54 results about "Biopsy sample" patented technology

The invention relates to a method and system for detecting cells of a first cell type (1) in a biopsy sample in which a plurality of cells of different cell types (2, 3) are present. The invention further relates to a device for carrying out a magnetic field measurement on cells of a biopsy sample that are labeled with magnetic nanoparticles. The method comprises the following method steps: carrying out tissue dissociation of the biopsy sample in order to singulate the cells present in the biopsy sample; supplying magnetic nanoparticles (11) to the singulated cells in order to selectively label the cells of the first cell type (1); removing the excess magnetic nanoparticles (11); introducing the cells into a microchannel (5), the microchannel (5) having a cross section which allows only one labeled cell (1) to pass through at a time; carrying out a magnetic field measurement in the microchannel (5) by means of a quantum magnetic field sensor (6) based on the F-center principle; and sorting out the labeled cells (1) after they have passed through the microchannel (5).

A method capable of determining a probability of a subject having one or multiple cancer tissues of origin is disclosed. The method includes inputting the expression profile of a miRNA set obtained from a biopsy sample such as serum sample of the subject into a classifier which is based on a machine learning model such as a support vector machine model. In certain embodiments, the method can be used to simultaneously determine the probability of the subject having each of multiple different cancer types, which can enhance the prediction accuracy.

The present application relates to the technical field of medical image intelligent diagnosis, and discloses a biopsy pathological image intelligent diagnosis classification method. The method collects digital pathological image data of biopsy samples, extracts morphological feature regions in the image as a basic analysis unit. A multi-scale feature fusion network is constructed, the basic analysis unit is input into a first feature extraction layer to obtain a primary feature atlas, spatial attention weighting is performed through a secondary feature extraction layer, and a fusion feature vector is generated. A dynamic classification threshold pool is established, a feature subspace is divided according to the dimension distribution of the fusion feature vector, and independent classification boundary parameters are allocated to each subspace. A pre-trained pathological knowledge graph is loaded, the fusion feature vector is matched with the node features in the graph in terms of similarity, and knowledge nodes with a matching degree exceeding a preset threshold are selected as auxiliary diagnosis basis. An initial classification label is generated based on the output result of the dynamic classification threshold pool and the auxiliary diagnosis basis, and a final diagnosis classification result is output.

A method is disclosed comprising providing a biological sample on a swab, directing a spray of charged droplets onto a surface of the swab in order to generate a plurality of analyte ions, and analysing the analyte ions.

Provided is a miniature biopsy device for use in a patient. The miniature biopsy device is configured to be operated remotely. store and collect a biopsy sample within the miniature device. Also provided is the related system configured to carry out such an operation. and the related methods for use in biopsies.

The present invention relates to a combination punch biopsy tool comprising both cutting means cutting a biopsy or sample from a cutaneous or mucosal surface, and a gripping part for catching and safe-handling of the biopsy or sample. In particular, the present invention relates to a punch biopsy tool for providing a skin or mucous membrane or tissue sample (15) comprising a cutting edge (1) and gripping means (2, 2a, 2b) for gripping a biopsy sample, wherein the cutting edge (1) is positioned at a first end of the punch biopsy tool, while the gripping means (2, 2a, 2b) are positioned at a second end of the punch biopsy tool, both the cutting edge (1) and the gripping means (2, 2a, 2b) are secured to a central body.

Systems, methods, and devices, for melanoma pathology using one or more neural networks (NNs). The techniques described herein may include receiving molecular data corresponding to a patient biopsy sample; molecular data; encoding molecular output data according to a preselected encoding scheme; receiving image data corresponding to the patient biopsy sample; applying the image data to an image analysis NN; concatenate the encoded molecular data to the image data at an intermediate layer of the image analysis NN; and producing, based on the encoded molecular information and the image information concatenated at the intermediate layer, a prognosis output from the image analysis NN. Many other features and examples are described herein.

