Application of mesaconine

A technology of wuningine and myocardial fibrosis, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, drug combinations, etc., can solve the toxic reactions that easily cause more serious acute nephritis and kidney failure, etc. problems, to achieve the effect of clear chemical structure and rich sources of raw materials

Active Publication Date: 2018-04-17
SICHUAN GOODDOCTOR PHARMA GRP
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Problems solved by technology

However, since aconitine often contains toxic components such as aconitine, improper processing or excessive doses can easily cause more serious toxic reactions such as acute nephritis and kidney failure. It is necessary to search for high-efficiency and low-toxic cardiotonic components in aconite. It has been the research subject of many researchers for many years, and successively isolated and identified N-deethylaconine (N-deethylaconine), mesaconine (mesaconine), hypaconine (hypaconine) from Aconite Beiwutinine (beiwutininine), Fuziling (fuzinine) and other cardiotonic active ingredients, and in isolated bullfrog and rat hearts and in vivo rats, it has been confirmed that beiwutinine has a significant effect on improving heart function, and can Effective prevention and treatment of acute heart failure caused by myocardial ischemia-reperfusion injury, the relevant work has applied for a Chinese patent, and was authorized in 2012 (Wang Fengpeng et al., authorization announcement number CN 102146057B), the patent does not mention anything about the drug Can treat myocardial fibrosis, and myocardial fibrosis often does not occur in acute heart failure caused by myocardial ischemia-reperfusion injury

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Examples

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Embodiment 1

[0058] Example 1 Preparation of Adriamycin-Induced Myocardial Fibrosis Mouse Model, Experimental Grouping and Dosing Scheme

[0059] We selected the classical model of chronic heart failure induced by multiple small doses of doxorubicin to investigate the effect of zhongunine on chronic heart failure induced by myocardial fibers. As shown in Table 1, the C57BL / 6 mice were randomly divided into 6 groups according to body weight balance. Except for normal mice, other mice were intraperitoneally injected (i.p.) adriamycin 3.5mg / kg weekly, repeated for 9 weeks, starting from the 64th day after modeling, given high, medium and low doses of Wuningine and positive Cedilanid (the sample to be tested was dissolved in normal saline, and the administration volume was 10ml / kg) was continuously treated for 57 days, and the experiment ended on the 121st day. The echocardiography detection system was used to evaluate the structure and function of the mouse heart, and the heart was collected....

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Abstract

The invention discloses an application of mesaconine. The application is the application of mesaconine or pharmaceutically acceptable salts, esters or solvates of mesaconine in preparation of drugs orhealth care products for preventing and / or treating myocardial fibrosis. Mesaconine can effectively prevent and / or treat myocardial fibrosis and chronic heart failure or cardiac remodeling caused bymyocardial fibrosis.

Description

technical field [0001] The invention relates to an application of wuningine. Background technique [0002] With the advent of an aging society, the incidence and mortality of heart failure are on the rise. The latest clinical statistics in 2015 show that the prevalence of heart failure patients in China has exceeded 10 million, bringing a heavy economic burden to society. . Chronic heart failure (CHF) is a progressive heart disease. Once started, it can continue to deteriorate even if there is no new myocardial damage. Although some breakthroughs have been made in the treatment of heart failure, its prognosis is poor, and the five-year mortality rate is still as high as 60-80%. This requires us to conduct in-depth research on the molecular pathogenesis of CHF in order to seek more effective therapeutic targets and develop safer and more effective anti-CHF drugs. [0003] Abnormal tissue remodeling is the main cause and pathological basis of organ failure, and fibrosis, as...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/439A61P9/00A61P9/04A23L33/105
Inventor 胡卓伟张晓伟王峰鹏
Owner SICHUAN GOODDOCTOR PHARMA GRP
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