Application of Kudancao in use for resisting lung fibrosis

A technology for pulmonary fibrosis and Bilibilis, which is applied to medical preparations containing active ingredients, medical raw materials derived from angiosperm subphylum, plant raw materials, etc. the effect of

Active Publication Date: 2008-11-12
云南云河药业股份有限公司
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Problems solved by technology

For SARS patients, give full play to the strengths of traditional Chinese medicine, especially the geographical advantages of Yunnan traditional Chinese medicine, and use the traditional Chinese medicine of Esplethys chinensis with a large number of clinical applications to conduct research on the pharmacological effects of anti-pulmonary fibrosis, with the goal of relieving the disease, controlling symptoms and reducing mortality , there is no in-depth research and exploration

Method used

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  • Application of Kudancao in use for resisting lung fibrosis
  • Application of Kudancao in use for resisting lung fibrosis
  • Application of Kudancao in use for resisting lung fibrosis

Examples

Experimental program
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Effect test

Embodiment Construction

[0009] (1) Anti-BLMA of the present invention 5 Induced pulmonary fibrosis in rats

[0010] Bleomycin A 5 (Bleomycin A 5 , BLMA 5 ) induced pulmonary fibrosis animal model of lung histopathology and physiological changes similar to human pulmonary fibrosis. When the number of fibroblasts increases, the production of type I collagen increases significantly, resulting in an imbalance between type I and type III collagen, resulting in collagen deposition and pulmonary fibrosis.

[0011] The experimental, healthy Kunming SD rats with a body weight of 180-200g were randomly divided into normal control group, normal saline group and BLMA group. 5 group and Echinacea group. Among them, BLMA 5 In the group, 20% urethane was injected intraperitoneally with 100mg / 100g of body weight, and under aseptic conditions, the skin in the middle of the neck was cut about 0.5cm long, and a 1ml sterile syringe was inserted into the trachea, and 0.5ml / 100g of body weight was slowly instilled. ...

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Abstract

An application of the scabrous elephantfoot herb in treating the hepatofibrosis of SARS patient is disclosed.

Description

Technical field [0001] The invention belongs to pharmaceutical preparations containing organic active ingredients. Background technique [0002] Severe Acute Respiratory Syndrome, or SARS, is an acute infectious disease with the respiratory tract as the main transmission route, rapid disease progression and high fatality rate. The lung histopathology of dead patients with SARS showed diffuse pulmonary stasis, hemorrhage, alveolar damage, hyaline membrane formation, exfoliation of alveolar cells into the cavity, and fibrinous necrosis of pulmonary small blood vessel walls in different development levels and severities. Inflammatory infiltration of mononuclear cells in the interstitium and lesions such as pulmonary fibrosis (Yan KV, Chan JK. Image in pathology: pulmonary pathology of severe acute respiratory syndrome. Int. J Surg Pathol. 2003; 11: 118-126.). The pathological changes of SARS patients in the late stage of the disease are consistent with the main pathological fe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/74A61K36/27A61K36/19A61K9/20A61K9/12A61P11/00
Inventor 王殿华张旋张恒丽张洁薛凤麟雷伟亚张荣平
Owner 云南云河药业股份有限公司
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