15 results about "Fine-needle aspirate" patented technology

To improve allele discrimination, the inventors adapted the system combining Cas13a detection sensitivity with allele-specific PCR amplification to propose CASPER (Cas13a Allele-Specific PCR Enzyme Recognition) as a new versatile, easy-to-implement, and highly sensitive method to detect low-frequency of sequence variant. CASPER enabled specific and sensitive detection of KRASG12D with low DNA input such as DNA extracted from patient's pancreatic ultrasound-guided fine-needle aspiration fluids. CASPER is easy to implement and a versatile reliable method virtually adaptable to any point mutation.

A thyroid fine needle puncture suction biopsy needle comprises a needle tube and a pressure control component. The pressure control component comprises a main body structure, a connecting part and a valve assembly, a pressure control cavity is formed in the main body structure, and the pressure control cavity can communicate with the interior of the needle tube through the connecting part; a vent hole communicated with the outside is formed in the main body structure, the valve assembly is located between the vent hole and the pressure control cavity, the valve assembly is connected with an operating hand button, and the operating hand button is used for controlling the valve assembly to be switched between an open state and a closed state; in the closed state, the valve assembly separates the pressure control cavity from the vent hole, and in the open state, the valve assembly is opened, so that the needle tube is communicated with the outside atmosphere through the pressure control cavity and the vent hole. According to the utility model, large negative pressure cannot be generated, so that a large amount of blood is prevented from being sucked, the proportion of the obtained nodule cell quantity is high, the pathological diagnosis rate is higher, the cell quantity of single puncture is increased, the risk of tumor needle passage metastasis is reduced, and the utility model belongs to the technical field of medical instruments.

The invention relates to the technical field of medical diagnosis, in particular to a papillary thyroid carcinoma diagnosis method based on hsacirc0076710 and a kit. The invention provides a papillary thyroid carcinoma detection kit based on hsacirc0076710, the expression condition of circular RNA hsacirc0076710 in a living body can be accurately and rapidly detected, a new gene detection means can be provided for early diagnosis and prognosis of papillary thyroid carcinoma, meanwhile, the invention provides a papillary thyroid carcinoma diagnosis method based on hsacirc0076710, and the papillary thyroid carcinoma detection kit can be applied to diagnosis of papillary thyroid carcinoma. According to the method, diagnosis is carried out by detecting the expression level of hsacirc0076710 in a sample, the areas (AUC) under an ROC curve in tissue, a fine needle biopsy eluent and a serum sample are 0.851, 0.838 and 0.769 respectively, and the sensitivity reaches 83.7%-95.1%. Further analysis shows that the hsacirc0076710 has high expression and high expression of lymph node metastasis (OR = 3.21, plt; 0.001) and advanced TNM (stage III / IV), and can be used for early diagnosis and prognosis risk assessment of papillary thyroid carcinoma.

A catheter-based biopsy system integrates real-time optical coherence tomography (OCT) imaging with a multi-degree-of-freedom biopsy needle for precise tissue sampling within luminal organs. The system comprises a segmented handle, an outer sheath, a steerable needle, and an imaging stylet housed within the needle. The imaging stylet includes a metasurface-based optical lens for acquiring cross-sectional images through an imaging window in the needle. Independent handle segments control the extension of the needle and the positioning of the imaging stylet. The system supports multiple operational modes, including imaging, image-guided biopsy, and tissue retrieval, with optional encoder-based tracking for enhanced navigation. The integrated design enables targeted fine needle aspiration and biopsy under direct visualization, improving diagnostic accuracy and procedural efficiency.

Disclosed is a method for examining cells including: acquiring image data of cells acquired from a region suspected to be a cancer lesion; analyzing the image data; determining whether an amount of the cells is sufficient based on the analyzed result; and determining whether cancer-probable cells are included in the cells based on the analyzed result and the determined result; wherein the cells are acquired through Fine Needle Aspiration (FNA).

The present disclosure provides methods for expanding TIL populations from fine needle aspirates (FN As) or small biopsies which contain low numbers of TILs, using the methods disclosed herein including in a closed system that leads to improved phenotype and increased metabolic health of the TILs in a shorter time period.

A fine needle biopsy device includes an outer housing having a distal end and a needle connector that is connected to the distal end of the outer housing. The needle connector is configured to connect to a needle. A vacuum chamber is carried by the outer housing and fluidly connected to the needle connector. An inner housing is slidably received within an opening through the outer housing. A motor is carried by the inner housing. The motor is operably connected to the needle connector by a drive shaft that extends into the vacuum chamber. The inner housing moves axially relative to the outer housing to move the drive shaft between a release position and an aspiration position.

The present invention discloses a screening method for cell slide smear specimens for thyroid fine needle examination, the method comprising a diagnostic model generation step (S110); a specimen smearing step (S120), a tomographic image acquisition step (S130), a classification step (S140), and a diagnostic stage determination step (S150), in which first image data (A), which provides optimal information suitable for diagnosing papillary thyroid carcinoma from the same specimen image, and second image data (B), which is unsuitable for diagnosis, and a dataset on results of papillary thyroid carcinoma diagnosis stage determination based on feature analysis between the first image data (A) and the second image data (B) are pre-trained, whereby both clear and blurred tomographic images can be utilized in the diagnostic determination.

