel complia...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/34A61L27/22A61L27/50
CPCA61L27/34A61L27/22A61L27/507A61L2430/22C08L89/00
Inventor 宋智谦
Owner 苏州医甸园医疗科技发展有限公司
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