Application of sinomenine or pharmaceutically acceptable salt thereof as medicament for preventing and treating pulmonary interstitial fibrosis

Abstract

The invention relates to application of sinomenine as a medicament for preventing and treating pulmonary interstitial fibrosis. The medicament is prepared by sinomenine or pharmaceutically acceptable salt thereof and other adjuvants, wherein sinomenine or pharmaceutically acceptable salt thereof serves as an activating agent. The routes of administration of the medicament include intravenous drip, intramuscular injection, oral administration, transdermal absorption, atomization inhalation and bronchoalveolar lavage. Experiments show that sinomenine does not have obvious difference with the dexamethasone control group in the effect on inhibiting formation of bleomycin-induced pulmonary fibrosis in mice and prove that sinomenine can alleviate pulmonary alveolitis and fibrosis degrees of themice with bleomycin-induced pulmonary fibrosis and the mechanisms are probably realized by inhibiting expressions of TGF (transforming growth factor)-beta1 and alpha-SMA (smooth muscle actin) and thecontent of HYP (hydroxyproline).

Description

technical field [0001] The present invention relates to an alkaloid used for preventing and treating pulmonary interstitial fibrosis, in particular to sinomenine or its pharmaceutically acceptable salt for preventing and treating pulmonary interstitial fibrosis caused by various chronic inflammatory pathological mechanisms change. Background technique [0002] 1. Pharmacological effects of sinomenine [0003] Sinomenine (sinomenine) is one of the alkaloids extracted from the stem and root of Sinomenium acutum (Thunb.) R.etWils., which is a known medicinal substance. Modern pharmacological studies have shown that sinomenine has a variety of pharmacological effects. In a nutshell, the main pharmacological effects of sinomenine known so far are as follows: anti-inflammatory, immunosuppressive, antihypertensive, central inhibitory, antiarrhythmic, etc. [0004] Sinomenine hydrochloride has the following pharmacological effects: [0005] 1. Anti-inflammatory effect: can inhib...

AI Technical Summary

Problems solved by technology

[0056] (2) Pharmacology and adverse reactions of cyclophosphamide

[0064] (3) Pharmacology and adverse reactions of colchicine

Other clinical and experimental studies on the adverse reactions of sinomenine have not found reports of damage to major organs or tissues caused by long-term use of the drug within the therapeutic dose range, thus contradicting the clinical safety of the drug

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