Immunoglobulin-like molecules directed against fibronectin-eda
A technology combined with fibronectin, -EDA, used in cardiology and angiogenesis, medical field, can solve problems such as adverse immune system and improper heart healing
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[0084] Immunoglobulin-like molecules, antibodies and antigen-binding fragments thereof
[0085] In a first aspect, the present invention relates to an isolated Ig-like molecule or an antigen-binding fragment thereof that specifically binds to the amino acid sequence GIXXXF (SEQ ID NO: 1) or the amino acid sequence LFPAP (SEQ ID NO: 28), wherein X can be any amino acid.
[0086] The term "isolated" as used herein refers to a material that is substantially or substantially free from components with which it normally accompanies in nature.
[0087] The term "immunoglobulin" (abbreviated "Ig") as used herein is well known in the art and is equivalent to the term "antibody". The term "Ig-like molecule" as used herein refers to any polypeptide comprising an antigen binding site with at least one complementarity determining region (CDR). The term includes, but is not limited to, polyclonal antibodies, monoclonal antibodies, monospecific antibodies, multispecific antibodies, humani...
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