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Uncaria extract and application thereof in preparing medicines for reducing blood fat and resisting cardiac hypertrophy

An extract and application technology, applied in the field of Uncaria chinensis extract and its new application in the preparation of blood lipid-lowering and anti-myocardial hypertrophy drugs, can solve problems such as no myocardial hypertrophy, and achieve prevention and treatment of hypertensive heart disease and cardiac hypertrophy. Functional failure, reducing the probability of myocardial damage, and preventing and treating cardiomyopathy

Inactive Publication Date: 2010-08-04
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The prior art discloses that Uncaria has antihypertensive effect, but there is no literature report about Uncaria or its extracts can reduce triglyceride or inhibit cardiac hypertrophy

Method used

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  • Uncaria extract and application thereof in preparing medicines for reducing blood fat and resisting cardiac hypertrophy
  • Uncaria extract and application thereof in preparing medicines for reducing blood fat and resisting cardiac hypertrophy
  • Uncaria extract and application thereof in preparing medicines for reducing blood fat and resisting cardiac hypertrophy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1 prepares Uncaria extract

[0031] 1) Take 10 kg of genuine Uncaria, add 80% ethanol after crushing, heat and extract 5 times, filter, and combine the filtrate. , dry hooked stems of Uncaria chinensis or Uncaria unsessile;

[0032] 2) Concentrate the filtrate under reduced pressure into a thick extract, add 0.5% hydrochloric acid to dissolve, wash, and collect the filtrate;

[0033] 3) The filtrate is extracted with chloroform, and the filtrate is adjusted to pH 8 with an alkaline solution, and the chloroform solution is combined after several times;

[0034] 4) Concentrate the chloroform solution under reduced pressure to obtain the Uncaria extract.

Embodiment 2

[0035] Embodiment 2, the pharmacological action experiment of Uncaria extract

[0036] (1) Uncaria extract reduces blood triglyceride level in SHR rats

[0037] experimental method

[0038] Uncaria extract (code name: KHR) is mixed with vegetable oil to make suspension.

[0039] Twelve five-week-old inbred WKY rats were used as the normotensive control group, and 36 five-week-old inbred SHR rats were randomly divided into three groups, with 12 rats in each group. month:

[0040] 1. WKY control group: WKY rats were given vegetable oil once a day by intragastric administration (1 ml per kg body weight per day).

[0041] 2. SHR control group: SHR rats were given vegetable oil by gavage once a day (1 ml per kg body weight per day).

[0042] 3. KHR 100 group: SHR rats were given Uncaria extract vegetable oil suspension once a day by intragastric administration (1 ml per kg body weight per day, containing 100 mg of Uncaria extract).

[0043] 4. KHR 250 group: SHR rats were give...

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Abstract

The invention belongs to the field of traditional Chinese medicines and relates to an uncaria extract and new application thereof in preparing medicines for reducing blood fat and resisting cardiac hypertrophy. Proved by the animal experiment, the uncaria ethanol extract has the functions of reducing blood fat and resisting cardiac hypertrophy, and especially can reduce the triglyceride level in blood, the weight ratio of the left ventricle to the whole heart, and the weight ratio of the left ventricle to the right ventricle. The uncaria ethanol extract can be used as the raw material for pharmaceutical preparations to further prepare the medicines for reducing blood fat and resisting cardiac hypertrophy, so that the medicines can be used for treating disturbance of lipid metabolism and metabolic syndromes, and preventing and curing atherosclerosis, and hypertensive cardiopathy caused by hypertension and cardiac hypertrophy, including myocardial ischemia, myocardial damage, myocardial infarction and heart failure.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and relates to the extract of the traditional Chinese medicine Uncaria uncaria and its new medicine application, in particular to the Uncaria uncaria extract and its new application in the preparation of blood lipid-lowering and anti-cardiac hypertrophy drugs. Background technique [0002] The prior art discloses that hyperlipidemia can lead to diseases such as coronary atherosclerosis and metabolic syndrome, and eventually lead to vascular lesions in important organs such as the heart, brain, and kidneys, including pathological changes such as lumen stenosis, plaque rupture, and thrombosis Changes, and then lead to myocardial infarction, cerebral embolism, glomerulosclerosis, renal failure and other serious diseases and life-threatening. Studies have found that the initial cause of the above serious consequences is abnormal lipid metabolism characterized by hyperlipidemia, especially...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/74A61P3/00A61P3/06A61P9/00A61P9/04A61P9/10A61P9/12A61K135/00
Inventor 朱依纯朱依谆陈莹
Owner FUDAN UNIV
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