136 results about "Aspiration biopsy" patented technology

The present invention provides for x-ray imaging and ultrasound imaging of a body region of interest in a spatially correlatable manner. The resultant x-ray and ultrasound images may be combinatively employed to provide three-dimensional information regarding a location of interest within the body, and is particularly apt for use in the analysis / biopsy of potential lesions and suspicious masses in a female breast. The invention provides for direct body contact by an ultrasound imaging head, as well as targeted ultrasound imaging of a selected portion of the region from which x-ray images are obtained. A user interface system facilitates various procedures including ultrasound guided needle biopsy procedures.

The present invention provides for x-ray imaging and ultrasound imaging of a body region of interest in a spatially correlatable manner. The resultant x-ray and ultrasound images may be combinatively employed to provide three-dimensional information regarding a location of interest within the body, and is particularly apt for use in the analysis / biopsy of potential lesions and suspicious masses in a female breast. The invention provides for direct body contact by an ultrasound imaging head, as well as targeted ultrasound imaging of a selected portion of the region from which x-ray images are obtained. A user interface system facilitates various procedures including ultrasound guided needle biopsy procedures.

A biopsy needle scrapes tissue of cellular thickness from a lesion during repeated proximal-to-distal thrusts of the needle along its longitudinal axis of symmetry. A first sharp edge, formed by a beveled distal end of the needle, scrapes tissue during proximal-to-distal travel of the needle. A second sharp edge is provided by a transversely disposed slot formed in the needle near the first sharp edge. The second sharp edge also scrapes tissue during proximal-to-distal travel of the needle. The second sharp edge may be coincident with an exterior surface of the needle elevated with respect to the exterior surface, or recessed with respect to the exterior surface. Another embodiment includes a hinge for enabling pivotal movement of the second sharp edge.

The invention discloses a surgical navigation system for lung puncture. The surgical navigation system comprises a navigation workstation, an aspiration biopsy probe and a navigation waistcoat, wherein the aspiration biopsy probe and the navigation waistcoat are in data connection with the navigation workstation; the navigation workstation is provided with an electric control unit; the electric control unit is internally provided with an operating system and integration software; the integration software comprises a patient data management module, an image data three-dimensional visualization and processing module, a lung region partitioning module, a navigation configuration module, a pre-operation planning module, an operation rectification module, an operation guide module, a mathematical modeling module and a postoperation operative evaluation module. The surgical navigation system is used for performing early detection on suspected tumors in the whole lung region, and has the advantages of greatly improving the surgical precision, reducing the radiation dose, reducing the operation complexity, reducing postoperation complications, shortening the operation time and the like.

The invention provides a robot for aspiration biopsy of the prostatic gland, which is the prostatic aspiration biopsy equipment providing a cytologic diagnosis evidence for early-stage prostate cancer. The equipment comprises a computer system(1) for receiving and processing prostatic ultrasonograph data, a Motoman robot(3), a puncturing mechanism(4) and a driving device for a motor(6) of the puncturing mechanism(4), wherein the puncturing mechanism(4) is an end effector of the robot(3) and fixed at the tail end of the robot(3); the puncturing mechanism(4) consists of a DC servo motor(6), a base, two guide rails(7), a V-shaped belt(8), a front-end bearing seat(9), a needle-holding seat(10) and an electromagnetic launching device; the DC servo motor(6) is connected with the seat and can be disassembled by a V-shaped belt tightener (13); and the seat is arranged on the two guide rails(7) and connected with the V-shaped belt(8) by a belt clamping device(15). The robot can realize the accurate positioning, high efficiency, automation and informatization in a diagnostic process, so that the labor intensity of doctors is greatly lowered.

A tilted needle biopsy assembly is provided for mounting on an x-ray system. Because the biopsy needle is angied relative to at least one of the detector and the x-ray source, x-ray imaging may be performed during the biopsy procedure without interference by the biopsy device. The angled biopsy needle additionally allows improved access to the axilla and chest wall of the patient. The stereotactic biopsy device of the present invention may be coupled to any x-ray system, whether upright or prone, including but not limited to mammography systems, tomosynthesis systems, and combination mammography / tomosynthesis systems. The system flexibly supports the use of any mode of image capture (i.e., scout, two dimensional mammogram, three-dimensional reconstructed volume) for either or both target visualization and target localization. With such an arrangement, a needle biopsy assembly having improved patient coverage is provided for use with a variety of different x-ray imaging platforms.

