Application of mesaconine
A technology of wuningine and myocardial fibrosis, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, drug combinations, etc., can solve the toxic reactions that easily cause more serious acute nephritis and kidney failure, etc. problems, to achieve the effect of clear chemical structure and rich sources of raw materials
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[0058] Example 1 Preparation of Adriamycin-Induced Myocardial Fibrosis Mouse Model, Experimental Grouping and Dosing Scheme
[0059] We selected the classical model of chronic heart failure induced by multiple small doses of doxorubicin to investigate the effect of zhongunine on chronic heart failure induced by myocardial fibers. As shown in Table 1, the C57BL / 6 mice were randomly divided into 6 groups according to body weight balance. Except for normal mice, other mice were intraperitoneally injected (i.p.) adriamycin 3.5mg / kg weekly, repeated for 9 weeks, starting from the 64th day after modeling, given high, medium and low doses of Wuningine and positive Cedilanid (the sample to be tested was dissolved in normal saline, and the administration volume was 10ml / kg) was continuously treated for 57 days, and the experiment ended on the 121st day. The echocardiography detection system was used to evaluate the structure and function of the mouse heart, and the heart was collected....
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