Application of FTO as target in treatment of pressure-loaded myocardial injury

A technology for myocardial injury and stress, applied in the field of biomedicine, can solve the problems such as the unclear role of FTO, achieve good clinical application prospects, improve cardiac function, and enhance the effect of myocardial contractility

Active Publication Date: 2020-07-31
ZHONGSHAN HOSPITAL FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, the role of FTO in glucose metabolism is still unclear.

Method used

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  • Application of FTO as target in treatment of pressure-loaded myocardial injury
  • Application of FTO as target in treatment of pressure-loaded myocardial injury
  • Application of FTO as target in treatment of pressure-loaded myocardial injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] 1 method

[0035] 1.1 Animals and TAC surgery

[0036] The animals used in this experiment were clean-grade C57BL / 6 mice purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd. Eight-week-old male mice were constructed with pressure-loaded myocardial injury model by transverse aortic constriction (TAC), and the steps were as follows:

[0037] (1) After depilation of the mouse's chest, anesthesia and fixation, the skin was cut along the median incision of the neck to expose the chest to the sternal angle;

[0038] (2) Use ophthalmic scissors to cut the chest along the suprasternal fossa to the sternal angle, and use a chest expander to open the chest wall, and you can see the white fat-like tissue that is the thymus;

[0039] (3) Carefully bluntly separate the thymus tissue with microscopic tweezers, suck out the blood with a sterile cotton swab, and the aortic arch is below the thymus;

[0040] (4) Carefully separate the tissues near the aortic ...

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Abstract

The invention relates to an application of FTO (Fat mass and obesity associated) protein as a target in treatment of pressure-loaded myocardial injury. It is proved that after a heart is stimulated bypressure overload, FTO down-regulation is an important cause of myocardial damage; a mouse with overexpression FTO pressure-loaded myocardial injury is obviously increased in myocardial sugar uptakeand obviously improved in cardiac function compared with those of a mouse in a model group, so that the overexpression FTO can treatment myocardial injury after pressure overload, and FTO is a drug target for treatment of pressure-loaded myocardial injury. The invention further provides an FTO overexpression vector with a remarkable curative effect. The application has the advantages that the application of the FTO as the treatment target for improving the pressure-loaded myocardial injury is developed, and a new drug research direction is provided for the pressure-loaded myocardial injury disease; and the invention provides a myocardial injury drug after pressure overload with FTO as the target, and the drug has a clinical application prospect.

Description

technical field [0001] The present invention relates to the field of biomedical technology, in particular, to the application of FTO as a target in the treatment of pressure-loaded myocardial injury, and the designed FTO overexpression vector and its application in the preparation of clinical drugs for the treatment of pressure-loaded myocardial injury. use. Background technique [0002] Clinically, there are various causes of myocardial injury, and cardiac pressure overload is one of the important causes of myocardial injury and remodeling. Clinically common pressure overload diseases mainly include hypertension, aortic valve stenosis, etc., but combined with the current national conditions and the implementation of effective devices to treat valve abnormalities, hypertension is currently the main primary disease of such diseases. Although the current antihypertensive and anti-myocardial remodeling drugs have made great progress, they still cannot completely reverse myocar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K48/00A61K38/44A61P9/04C12Q1/02C12N15/864C12N15/53
CPCA61K45/00A61K48/005A61K38/44A61P9/04G01N33/5061C12N15/86C12N9/0071C12Y114/11C12N2503/02G01N2500/10C12N2750/14143C12N2800/107
Inventor 葛均波张倍健孙爱军蒋昊董震蔡赟胡琴丰
Owner ZHONGSHAN HOSPITAL FUDAN UNIV
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