The invention discloses an intraoperative information fusion method for ultrasonic images and aspiration biopsy needles under optical positioning. The method comprises steps as follows: intraoperative real-time ultrasonic images are collected by an ultrasonic image collection system; real-time spatial pose information of the aspiration biopsy needles for the operation is acquired by an optical tracking system; the intraoperative real-time ultrasonic images and the real-time spatial pose information are fused by an image processing work station; a real-time fusion result is displayed in a three-dimensional virtual environment, and accordingly, a relative position relation between the guided aspiration biopsy needles and ultrasonic image planes is reflected. According to the method, the relative position relation between the guided aspiration biopsy needles and the ultrasonic images in the three-dimensional space can be accurately reflected, operation guidance is performed through combination of pose information of the aspiration biopsy needles and intraoperative image information, the relative position relation of the aspiration biopsy needles and a focus is assisted in visualization in the three-dimensional virtual environment, and convenience and safety of the operation are improved.

The invention discloses a targeted trapping and sequencing kit for 285 lung cancer-related genes and application of the targeted trapping and sequencing kit. The kit is based on hybrid trapping of a probe, and can be used for preparing a high-throughput library of the lung cancer-related 285 genes and simultaneously detecting all variation loci on exons of the 285 genes, so that the disadvantagesof high cost, high time consumption, tedious operation and the like of conventional single-gene detection are overcome. Detection of a plurality of genes with a single small sample is implemented in the small sample for aspiration biopsy of lung cancer, and the clinical practice requirements of maximally using the small sample and obtaining a maximum amount of information are met. The kit is basedon an Ion Proton platform, has high accuracy and sensitivity, and has obvious advantages compared with a Sanger sequencing method, and a detection result in a residual DNA (deoxyribonucleic acid) sample of a paraffin sample is stable.

The invention discloses a plate type fixator for percutaneous kidney puncture biopsy. The plate type fixator comprises a fixed plate, an avoidance hole, a slide rail, a first insert hole, a clamping plate, a fixed sleeve, a first bolt, a first spring, a connecting plate, a second insert hole, a cutting ferrule, a second bolt, a second spring, a guide plate, a guide hole and an adjusting sleeve. The plate type fixator for percutaneous kidney puncture biopsy is skillful in structure and powerful in function. Firstly, by means of action of an adjusting guiding mechanism, the fixator can be adjusted conveniently according to an aspiration biopsy position of a patient, and the puncturing accuracy can be also improved greatly and the stability of a sucking and sampling process can be enhanced; secondly, by means of a matched effect of multiple fixed connecting mechanisms, the fastness of the device and the body of the patient is improved, the condition that the patient moves or the device isfar from the body of the patient is avoided, and finally, the success rate of the percutaneous kidney puncture biopsy is enhanced greatly, so that the fixator is favorably popularized and applied inmedical industry.

The intelligent thoracic cavity and abdominal cavity aspiration biopsy instrument includes one biopsy syringe, one connected outer biopsy needle tube with one liquid pumping nozzle, one biopsy needle seat and one inner biopsy needle tube inside the biopsy syringe and the outer biopsy needle tube, one handle with electrode wire connecting hole, and one locating pin. The biopsy syringe has liquid pumping location hole and biopsy location hole on one end; the biopsy needle seat has liquid pumping hole communicated with the inner biopsy needle tube and the liquid pumping nozzle, and the inner biopsy needle tube has sampling slot. The intelligent thoracic cavity and abdominal cavity aspiration biopsy instrument has one controller comprising power source, monolithic computer, programming port, aspiration biopsy needle electrode, chip electrode, etc. The present invention has accurate locating, high success rate and high safety.

The invention provides a method for separating and culturing primary hepatocyte. The method comprises the following steps: S1, performing aspiration biopsy on liver tissue so as to obtain a liver tissue sample, and crushing the liver tissue sample so as to obtain tissue fragments; S2, digesting the tissue fragments, and filtering so as to obtain a second tissue fragment; and S3, inoculating the second tissue fragment into a culture device, and performing multiplication culture. The method is low in liver tissue source requirement, wide in tissue source, small in operation risk, simple and feasible in step, high in operability, short in time and low in cost.