Identifying a fibroblast subtype in a thyroid cancer involves obtaining a fine needle aspiration (FNA) biopsy sample from a subject, the sample including nucleic acids; assaying the nucleic acids in the sample for an increase in the amount of mRNA produced by genes of a fibroblast gene signature relative to a control level of mRNA produced by the genes in a sample obtained from a healthy subject; and identifying the fibroblast subtype if there is an increase in the amount of mRNA in the sample relative to the control level.

An automated rapid on-site evaluation (ROSE) system for smearing, staining and capturing a digital image of a biological sample such as a fine needle aspiration (FNA) sample is presented. The system comprises a housing with a user interface monitor or screen, a smearing system, a staining system, and an image capture system. The housing can further include a receiver for a biological sample that can direct the sample to a sample slide. The smearing system is configured to smear the sample on the sample slide. The staining system is configured to stain the sample. The image capture system is configured to capture a magnified image of the sample and store the digital image in the housing or remotely. The digital images may be available immediately for local or off-site review. The wait time between staining the sample and image capture can be less than 60 seconds.

The thyroid fine needle aspiration biopsy equipment comprises a needle cylinder, a needle head and a sampling piston, a connecting hose is arranged on the needle head, a rigid fixing sleeve in sliding connection is arranged on the outer side of the needle head, a detachable end cover is arranged at the tail end of the needle cylinder, and the sampling piston is completely inserted into the needle cylinder and is in sliding connection with the needle cylinder. A sliding groove penetrating through the needle cylinder is formed in the front end of the needle cylinder, a pulling plate is arranged on the side face of the piston, a through hole opposite to the sliding groove in position is formed in the front end face of the pulling plate, the needle head comprises a puncture part and a fixing part, one end of the connecting hose is fixedly connected with the puncture part, and the other end of the connecting hose is fixedly connected with the fixing part. The thyroid biopsy sampling device has the advantages of being convenient and stable to operate, and solves the problems that in the prior art, thyroid is prone to shaking in the biopsy sampling process, discomfort of a patient is increased, and detection accuracy is affected.

The application relates to the technical field of image analysis, in particular to a needle tip position recognition method for thyroid fine needle puncture ultrasound images, which comprises the following steps: acquiring each frame of target ultrasound image in a current puncture process, and determining a local difference characteristic value corresponding to each pixel point; determining a feature state variation index corresponding to each pixel point; screening a target variation region from each frame of target ultrasound image, and performing edge detection on the target variation region; screening a target fine needle region from each frame of target ultrasound image; determining a fine needle motion state corresponding to each frame of target ultrasound image according to the motion change condition between the target fine needle regions in adjacent frames of target ultrasound image; and recognizing the needle tip position in each frame of target ultrasound image based on the fine needle motion state corresponding to each frame of target ultrasound image. The application realizes the recognition of the needle tip position by analyzing the target ultrasound image, and improves the accuracy of the needle tip position recognition.

The described technology pertains to a sampling device (100) designed for fine-needle aspiration, addressing challenges in obtaining high-quality cytological samples. The device comprises a body (110) configured to hold a disposable syringe (120), a first actuator (130) for sliding the syringe housing (121) along its longitudinal axis (122), and a second actuator (140) for sliding the syringe plunger (123) along the same axis. A control arrangement (160) operates the device in various modes, including loading, idle, ready, sampling, and unloading, by controlling actuator movements within predefined stroke limits. The device facilitates precise sample collection through synchronized or independent actuator motions, creating vacuum conditions and enabling reciprocating movements for tissue extraction. The assembly includes a disposable syringe and needle (150), and the method involves sequential operational modes for sample collection and preparation for analysis. The described technology enhances diagnostic accuracy, reduces operator dependency, and minimizes patient risks.

A biopsy device includes a reusable assembly that includes an outer housing and a plunger lock mechanism located in the outer housing. The plunger lock mechanism includes an actuation member accessible outside the outer housing that moves relative to the outer housing and includes a cam surface. A release flange is configured to move axially in the outer housing and includes a follower surface. A gripping finger is configured to move laterally with axial movement of the release flange. The cam and follower surfaces are configured to cooperate such that movement of the actuation member relative to the outer housing moves the release flange axially relative to the gripping finger. The release flange is configured to move the gripping finger from a locked configuration engaged with a plunger of a syringe to an unlocked configuration disengaged with the plunger of the syringe.

A catheter-based biopsy system integrates real-time optical coherence tomography (OCT) imaging with a multi-degree-of-freedom biopsy needle for precise tissue sampling within luminal organs. The system comprises a segmented handle, an outer sheath, a steerable needle, and an imaging stylet housed within the needle. The imaging stylet includes a metasurface-based optical lens for acquiring cross-sectional images through an imaging window in the needle. Independent handle segments control the extension of the needle and the positioning of the imaging stylet. The system supports multiple operational modes, including imaging, image-guided biopsy, and tissue retrieval, with optional encoder-based tracking for enhanced navigation. The integrated design enables targeted fine needle aspiration and biopsy under direct visualization, improving diagnostic accuracy and procedural efficiency.