58 results about "Fine-needle aspirate" patented technology

A medical instrument usable with an ultrasound-endoscope for performing a needle biopsy on a patient's internal body tissues usable at a surgical site not visible to the unaided eye or viewed endoscopically, comprises an elongate tubular member with a hollow needle element connected at its distal end, a sheath member housing said tubular member and needle element, an actuator subassembly with a shifter member operatively connected to elongate tubular member's proximal end, and a distal camming subassembly, said subassembly enabling a rotating motion of said needle member while handle actuator is moved in the forward direction. Upon inserting an ultrasound-endoscope into a patient and locating a mass, the fine needle with sharply pointed spoon shaped distal end is inserted into the mass aided by endoscopic and ultrasonographic guidance. Once in the mass, a camming action is initiated, causing rotation of the fine needle within the mass, resulting in a scooped out core biopsy. This instrument enables the performance of a fine needle aspiration requiring only one or two needle introductions, with a resultant core biopsy substantial enough for diagnostic purposes.

A notched tissue-collection needle configured similarly to a fine-needle-aspiration needle is provided with a cutting edge disposed in the notch and configured to excise tissue into the notch for collection. A stylet may be provided through a lumen of the needle during introduction into a patient body. The needle may be provided with echogenicity-enhancing features.

A biopsy device is disclosed. The biopsy device disclosed includes an outer cutting cannula and an inner cannula. The inner cannula has a side sample port for receiving a biopsy sample. The outer cannula can be selectively positioned with respect to the side port to provide fine needle aspiration sampling or, alternatively, core biopsy sampling.

The present invention provides a method for classification of thyroid tumors through the analysis of the expression patterns of specific microRNAs in fine needle aspiration samples. Thyroid tumor classification according to a microRNA expression signature allows optimization of diagnosis and treatment, as well as determination of signature-specific therapy.

A miniature ingestible capsule has multiple therapeutic or diagnostic operations that can be performed. These functions are controlled by a combination of an outside control, a pose beacon and through information relayed from an imagining array and transmitter. These functions can be in a separate capsule without an imaging array or within the same capsule with an imaging array. Typically, there is one function performed in addition to imaging. These functions can include suction and spray capabilities, ultrasound sensor, lithotripsy, laser, heat, electrocautery, BICAP, biopsy forceps, a needle knife snare cautery (cold and hot with continuous or pulsed current for cutting and coagulation), with a basket, and fine needle aspiration with various wheels and fins and motors controlled externally and other tools to be used in humans. All of these tools can be attached to a retractable arm. Also, they can be used on an elevator device that lifts them, allowing for an extra 180° of movement.

A notched tissue-collection needle configured similarly to a fine-needle-aspiration needle is provided with a cutting edge disposed in the notch and configured to excise tissue into the notch for collection. A stylet may be provided through a lumen of the needle during introduction into a patient body. The needle may be provided with echogenicity-enhancing features. A coated-wire sheath through which the needle is slidably disposed includes an overcoating that is thicker along a distal length and thinner along a proximal length.

A tri-point tissue-collection needle configured similarly to a fine-needle-aspiration needle is configured to excise intact tissue cores for collection. The distal tip is configured with three beveled points separated by cutting edges, where a single longer/more distal point is trailed by and circumferentially separated from a symmetrical pair of points, providing a bilaterally symmetrical needle cannula distal end. A stylet may be provided through a lumen of the needle during introduction into a patient body, where the distal end surface of the stylet may be configured to complement the tri-point needle end configuration.

The present invention relates to methods, compositions and articles directed to diagnosing thyroid carcinoma, differentiating between thyroid carcinoma and benign thyroid diseases, testing indeterminate thyroid fine needle aspirate samples of thyroid nodules, and determining patient protocols and outcomes.

The invention discloses a dispensable continuous negative-pressure puncture outfit, which comprises a needle tube and a puncture needle, wherein a pintle is arranged in the needle tube; a stopping device is arranged between the puncture needle and the needle tube; at least one chute is arranged on the pintle axially; chute lateral plates are arranged on two sides of the chute; at least the chute plate on one side is provided with a locking groove; a locking clip is arranged on the end, in which the pintle is inserted, of the needle tube and can move up and down in the chute; and when the pintle is rotated, the locking clip is clipped in the locking groove to clip the pintle to prevent the pintle from moving down. Compared with the prior art, the puncture outfit has the advantages that: the structure is simple, the operation is convenient and ample sample can be accurately positioned and acquired, so the accuracy of fine needle aspiration cytopathologic diagnosis is improved greatly; the puncture time is reduce, pains suffered by patients are reduced, and an operator can concentrate to ensure puncture accuracy; and the drawback that the negative pressure is maintained by the traction force of the hand of the operator of the traditional puncture outfit is radically overcome, the operation is more flexible and quicker than the traditional puncture method, and a good needle feel is offered.