The invention discloses an automatic radiofrequency ablation negative pressure biopsy system. The automatic radiofrequency ablation negative pressure biopsy system comprises an outer sleeve pipe, an automatic negative pressure biopsy needle, a radiofrequency ablation needle, an injector, an insulating layer, a length scale indicator, a tail handle, a main body, an air pumping pipe, a blade guide rail groove, a soft connecting rod, a sharp blade, a cutter clamping buckle, a pressure sensor, a sampling opening and a spring. The automatic radiofrequency ablation negative pressure biopsy system largely improves the effective rate of pathological biopsy, and avoids needle passage bleeding and needle passage tumor planting to the maximum extent. The negative pressure biopsy system can guarantee that the activity of tissue is not polluted by bacteria, an ideal radiofrequency ablation effect is realized, operation is simple and rapid, and work intensity of medical workers is relieved.

The invention relates to a biopsy puncture needle component used for an orthopedics department. The biopsy puncture needle component used for the orthopedics department comprises a pipe sleeve, a puncture needle, a depth probe and a bone specimen clamping needle, wherein the pipe sleeve comprises a first handheld part and a needle tube, a first groove is formed in the upper part of the first handheld part, a boss is formed in the center of the first groove, a spiral sliding chute is formed outside the boss, one hole is formed in the center of the boss, a second groove group is arranged at the lower part of the handheld part and is used for holding the handheld part, the needle tube is fixed in the center of the second groove group and is communicated with the hole, the puncture needle comprises a first needle guard and a first needle core, a cone is arranged at the top of the first needle core, the depth probe comprises a second needle guard and a second needle core, the top of the second needle core is a plane, the bone specimen clamping needle comprises a third needle guard and a third needle core, and multiple clamping pieces are arranged at the top of the third needle core. The biopsy puncture needle component used for the orthopedics department has the beneficial effects that structure is simple, using effect is good, and the biopsy puncture needle component is innovation in needle biopsy instruments.

The invention belongs to the field of medicine and relates to a profile model for simulating the performance of the tumor contrast-enhanced ultrasonography and applied in the tumor diagnosis and treatment study. The profile model is characterized by comprising a tumor gel used for simulating a tumor, and a normal tissue gel used for simulating the surrounding normal tissue. The tumor gel comprises a nano micro-bubble ultrasonic contrast agent. The nano micro-bubble ultrasonic contrast agent is distributed uniformly, good in dispersibility, strong in imaging effect in vivo and in vitro, and better in stability in the high / low-frequency ultrasonic sound field. Therefore, the profile model facilitates the contrast-enhanced ultrasonic scanning process of a user, the practice of the tumor aspiration biopsy and the practice of the tumor ablation therapy with the help of the high / low-frequency ultrasonic guidance.

The invention provides a bone tissue aspiration biopsy needle core. The bone tissue aspiration biopsy needle core comprises a tubular needle core body, wherein self-tapping threads are arranged on the outer side wall of a piercing end of the needle core body; a zigzag convex edge is arranged at the piercing end of the needle core body and comprises a projected edge which is formed by extending a local region of a side wall of the needle core body along the direction parallel to the axis of the needle core body; the zigzag convex edge is provided with two inclined sides; and a cutting edge is arranged on the inclined side in the self-tapping thread screwing-in direction. The bone tissue aspiration biopsy needle core can be widely used for treating and diagnosing bone diseases.

The invention provides a technology and method for preparing high throughput needle biopsy tissue chip. The method comprises the following steps: collecting 42 residual paraffin-embedded tissue samples of needle biopsy of patients who have been diagnosed as the breast cancer patients through pathological examination on mammary gland needle biopsy tissues; taking the corresponding normal pathological HE stained sections as the guide, cutting the paraffin-embedded tissue sections (1mm to 4mm) corresponding to the cancer parts of the HE-stained sections, preparing paraffin-embedded tissue cores, preparing breast cancer needle biopsy tissue arrays by utilizing a tissue chip instrument, cutting paraffin into slices, and preparing paraffin-embedded tissue chip of breast cancer needle biopsy tissue. The prepared needle biopsy tissue chip can be applied to molecular medical research of related diseases such as immunocytochemistry, in-situ hybridization, and the like.

