61 results about "Pulmonary Interstitial Fibrosis" patented technology

The invention discloses a cordycepin extract and notoginseng extract and application in prevention and cure pulmonary fibrosis medicine preparation, which is characterized by the following: extracting and condensing from China clothing hairs pore zymocyte powder with water and alcohol; getting cordycepin extract; setting Cordyceps sinensis adenosine, cordycepic acid, and Cordyceps sinensis polysaccharide more than raw bacteria powder about 3-8 double; extracting cordycepin extract from cordycepin crude drug with alcohol; separating large aperture absorption resin; purifying; getting the cordycepin extract; setting the content of cordycepin saponin more than raw cordycepin crude drug for 7-10 double; allocating the cordycepin and cordycepin saponin with mass percent at 90-10% and 10-90%; preparing medicinal compound. This invention possesses very big utility value in clinic.

The invention belongs to the technical field of medicines, and particularly relates to a medicine for treating pulmonary interstitial fibrosis, and a preparation method of the medicine. The medicine for treating pulmonary interstitial fibrosis comprises the following components: astragalus mongholicus, codonopsis pilosula, coastal glehnia root, salvia miltiorrhiza, angelica sinensis, ligusticum wallichii, honeysuckle, fructus forsythiae, scutellaria baicalensis, rhizoma pinelliae preparata, bulbus fritillariae cirrhosae and liquorice. According to the medicine, the astragalus mongholicus and codonopsis pilosula have the effects of tonifying Qi of lung and spleen; the coastal glehnia root has the effect of tonifying Yin of lung and spleen; the salvia miltiorrhiza, angelica sinensis, ligusticum wallichii, honeysuckle, fructus forsythiae, scutellaria baicalensis are used as the supplementary medicines and have the effects of clearing away stasis and resolving phlegm; the rhizoma pinelliae preparata and bulbus fritillariae cirrhosae are respective in moisture state and wet state and are assistant for resolving phlegm; and the liquorice is used for blending other medicines; and all the medicines are blended to realize the effects of supplementing Qi and nourishing Yin, and clearing away stasis and resolving phlegm, and as a result, the Qi can be recovered, the phlegm and stagnant heat can be cleared away, the Qi of the lung and spleen can be tonified by sweat evaporating and turbid descending, the fluid in human body can be smoothly balanced, and the functions can be recovered. The medicine has the functions of supplementing Qi and nourishing Yin, and clearing away stasis and resolving phlegm, and is mainly used for treating breathe hard symptom, weak symptom, dyspnea and tachypnea symptom, coughing symptom and chest pain symptom in clinic.

The invention relates to application of sinomenine as a medicament for preventing and treating pulmonary interstitial fibrosis. The medicament is prepared by sinomenine or pharmaceutically acceptable salt thereof and other adjuvants, wherein sinomenine or pharmaceutically acceptable salt thereof serves as an activating agent. The routes of administration of the medicament include intravenous drip, intramuscular injection, oral administration, transdermal absorption, atomization inhalation and bronchoalveolar lavage. Experiments show that sinomenine does not have obvious difference with the dexamethasone control group in the effect on inhibiting formation of bleomycin-induced pulmonary fibrosis in mice and prove that sinomenine can alleviate pulmonary alveolitis and fibrosis degrees of themice with bleomycin-induced pulmonary fibrosis and the mechanisms are probably realized by inhibiting expressions of TGF (transforming growth factor)-beta1 and alpha-SMA (smooth muscle actin) and thecontent of HYP (hydroxyproline).

The invention discloses a Chinese traditional medicine composition for treating IPF(Idiopathic Pulmonary Fibrosis). The Chinese traditional medicine composition is composed of following ingredients in unit of weight: 10-20 g of radix pseudostellariae, 10-20 g of adenophora tetraphylla, 10-20 g of radix ophiopogonis, 10-20 g of radix scrophulariae, 10-20 g of astragalus membranaceus, 10-20 g of codonopsis pilosula, 10-15 g of rhizoma atractylodis, 10-15 g of rhizoma atractylodis macrocephalae, 10-15 g of the root bark of white mulberry, 10-15 g of scutellaria baicalensis, 10-12 g of peach kernel, 5-10 g of radix platycodi, 10-12 g of fructus aurantii, 10-12 g of radix curcumae, 10-12 g of the root of red-rooted salvia and 5-10 g of radix glycyrrhizae. The Chinese traditional medicine composition provided by the invention has the advantages of simple proportioning and great convenience in use, has the effects of reinforcing Qi and nourishing Yin, promoting blood circulation to remove blood stasis, regulating vital energy and allowing Qi and blood to circulate, and has a remarkable effect on treating IPF.