An arrangement for taking a sample of cells from a suspicious lesion or a tumour with the so called fine needle aspiration technique, provides a good penetration of tumours, especially small and/or hard fibrous tumours, and in the meantime yielding an increased amount of cells in the sample, by applying a longitudinal movement to the needle when the needle is penetrating the tumour and by applying both a rotational and a longitudinal movement to the needle when the needle is positioned inside the tumour. The arrangement is further provided with heat generating elements in order to apply a short pulse of heat to the needle in order to lower the risk for the tumour to spread.

Methods and reagents are provided for the rapid extraction of nucleic acids from a cell or tissue sample. In certain embodiments the sample comprises a formalin fixed paraffin embedded sample (e.g., aFFPET sample), or a fine needle aspirate and/or a cell/tissue smear. In some embodiments, the methods comprise incubating one or more sections of said tissue sample in a lysis solution comprising a buffer sufficient to maintain the pH of said solution at a pH ranging from about pH 4 to about pH 9; a chaotropic agent; a chelating agent; and a detergent; where the incubating is at a temperature ranging from about 50 DEG C to about 100 DEG C; and recovering the nucleic acid from said lysis solution.

The present invention discloses an all-in-one fine needle aspiration means (FNA) for precision guidance and improved control of needle for ease of insertion, manipulation and efficient extraction of sample and a method thereof. Said FNA comprises means selected from a mechanically or electronically stabilized effecter; a mechanical or automated needle insertion and manipulation mechanism; optical means; a mechanical or automated vacuum or suction mechanism; and a biopsy collection receptacle.

A system and method for fine needle aspiration includes a plurality of components. A device includes a body unit, a trigger unit, and at least one gear. The body unit is configured to hold a syringe, and the trigger unit is configured to laterally move relative to the body unit in order to extend and retract a plunger within the syringe. The at least one gear is configured to engage the syringe so that lateral movement of the trigger unit causes rotation of the syringe. A needle includes a distal tip with a vertical edge extending from a distal end to a proximal end, and a curved edge running from the distal end to the proximal end. A syringe kit includes a stylet connected to the plunger. The stylet includes an outer diameter equal to an inner diameter of the needle.

A device for gathering tissue samples includes a needle defining a distal tissue penetrating tip. The needle includes an increased diameter proximal portion extending proximally from the distal tip. An outer diameter of the distal tip is smaller than an outer diameter of the proximal portion. The needle defines a lumen extending therethrough from a distal opening in the distal tip thereof to a proximal opening at a proximal end thereof. The lumen includes a distal portion having a first inner diameter and a proximal portion having a second diameter greater than the first diameter. The device also includes a stylet slidably received within the lumen. An outer diameter of a distal portion of the stylet is substantially equal to the inner diameter of the distal portion of the lumen so that, when the stylet is in an extended position extending to the distal opening of the lumen, the lumen is substantially sealed thereby, and when, in a retracted position in which a distal end of the stylet is received within the proximal portion of the lumen, an annular space surrounding the stylet defines an aspiration path for samples exiting the distal portion of the lumen.

Fine needle arrangement for taking a sample of cells from suspicious lesions by using fine needle aspiration (FNA) technique, including a tubular needle member (1), a storage compartment (2) enclosing a chamber, and a coupling (3) to which a connector may be attached. The chamber is configured with a gradually increasing cross-sectional area from the distal part of the chamber to the proximal part of the chamber, such that the chamber has no residual spaces where cell samples may be trapped, and that an efficient air streaming is achieved.

The present invention provides specific nucleic acid sequences for use in the identification, classification and diagnosis of various sub-types of lung cancers. The present invention permits one to accurately classify lung cancers based on their miR expression profile without further manipulation. Using microRNA microarray data generated from over two hundred formalin-fixed paraffin-embedded (FFPE) resection samples, fine needle aspiration (FNA) samples and fine needle biopsy (FNB) samples of primary lung cancer, microRNA expression profiles were identified that differ significantly for various sub-types of lung cancer.