Immunoglobulin-like molecules directed against fibronectin-eda

A technology combined with fibronectin, -EDA, used in cardiology and angiogenesis, medical field, can solve problems such as adverse immune system and improper heart healing
CN107406498AInactive Publication Date: 2017-11-28ENCARE BIOTECH BV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ENCARE BIOTECH BV
Publication Date
2017-11-28
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention is concerned with immunoglobulin (Ig)-like molecules or fragments thereof for use in treatment, prevention, or prevention of progression of adverse cardiac remodelling and conditions resulting from or relating to pressure-overload, such as heart failure, aneurysm formation and remote myocardial fibrosis and for use in improving angiogenesis, preferably after ischemic injury. The invention also provides nucleic acid molecules encoding said Ig-like molecules, vectors comprising same, and host cells comprising same.
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Description

technical field

[0001] The invention relates to the field of medicine, and in particular the fields of cardiology and angiogenesis. The invention provides immunoglobulin (Ig)-like molecules, such as antibodies, and antigen-binding fragments thereof that specifically bind the EDA-domain of fibronectin-EDA. These Ig-like molecules are particularly suitable for the treatment, prevention or development of adverse cardiac or vascular remodeling and complications associated with myocardial infarction and amelioration or stimulation of angiogenesis. The invention also relates to the treatment of conditions associated with excessive pressure overload. The present invention also relates to pharmaceutical compositions comprising Ig-like molecules, such as antibodies or antigen-binding fragments thereof, and the use of Ig-like molecules, such as antibodies or antigen-binding fragments thereof, for the treatment, prevention of myocardial infarction-related complications and adverse cardi...

Claims

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