The invention provides an application of notoginseng saponins Rg 1 in preparing medicine for treating pulmonary interstitial fibrosis. Pharmacological experiments show that if in vitro, the notoginseng saponins Rg 1 can inhibit the activity of human embryonic lung fibroblast and has good dose-dependent; if in vivo, the notoginseng saponins Rg 1 can decrease the lung coefficientand the lung hydroxyproline content of a mouse with pulmonary interstitial fibrosis; the notoginseng saponins Rg 1 can also reduce the pulmonary alveolitis and the degree of pulmonary interstitial fibrosis of the mouse with pulmonary interstitial fibrosis; the raw materials of the notoginseng saponins Rg 1 are easy to obtain, and can be prepared into various common dosage forms such as tablets, capsules, and injections; and the preparation method is simple.

The invention relates to a traditional Chinese medicine granule for treating diffuse interstitial pulmonary fibrosis lung and kidney qi insufficiency syndrome, and can effectively solve the problem of medication in later period treatment of the diffuse interstitial pulmonary fibrosis. In order to solve the problems, the traditional Chinese medicine granule has the technical scheme that ginseng is crushed to obtain ultrafine ginseng powder A; dried orange peel is subjected to water vapor distillation volatile oil extraction; beta-cyclodextrin inclusion compounds B are prepared; the dried orange peel medicine dregs, thunberg fritillary bulb, cortex moutan, epimedium and ginkgo biloba are merged; the mixture is subjected to reflux extraction by 70-percent ethanol to obtain first extract paste; the mixed medicine dregs of the dried orange peel, the thunberg fritillary bulb, the cortex moutan, the epimedium and the ginkgo are decorated and boiled by water to obtain first filter liquid; dwarf lilyturf roots, prepared rehmannia roots, trichosanthes kirilowii Maxim, Chinese pulsatilla roots and coix seeds are decorated and boiled by water to obtain second filter liquid; the first filter liquid and the second filter liquid are merged to obtain second extract paste; the first extract paste and the second extract paste are merged to prepare extract paste fine powder C; ginseng ultrafine powder A, the beta-cyclodextrin inclusion compounds B and the extract paste fine powder C are merged; uniform mixing, pelletization and drying are performed; the traditional Chinese medicine granule is obtained. The traditional Chinese medicine granule has the advantages that the matching is reasonable; the method is scientific; the curative effect is exact and economic; the social benefits are obvious.

The invention relates to application of a polypeptide compound, the polypeptide compound has the characteristics of high enzymolysis stability, high biological activity, no adverse reaction and the like, and the polypeptide compound can improve and treat non-alcoholic liver diseases including fatty liver, cholestatic liver cirrhosis, inflammation, liver injury and fibrosis. And meanwhile, lung diseases accompanied by fibrosis symptoms, such as idiopathic pulmonary interstitial fibrosis, can be improved and treatment.

The invention provides a phlegm reducing traditional Chinese medicine composition. The phlegm reducing traditional medicine composition is prepared from the following raw materials, in parts by weight: 2-12 parts of cortex mori, 1-3 parts of semen brassicae, 1-3 parts of fructus schisandrae, 2-12 parts of fructus perillae, 2-12 parts of semen lepidii, 1-3 parts of rhizoma pinelliae, 2-12 parts ofradix asteris, 1-3 parts of exocarpium citri rubrum and 1-3 parts of radix platycodi. The phlegm reducing traditional Chinese medicine composition achieves the efficacy of phlegm reducing and promoting, reliefs the symptoms of abundant expectoration, coughing, asthma and dyspnea caused by acute and chronic respiratory diseases, further rectifies the phlegm-damp habitus of chronic respiratory diseases, interdicts or delays disease development, and thus achieves the purpose of clinical rehabilitation. The phlegm reducing traditional Chinese medicine composition can be used for treating the diseases such as chronic pharyngitis, chronic bronchitis, bronchial asthma, chronic obstructive pulmonary disease, interstitial pneumonia and pulmonary interstitial fibrosis, has an outstanding curative effect, does not contain chemical synthesis matter, and is suitable for a wide range of groups.