An ultrasonic endoscope assembly (110) has an endoscope (111) defining one or more lumens and a needle (114) that can be pushed forward from a lumen to collect a biopsy sample. An ultrasonic subassembly (120) is attached to the endoscope (111) and includes a communication cable (126) including a set of conductors having a distal end and an ultrasonic imaging head (122) connected to the distal end of the cable. Further included is an imaging head movement subassembly (140) including a conduit (148) releasably connected to the endoscope. The conduit houses a tension member (144) that is releasably connected to the imaging head (122). Thus, the imaging head movement subassembly (140) can be released from the cable and imaging head after use for disposal.

The invention relates to a biopsy sample flattening, fixing and embedding box and a use method thereof, belongs to the technical field of medical instruments, solves the technical problem of standard storage, fixing and embedding of biopsy samples, and adopts the technical scheme that a box body is detachably clamped in the embedding box and comprises a hollow inner cavity, a through hole is formed in the head end of the upper top surface of the box body and communicated with the inner cavity, and the through hole is communicated with the inner cavity; a guide plate is arranged above the through hole in a covering manner; the flattening fixing plate is detachably installed on the bottom face of the inner cavity, the sliding plate is placed above the flattening fixing plate, and the sliding plate slides in the length direction of the inner cavity; a biopsy sample to be flattened is placed in the box body through the through hole, one end of the biopsy sample to be flattened is pasted on the first pasting fixing layer at the head end of the flattening fixing plate, and the other end of the biopsy sample to be flattened is pasted on the second pasting fixing layer at the head end of the sliding plate. The device is simple in structure, convenient to operate, time-saving, labor-saving and standard, ensures that the mucous membrane surface, the intrinsic layer and the mucous membrane muscle layer are fully exposed when a biopsy sample is fixed, meets the requirements of pathological diagnosis, and avoids missed diagnosis and misdiagnosis.

1. The name of the design product: the main body of biopsy needle. 2. The use of the design product: the whole is used for the tool of obtaining the biopsy sample or cell sample from the patient's body for the pathological examination of the pathologist, and the protected part is used for the main body of the biopsy needle. 3. The design points of the design product: the shape of the protected part. 4. The picture or photo that can best show the design points: perspective view 1. 5. Other circumstances that need to be explained: the dotted line in the figure is not the part to be protected.

The invention relates to the technical field of medical image processing, in particular to a lupus nephritis curative effect prediction system based on multi-staining kidney biopsy pathological images. The system comprises a feature extraction module used for extracting image features of staining biopsy images of patients, a similarity analysis module used for distinguishing reference patients from non-reference patients according to the image features, a data preparation module used for forming training samples, and a data processing module used for processing the training samples. And the prediction module is used for performing model training based on the training data and predicting the healing probability of the target patient. According to the scheme, the model can be helped to pay more attention to training data of biopsy samples which are similar to biopsy samples of a target patient and are effectively different from biopsy samples of other reference patients, the characteristic of high heterogeneity existing in lupus nephritis is matched, the information mining effect of the biopsy sample image of lupus nephritis is improved, and the accuracy of the biopsy sample image of lupus nephritis is improved. And a doctor is assisted to accurately complete evaluation of specific typing and severity of lupus nephritis of a patient.

The invention relates to the technical field of medical auxiliary instruments, in particular to a nail and breast surgery biopsy sample preservation device which comprises a protection shell, a plurality of L-shaped supporting plates are arranged on the inner wall of the protection shell, through holes are formed in the short edges of the L-shaped supporting plates, supporting columns are arranged in the through holes in a sliding fit mode, and push plates are fixedly connected to the ends, close to the inner wall of the protection shell, of the supporting columns. Springs sleeving the supporting columns are arranged on the sides, close to the supporting columns, of the push plates, and the other ends of the springs are fixedly connected with the L-shaped supporting plates; arc-shaped clamping blocks are arranged at the other ends of the supporting columns; rotating shafts corresponding to the pushing blocks in number are arranged on the inner wall of the protective shell and are rotationally connected with pushing assemblies located below the long edges of the L-shaped supporting plates and used for pushing the pushing plates. The invention aims to realize full-process protection of abnormal posture-automatic clamping-stable resetting through a mechanical linkage structure, so that the stability and safety of a sample tube in a transfer process are improved, and the preservation requirements of high integrity and low pollution risk of clinical samples in the department of thyroid and breast surgery are met.