The invention discloses a biopsy needle based on a photoacoustic imaging technique, which comprises a needle tip wall, a laser filter membrane, incident optical fibers and laser absorption layers. The invention further provides a needle biopsy method which comprises the following steps that a target tissue image is acquired in real time by other imaging techniques; the biopsy needle is aligned with a target tissue and needled; laser is emitted into the incident optical fibers; a photoacoustic signal is acquired by an ultrasonic transducer; an imaging result of a tissue nearby the laser filter membrane at the needle tip and luminous spots at the laser absorption layers and the laser filter membrane are obtained by photoacoustic reconstruction; by combining with the other imaging techniques, the target tissue imaging result and a photoacoustic imaging result of the tissue nearby the needle tip are displayed alternately; an accurate position of the needle tip is supposed by using the luminous spots at the laser absorption layers and the laser filter membrane; and when the needle tip is accurately moved to a designated position, a target tissue sample is acquired or a drug is injected for treatment. The method can accurately acquire the position of the needle tip, reduces the needling difficulty greatly, relieves a pain of a patient, and is convenient to use and outstanding in effect.

The invention discloses a device for locating a CT (Computed Tomography)-guided percutaneous biopsy and seed implantation template. The device comprises a CT bed, a support, a first sliding rail, first sliding blocks, a first motor, a first screw rod, first nuts, a connecting plate, a second sliding rail, a second sliding block, a second motor, a second screw rod, a second nut, a moving plate, a third motor and a controller. The device for locating the CT-guided percutaneous biopsy and seed implantation template has the advantages of ingenious structure, powerful functions and simple operation; by using the device, the puncturing and locating accuracy can be greatly improved; moreover, the working efficiency of medical workers is improved.

The invention discloses an endoscopic biopsy apparatus which comprises a handle assembly, an outer tube, a limiting piece, a needle tubing and an inner core wire. The handle assembly is composed of an adjustment handle, an outer tube handle, a limiting ring, an operation handle, a scale core rod, a needle tubing operation handle and an inner core wire control handle. The adjustment handle, the limiting ring and the operation handle are all arranged on the scale core rod and connected into a whole through the scale core rod. The outer tube handle is arranged in the adjustment handle and connected with the outer tube. The outer tube is connected with the scale core rod. The needle tubing operation handle is connected with the operation handle in a screwed mode. The operation handle is connected with the limiting piece in an inserted mode. The needle tubing is composed of a needle point section at the far end and a needle body section behind the needle point section. The needle tubing is located in the outer tube. The needle point section penetrates out of the far end of the outer tube. The needle body section is fixedly connected with the needle tubing operation handle. The inner core wire penetrates into the needle tubing. The far end of the inner core wire goes beyond the needle point end, and the near end of the inner core wire is connected with the inner core wire control handle. The biopsy operation is greatly simplified, the success rate and safety of operation are improved, operators can be easily trained, and wide promotion is easy.

The invention belongs to the field of laser micro-manufacturing of medical apparatus and instruments, and relates to a medical needle with a micro-reflector structure on the surface and a preparation method thereof particularly. According to the medical needle with the micro-reflector structure on the surface and the preparation method thereof, a micro-reflector structure array with blend arc characteristic is machined on the surface of the medical needle through the laser micro-machining technology, the interaction force between the medical needle and soft tissues is decreased during the puncturing process, deformation and movement of the soft tissues are decreased, curve of the medical needle is decreased, the ultrasound visuality effect in the puncturing process is improved, and placing precision in the puncturing process is improved. The medical needle with the micro-reflector structure on the surface can be widely used in a minimally invasive surgery such as subcutaneous injection, local anesthesia, blood sampling, biopsy and radiotherapy, accurate placing of the medical needle in the puncturing process is achieved, and validity of minimally invasive interventional examination and therapy of the medical needle are improved.

The invention relates to an adjusting type medical template system. The adjusting type medical template system comprises a base, wherein a first lead rail and a first template component are arranged on the base; a first gliding platform moved along the first lead rail is arranged on the base, and a second lead rail is arranged on the first gliding platform; a second gliding platform moved along the second lead rail is arranged on the first gliding platform, and a vertical bracket perpendicular to the second gliding platform is arranged on the second gliding platform; a third lead rail and a third gliding platform vertically moved along the third lead rail are arranged on the vertical bracket, and one side of the third gliding platform is provided with a second template component which is moved in relative to the first template component. The adjusting type medical template system has the following advantageous effects: the second template component is moved in relative to the first template component, so as to change a needle inserting trace of a puncture needle, avoid obstacles in an operation, and exactly and effectively perform the aspiration biopsy operation or implantation operation; and thereby, the best aspiration biopsy and the treatment effect can be realized; the adjusting type medical template system is simple in operation, convenient to operate, and high in adjusting precision.

