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Use of lipoic acid in preparation of pharmaceutical composition for treatment on pressure-loaded myocardial injury

A technology for myocardial injury and lipoic acid, which is applied in the field of medicine, can solve the problems of unreported lipoic acid, many medicinal materials, and inconvenient use, and achieve the effects of protecting myocardial injury, improving energy metabolism, and inhibiting oxidative stress

Active Publication Date: 2018-09-25
JIANGSU WANHE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to the recognition mechanism of hyperglycemia, the drug of this invention strictly selects the raw material components, so as to achieve the purpose of comprehensive rehabilitation, but this method uses more medicinal materials and is inconvenient to use
However, there is no report about the application of lipoic acid of the present invention in the preparation of pharmaceutical compositions for the treatment of pressure-loaded myocardial injury

Method used

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  • Use of lipoic acid in preparation of pharmaceutical composition for treatment on pressure-loaded myocardial injury
  • Use of lipoic acid in preparation of pharmaceutical composition for treatment on pressure-loaded myocardial injury
  • Use of lipoic acid in preparation of pharmaceutical composition for treatment on pressure-loaded myocardial injury

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] The preparation of embodiment 1 capsule (one)

[0037] The preparation method of lipoic acid capsules is as follows:

[0038] Lipoic acid was purchased from Jiangsu Wanchuan Medical and Health Industry Group Co., Ltd.

[0039] (1) get 100g lipoic acid, micronize, cross 200 mesh sieves, get lipoic acid fine powder;

[0040] (2) Put 50g of Poloxamer 237 in a suitable container, put it in a water bath at 49°C-50°C and heat it to a molten liquid state, add 100g of lipoic acid fine powder, and stir quickly and fully at 49°C-50°C until the mixture is uniform , stand still to remove air bubbles, spread the mixture into a thin layer and put it in a -5°C refrigerator for rapid cooling. After the mixture is completely solidified, take it out and pulverize it, and dry it in a vacuum dryer at 35°C for 24 hours, and pulverize it through a 100-mesh sieve to obtain sulfur Caprylic Acid Solid Dispersion.

[0041](3) Add 82g of microcrystalline cellulose, 10g of lactose, 8g of sodium...

Embodiment 2

[0042] The preparation of embodiment 2 intravenous injections (two)

[0043] The preparation method of lipoic acid intravenous injection is as follows:

[0044] Lipoic acid was purchased from Jiangsu Wanchuan Medical and Health Industry Group Co., Ltd.

[0045] (1) Place co-solvent ethylenediamine in water for injection cooled to room temperature, and mix well;

[0046] (2) Measure lipoic acid and co-solvent ethylenediamine according to the mass ratio of lipoic acid and co-solvent ethylenediamine as 1:0.23, place lipoic acid in co-solvent ethylenediamine solution, and stir until completely dissolved;

[0047] (3) Weigh hydroxypropyl-β-cyclodextrin according to the mass ratio of lipoic acid to hydroxypropyl-β-cyclodextrin as 1:2.5, and add hydroxypropyl-β-cyclodextrin to step (2) In the prepared solution, stir until completely dissolved;

[0048] (4) Add water for injection to the full amount;

[0049] (5) potting the medicinal solution in a brown ampoule;

[0050] (6) Ste...

Embodiment 3

[0051] Embodiment 3 animal experiments

[0052] 1. Experimental method

[0053] 1. Preparation of experimental animals and animal models

[0054] The mouse model preparation method of operation group (TAC group): SPF grade male C57BL / 6 mice (purchased from Shanghai Jiesijie Experimental Animal Co., Ltd.), aged 8-10 weeks, weighing 20-25g, were selected for tracheal intubation. Put the mouse in an anesthesia airtight box, and after the muscle strength disappears, quickly lie supine and fix it on the operation board; aim the cold light source at the neck of the mouse, and gently pull out the tongue of the mouse with tweezers , under the irradiation of a cold light source, you can see a tracheal opening with a strong refraction that is consistent with the respiratory rate. Quickly insert the endotracheal tube into the airway. Connect to the anesthesia ventilator. If the intubation is successful, you can see that the mouse’s chest cavity rises and falls with the frequency of the...

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Abstract

The invention relates to a clinical use of lipoic acid in treatment on pressure-loaded myocardial injury. Lipoic acid is applied to a patient suffering from pressure-loaded myocardial injury based onthe standard treatment so that the activity of the myocardial mitochondrial aldehyde dehydrogenase 2 (ALDH2) is improved, the myocardial mitochondrial energy metabolism is improved, the oxidative stress is inhibited, the cardioprotective effect is produced and the occurrence and development of myocardial injury is delayed. Lipoic acid can improve myocardial mitochondrial energy metabolism throughrecovering the activity of ALDH2 in the myocardial mitochondria, inhibit oxidative stress, prevent the myocardial injury after pressure overload and improve the quality of life of patients. The use provides a novel use for lipoic acid so that the lipoic acid can be well used. The use provides a novel drug research direction for pressure-loaded myocardial injury diseases and has a good applicationprospect.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of lipoic acid in the preparation of a pharmaceutical composition for treating pressure-loaded myocardial injury. Background technique [0002] Cardiac pressure overload caused by various reasons is one of the common causes of myocardial injury and remodeling. Clinically common pressure overload diseases mainly include hypertension, aortic valve stenosis, etc., but combined with the current national conditions and the implementation of effective devices to treat valve abnormalities, hypertension is currently the main primary lesion of such diseases. Although the current antihypertensive and anti-myocardial remodeling drugs have made great progress, they still cannot completely reverse myocardial injury and remodeling, and eventually lead to severe myocardial injury. It is urgent to discover the therapeutic effect of myocardial injury from a new perspective new t...

Claims

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Application Information

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IPC IPC(8): A61K31/385A61P9/00
CPCA61K31/385A61P9/00
Inventor 葛均波孙爱军李文佳吴剑孙晓垒王鹏
Owner JIANGSU WANHE PHARMA
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