The utility model relates to a biopsy sampling and positioning system. The biopsy sampling and positioning system comprises a sampling assembly and an auxiliary positioning assembly, wherein the sampling assembly comprises a sheath tube and an inner core, and a sampling structure is arranged at the front ends of the inner core and the sheath tube; the auxiliary positioning assembly comprises a positioning locking piece which is adjustably arranged on the sheathing canal in the length direction of the sheathing canal; the scale plate is provided with a first containing groove used for containing the sheathing canal and a second containing groove used for containing the positioning locking piece, the scale plate is further provided with scale marks arranged in the length direction of the first containing groove, and the second containing groove is communicated with the first containing groove and located at the starting end of the scale marks; and the optical navigation component comprises a reference frame arranged on the sheathing canal and an optical ball fixed on the reference frame. According to the scheme, the sampling length can be calibrated in advance, so that a sampling structure can quickly and accurately reach a focus part, the quick positioning of a sampling assembly is completed, accurate navigation can be performed, the visual operation of sampling is realized, and the sampling operation is more refined.

The present invention belongs to the technical field of immune cell culture, and specifically relates to a composition and kit for expanding tumor infiltrating lymphocytes, and an expansion method therefor. Provided is a composition for expanding tumor infiltrating lymphocytes for a trace amount of tumor tissue, i.e., a tumor biopsy sample, to perform the expansion of tumor infiltrating lymphocytes, which solves the problem that a large amount of a tumor tissue sample is required for tumor infiltrating lymphocytes, and is suitable for patients who cannot undergo surgical resection to obtain tumor tissue. In addition, by means of optimizing the combination and working concentration of antibody stimulants, a process flow for expanding tumor infiltrating lymphocytes on the basis of biopsy samples is established, such that the stemness of the expanded tumor infiltrating lymphocytes is maintained, and the killing ability is improved, thereby ensuring the anti-tumor efficacy after reinfusion into the body.

Disclosed herein is a method for enhancing antitumor T cell responses in subjects. The method involves administering to the subject in need thereof a composition comprising a demethylating agent in an amount effective to demethylate STING proteins in the tumor cells. This method is particularly useful in subjects with deficient STING expression in the tumor cells. Therefore, also disclosed is a method for treating a tumor in a subject that involves detecting in a biopsy sample from the subject reduced STING expression, reduced cGAS expression, or a combination thereof; and then administering to the subject a demethylating agent in an amount effective to demethylate STING proteins in the tumor cells. The method can further involve administering to the subject a therapeutically effective amount of a STING agonist. The method can further involve administering to the subject tumor infiltrating lymphocytes (TILs), such as HLA-matched TILs.

The invention belongs to the technical field of immune cell culture, and particularly relates to a tumor infiltration lymphocyte amplification composition, a kit and an amplification method thereof. The invention provides the tumor infiltration lymphocyte amplification composition aiming at a trace amount of tumor tissue, namely a tumor puncture sample, the tumor infiltration lymphocyte amplification composition is used for amplifying the tumor infiltration lymphocyte, the problem that the tumor tissue sample size required by the tumor infiltration lymphocyte is large is solved, and the tumor infiltration lymphocyte amplification composition is suitable for a patient who cannot receive the tumor tissue obtained by surgical excision. Besides, by optimizing the antibody stimulant combination and the working concentration and establishing the technological process for amplifying the tumor infiltration lymphocytes based on the puncture sample, the dryness of the tumor infiltration lymphocytes obtained through amplification is maintained, the lethality is improved, and therefore the anti-tumor curative effect after the tumor infiltration lymphocytes are infused back into the body is guaranteed.

A method for automating margin measurement for mass removal that utilizes one or more machine learning models is disclosed. The one or more machine learning models may assist in identifying and segmenting each biopsy in an image, classifying the biopsy as a clear biopsy or an ambiguous biopsy, rotating the image of the biopsy to a proper orientation, and identifying and segmenting the skin and tumor found in the image of the biopsy. The method may then determine a lateral and deep margin value and display the values on the image.

