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Application of 3-hydroxyphenylacetic acid (3-HPA) in preparation of drug for improving ventricular pathological reconstruction and/heart failure after myocardial infarction

A hydroxyphenylacetic acid and heart failure technology, applied in the field of biomedicine, can solve the problem of heart failure burdening the medical security system, etc., and achieve the effects of inhibiting ventricular pathological remodeling, inhibiting myocardial hypertrophy, and improving heart failure.

Active Publication Date: 2020-08-11
SHANGHAI UNIV
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  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

With the development of percutaneous coronary intervention (PCI) reperfusion and other treatment methods, the mortality rate in the acute phase of myocardial infarction has been greatly reduced. brought a huge burden

Method used

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  • Application of 3-hydroxyphenylacetic acid (3-HPA) in preparation of drug for improving ventricular pathological reconstruction and/heart failure after myocardial infarction
  • Application of 3-hydroxyphenylacetic acid (3-HPA) in preparation of drug for improving ventricular pathological reconstruction and/heart failure after myocardial infarction
  • Application of 3-hydroxyphenylacetic acid (3-HPA) in preparation of drug for improving ventricular pathological reconstruction and/heart failure after myocardial infarction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] 1. Establishment of myocardial infarction model in mice

[0028] 1) Inject the mice intraperitoneally with 4% chloral hydrate (0.01ml / g), and wait for the anesthesia to exert its effect (clamp the tail and limbs of the mouse with tweezers, and when the tail and limbs of the mouse have no reflex response, confirm that the anesthesia has been fully anesthetized.

[0029] 2) Place the fully anesthetized mouse on a constant temperature pad with a temperature of 37°C, depilate its neck and chest, expose the neck of the mouse, disinfect it with 75% alcohol, and separate it along a straight line under the microscope to cover the trachea When the trachea is exposed, a small hole is cut between the two tracheal cartilage rings under the glottis, and a tracheal tube is inserted and fixed.

[0030] 3) Check the movement of the thorax to ensure that both lungs are well ventilated (respiratory rate is 120 breaths / min). Then, under a microscope, use small scissors to make a transvers...

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Abstract

The invention provides application of 3-hydroxyphenylacetic acid (3-HPA) in preparation of a drug for improving ventricular pathological reconstruction and / heart failure after myocardial infarction, and belongs to the technical field of biomedicine. The 3-HPA can improve cardiac functions after myocardial infarction, reduce heart fibrosis after myocardial infarction and improve the size of cardiacmuscle cells after myocardial infarction. Mouse animal model experiments show that the 3-HPA can improve cardiac functions of mice after rejection of intestinal florae from myocardial infarction miceby antibiotic treatment, reduce heart fibrosis after rejection of intestinal florae from myocardial infarction mice by antibiotic treatment and inhibit myocardial hypertrophy after rejection of intestinal florae from myocardial infarction mice by antibiotic treatment.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to the application of 3-hydroxyphenylacetic acid in the preparation of medicines for improving pathological remodeling of ventricles and / or heart failure after myocardial infarction. Background technique [0002] Myocardial infarction is a major disease that seriously endangers human health. With the development of percutaneous coronary intervention (PCI) reperfusion and other treatment methods, the mortality rate in the acute phase of myocardial infarction has been greatly reduced. brought a huge burden. Therefore, it is of great significance to explore new methods for the treatment of pathological ventricular remodeling and heart failure after myocardial infarction. Contents of the invention [0003] The object of the present invention is to provide the application of 3-hydroxyphenylacetic acid in the preparation of medicines for improving pathological ventricular remodeli...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/192A61P9/10A61P9/04A61P9/12
CPCA61K31/192A61P9/04A61P9/10A61P9/12
Inventor 肖俊杰贝毅桦冯静宜时超赵程琳
Owner SHANGHAI UNIV
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