The invention belongs to the technical field of traditional Chinese medicines and in particular relates to traditional Chinese medicine tablets for treating pulmonary interstitial fibrosis and a preparation method thereof. The traditional Chinese medicine tablets are prepared from the following traditional Chinese medicines in parts by weight: 15-20 parts of liquorice, 6-8 parts of rhizoma zingiberis, 10-15 parts of the tuber of stemona, 8-10 parts of semen coicis, 10-15 parts of lily, 6-8 parts of radix ophiopogonis, 15-20 parts of the root bark of white mulberry, 8-10 parts of poria cocos, 15-20 parts of the root of straight ladybell, 10-15 parts of astragalus, 6-8 parts of cortex lycii radicis, 15-20 parts of stephania terandra, 4-6 parts of semen lepidii, 10-15 parts of sticky rice, 8-10 parts of peach kernel, 8-10 parts of polished round-grained rice, 15-20 parts of indigo naturalis, 6-8 parts of clam meal, 4-6 parts of the bulb of fritillary and 15-20 parts of rehmannia glutinosa. The traditional Chinese medicine tablets purely belong to traditional Chinese medicine preparations, the autoimmune activity of lung cells is activated by virtue of herbal treatment, the effects of controlling fibrosis and restoring the respiratory function are achieved, and the preparation method is simple and feasible and easy to popularize and use.

The invention provides a composite of breviscapinum and panax notoginseng saponins Rg1 for treating pulmonary fibrosis, wherein the weight ratio of the breviscapinum to the panax notoginseng saponins Rg1 is 2-5:1-2. The invention also provides application of the composite in the preparation of a medicament for treating the pulmonary fibrosis. The composite of the breviscapinum and the panax notoginseng saponins Rg1 is formulated in a certain proportion and has the advantages of favorable pulmonary fibrosis resistance, remarkable effect and little side effects. Raw materials of the composite are easily obtained and can be prepared in various common dosage forms, such as tablets, capsules, injections and the like, through a conventional method with simple preparation method. The pharmacological action of the composite is obvious; in vitro, the composite can inhibit the activity of human embryonic lung fibroblasts and has favorable dosage dependence; and in vivo, the composite can lower the lung coefficient of a mouse with the pulmonary fibrosis and the content of hydroxyproline of lung tissues and also relieve the alveolitis of the mouse with the pulmonary fibrosis and reduce the degree of the pulmonary fibrosis.

The invention belongs to the technical field of traditional Chinese medicine and particularly relates to a traditional Chinese medicine prescription for treating the pulmonary interstitial fibrosis. The traditional Chinese medicine is prepared from the following traditional Chinese medicine raw materials in parts by weight: 15-20 parts of cordyceps sinensis, 5-10 parts of rhodiola rosea, 5-10 parts of gynostemma pentaphylla, 3-5 parts of wahlenbergia marginata, 3-5 parts of peperomia blanda, 3-8 parts of greenish lily flower, 3-8 parts of ophiopogon root, 3-5 parts of rhizoma panacis majoris, 3-8 parts of radix asteris, 3-5 parts of fritillaria cirrhosa, 3-5 parts of radices primulae, 3-5 parts of walking spleenwort, 1-3 parts of toasted ephedra, 3-5 parts of patrinia, 1-3 parts of dysosma versipellis, 1-3 parts of chrysanthemum morofolium ramat, 3-5 parts of folium agaves america nae, 3-5 parts of erigeron breviscapus, 3-5 parts of rabdosia japonica, 1-3 parts of livistona chinensis, and 1-3 parts of stigma croci. By virtue of the conditioning of the traditional Chinese medicines, the autoimmune activity of the lung cell can be activated, the fibrosis can be controlled and the respiratory function can be recovered; the preparation method is simple and convenient and easy to implement.

An application of the scabrous elephantfoot herb in treating the hepatofibrosis of SARS patient is disclosed.

The present invention discloses one kind of liposome aerosol with protease inhibitor for preventing and treating alveolitis and pulmonary interstitial fibrosis. The liposome aerosol of the present invention is prepared with protease inhibitor, lecithin, cholesterol, vitamin E, ether and other ingredients, and through rotary evaporation, ultrasonic crushing, vibrating stirring, compression atomizing and other steps.