The invention discloses a protein marker for differential diagnosis of intestinal extracorporeal natural killer / T cell lymphoma and application of the protein marker. The protein marker is composed of COL6A3 and MFAP2 protein. Or the protein is composed of ADAMTS4, COL6A3 and MFAP2 protein. The invention also provides application of a reagent for detecting the protein in preparation of a kit for diagnosing intestinal natural killer cell / T cell lymphoma or evaluating the occurrence risk of the intestinal natural killer cell / T cell lymphoma. According to the invention, the technical bottleneck of difficulty in pathological diagnosis caused by superficial endoscopic biopsy sample of the intestinal ENKTL is effectively solved, and ENKTL can be accurately identified from ulcerative colitis, diffuse large B-cell lymphoma and colon cancer. The method is simple and convenient to operate, the selected antibody is strong in signal and clear in background in IHC detection, a quantitative result with good repeatability and high specificity can be obtained by combining an H-score scoring system, and objectivity and accuracy of pathological diagnosis are remarkably improved.

The utility model relates to a biopsy sampling host, a vacuum joint and biopsy sampling equipment, the vacuum joint and a connecting hose are integrally arranged in a mounting through hole in a penetrating manner, and a second positioning part on the vacuum joint is positioned and matched with a first positioning part on the inner side wall of the mounting through hole in the process that the vacuum joint moves along the insertion direction; therefore, the vacuum connector cannot continuously move in the insertion direction, the second limiting part, the connecting hose and the first limiting part are matched in a limiting mode through pretightening force in the pulling-out direction of the vacuum connector, the vacuum connector cannot move in the pulling-out direction, and then insertion and pulling-out of the vacuum connector relative to a machine body are stably and reliably restrained. When the vacuum connector needs to be maintained or replaced, the vacuum connector can be pulled out of the mounting through hole to be maintained or replaced only by applying acting force larger than pre-tightening force to the vacuum connector in the pulling-out direction, dismounting is convenient and simple, and therefore the vacuum connector has the advantages of being stable in mounting and convenient to dismount.

Medical devices, systems, and methods described herein may be useful for performing a biopsy medical at a target tissue site within a patient and removing a biopsy sample from the target tissue site. The medical device includes a probe that includes a lumen, and a handle in fluid communication with the probe. The handle including a body defining a chamber coupled to the probe and configured to receive a canister containing a fluid, and an actuator configured to transition a valve from a closed position in which the probe is not in fluid communication with the handle and into an open position in which the probe is in fluid communication with the handle.

1. The name of the design product: kidney biopsy sample grading and separating device. 2. The use of the design product: for grading and separating kidney biopsy samples. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view.

The application provides a fresh biopsy sample diffusion coefficient measurement method and device, the method comprises: enhancing the susceptibility of water molecules in the fresh biopsy sample; after the water molecules in the fresh biopsy sample are magnetically saturated, exciting the water molecules in the fresh biopsy sample to spin; collecting the magnetic resonance signal strength of the spin magnetic moment evolution of the water molecules in the fresh biopsy sample; and determining the diffusion coefficient according to the magnetic resonance signal strength. The application enhances the susceptibility of water molecules in the fresh biopsy sample and excites the water molecules to spin, thereby achieving the effect of enhancing the water molecule magnetic resonance signal, and then collecting the magnetic resonance signal strength of the spin magnetic moment evolution of the water molecules to determine the diffusion coefficient, so that the fresh biopsy sample can be quantitatively measured in terms of diffusion coefficient with high spatial resolution and high imaging efficiency on a low-field nuclear magnetic resonance imaging instrument.

FIELD: medicine.SUBSTANCE: method for controlling a device for taking a biopsy sample and a device for taking a biopsy sample. The device contains first and second motors, a controller connected to them, and outer and inner cutting tubes. The outer cutting tube is placed on the inner cutting tube. A sampling window is located on the side of the front end of the outer cutting tube. In this case, a sample taking command is received to control the operating states of the first and second motors to set the inner cutting tube in motion relative to the outer cutting tube to perform sample taking. The first motor is controlled to drive the inner cutting tube in the axial direction to the sample taking position. The first and second motors are controlled to cause the inner cutting tube to move forward and rotate until the inner cutting tube reaches a position where it covers the sampling window. The first motor drives the inner cutting tube into movement in the axial direction, and the second motor drives it into rotation around the axis of the inner cutting tube. The directions of rotation of the inner cutting tube around the axis are opposite during two consecutive sample takings.EFFECT: internal cutting tube is prevented from becoming entangled in the tissue during sample collection, which reduces the frequency of system failures and improves work efficiency.14 cl, 13 dwg