The invention relates to the technical field of immunohistochemical staining and particularly relates to a double-label immunohistochemical staining kit used for differential diagnosis of metastatic renal cell carcinoma. The kit comprises a DAB developing solution and a primary antibody formed by mixing a mixed solution of a PAX8 antibody and a CD10 antibody or / and an HRP enzyme-labeled secondary antibody. In order to overcome the disadvantages that the histological characteristics of the metastatic renal cell carcinoma are extremely easily confused with adrenal tumors, lung cancer, liver cancer, thyroid cancer and the like so that a definite diagnosis is not easy to make, a conventional immunohistochemical method is used for respectively detecting, more time and labor are consumed, the tissue amount of an aspiration biopsy specimen is not enough and the like, the same sensitivity and specificity when each antibody in the mixed antibody is singly stained are kept by using the method; and the double-label immunohistochemical staining kit also has the advantages that staining steps are few, the experiment time is short, the stability is high, an experiment result can be directly compared, and brought information amount is much higher than that of traditional single staining and the like, and especially has the remarkable advantages for biopsy pathological diagnosis with few specimen amounts.

The invention provides a method for processing form and elasticity information of a tissue and an elasticity detection apparatus. The method comprises the following steps of acquiring a form image and an elasticity image of the tissue, wherein the form characteristic information of the tissue is included in the form image; the elasticity characteristic information of the tissue is included in the elasticity image; fusing and displaying the elasticity image in the form image; determining a puncturing position according to the guide of a fused image, and puncturing the tissue for sampling. Through the elasticity detection apparatus, the elasticity characteristic information and the form characteristic information of the tissue can be acquired, so that the guide is jointly provided for the location of the puncturing position according to the additive fusion of the elasticity image and the form image; the accurate locating of a pathologic tissue can be realized, so that the reliability of aspiration biopsy is greatly improved.

One embodiment of a multifunction aspiration biopsy device includes a hub having a chamber for receiving a collected specimen, a vacuum source in communication with the hub chamber, a needle detachable from the hub and having an outlet in communication with the hub chamber, and a cover extending over a portion of the needle outlet for directing a specimen collected through the needle into the hub chamber in a direction that differs from a longitudinal axis of the needle. The hub chamber with collected specimen may be separated from the vacuum source and the needle and the specimen may be triaged within the hub chamber. Various embodiments of a collection container for receiving used needles are also disclosed.

The invention provides a positive risk prediction method and apparatus for prostate aspiration biopsy, which can predict the specific risk of the prostate aspiration biopsy positive so as to reduce the unnecessary clinical prostate biopsy. The positive risk prediction method of the prostate aspiration biopsy comprises the following steps: acquiring the age of a prostate cancer screening patient subjected to the prostate aspiration biopsy, a value of total prostate specificity antigens, a value of free prostate specificity antigen and a value of prostate volume, substituting the acquired data into the following equation, and solving a prostate aspiration biopsy positive risk prediction value of the patient, Logit(P)=ln(P / (1-P))=a+b*Age+c*tPSA+d*fPSA-e*PV, wherein P is the prostate aspiration biopsy positive risk prediction value greater than 0 and less than 1, Age is the age of the patient, tPSA is the total prostate specificity antigen, fPSA is the free prostate specificity antigen, PVis the prostate volume, and a, b, c, d and e are constants.

The invention discloses a high frequency tumor ablation system of gynecology. The high frequency tumor ablation system of gynecology consists of a negative pressure automatic biopsy needle and a radiofrequency ablation needle which are arranged in the same outer sleeve, and further comprises a body, a suction-pipe, a blade guide groove, a soft connecting rod, a sharp cutter, a cutter buckle, a pressure sensor, a sampling opening, and a spring; the high frequency tumor ablation system of gynecology is capable of greatly improving the effective rate of the pathological aspiration biopsy, and the occurrence of the needle tract bleeding and the needle tract tumor deposit is avoided to the greatest extent. The high frequency tumor ablation system adopts a negative pressure biopsy system to ensure that the activity of the testing tissue is not affected by bacteria, so that the ideal radiofrequency ablation effect can be achieved, the operation is simple and rapid, and the work intensity of medical workers is reduced.