The utility model relates to a biopsy sampling main machine and biopsy equipment, when a collecting container is placed in a placing groove, a cover body moves to a closing position for closing the placing groove relative to a main machine body, and at the moment, the cover body is supported by a supporting piece, so that a vertically upward supporting force is provided for the cover body; even if the top of the cover body is subjected to gravity or external acting force, the top of the cover body cannot sink relative to the top of the main machine body, the appearance quality of the biopsy sampling main machine is guaranteed, and sealing of an internal collecting container cannot be affected.

Processes and materials to detect neoplasms from a biopsy are described. Processes and materials to build a sequencing library are described. Processes and material to perform targeted sequencing are described. Processes and materials to mitigate confounding sources are described. Cell-free nucleic acids can be sequenced and the sequencing result can be utilized to detect sequences derived from a neoplasm.

Disclosed herein is a method for enhancing antitumor T cell responses in subjects. The method involves administering to the subject in need thereof a composition comprising a demethylating agent in an amount effective to demethylate STING proteins in the tumor cells. This method is particularly useful in subjects with deficient STING expression in the tumor cells. Therefore, also disclosed is a method for treating a tumor in a subject that involves detecting in a biopsy sample from the subject reduced STING expression, reduced cGAS expression, or a combination thereof; and then administering to the subject a demethylating agent in an amount effective to demethylate STING proteins in the tumor cells. The method can further involve administering to the subject a therapeutically effective amount of a STING agonist. The method can further involve administering to the subject tumor infiltrating lymphocytes (TILs), such as HLA-matched TILs.

The present application relates to the technical field of medical image processing, and particularly relates to a lupus nephritis curative effect prediction system based on multiple staining kidney biopsy pathological images. The system comprises: a feature extraction module for extracting image features of a staining biopsy image of a patient, a similarity analysis module for distinguishing reference patients from non-reference patients according to the image features, a data preparation module for forming training samples, and a prediction module for training a model based on the training data and predicting the cure probability of a target patient. The present scheme can help the model pay more attention to the training data that is similar to the biopsy sample of the target patient and effectively distinguishes the biopsy sample of the target patient from other reference patients, matches the characteristics of high heterogeneity of lupus nephritis, improves the information mining effect of the biopsy sample image of lupus nephritis, and assists doctors in accurately completing the specific typing and severity assessment of lupus nephritis of the patient.

Processes and materials to detect cancer, transplant rejection, or fetal genetic abnormalities from a biopsy are described. In some cases, cell-free nucleic acids can be sequenced, and the sequencing result can be utilized to detect sequences indicative of a neoplasm, transplant rejection, or fetal genetic abnormality. Detection of somatic variants occurring in phase and / or insertions and deletions (indels) can indicate the presence of cancer, transplant rejection, or fetal genetic abnormalities in a diagnostic scan, and a clinical intervention can be performed.

The invention discloses a lung cancer vascularized organ and application thereof in mouse tumor formation model and drug screening, and belongs to the technical field of biomedicine and drug research and development. A preparation method of a lung cancer vascularized organoid comprises the following steps: taking a lung cancer tissue or a needle biopsy sample, and treating with tissue digestive juice to obtain single cells or tissue fragments; embedding the single cells or tissue fragments obtained in the step 1 with matrigel, and placing the single cells or tissue fragments in a special lung cancer culture medium containing EGF, FGF and Wnt growth factors to form lung cancer organs; and adding two pro-vascularization factors, namely VEGF and Angiopoietin-2, into the lung cancer organoid culture system in the step 2, so as to obtain the lung cancer vascularization organoid. The method solves the problems that traditional organoid lacks a functional vascular network and is insufficient in physiological correlation, provides a more accurate research tool for lung cancer disease modeling and drug screening, and can be widely applied to the fields of accurate medicine, oncology research and new drug research and development.