Supermicro Tongxinluo Chinese herbal composite and its new usage

A composition, Tongxinluo technology, applied in the field of ultra-fine Tongxinluo traditional Chinese medicine composition, can solve the problems of inability to destroy cell structure, immature extraction and refining methods, uneven mixing, etc., and achieve improvement of blood lipids and vascular lumen stenosis , reduce the reflow area and infarct size, and reduce the effect of AngII level

Active Publication Date: 2007-05-02
HEBEI YILING MEDICINE INST
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to many difficulties in the development and application of insect medicines, such as the incomplete clarity of most active ingredients, immature extraction and refining methods, and lack of reference substances, they all use the traditional direct pulverization method to make medicinal powders in the production process.
However, the traditional pulverization process exists: 1) it cannot destroy the cell structure, and it needs to pass through the cell membrane to affect the release and dissolution of active ingredients in medicinal materials; The stability of active ingredients has a negative impact; 3) The difficulty of crushing different parts of insect medicinal materials is different, and uneven mixing is caused by particle differences, which affects the uniformity of product quality and other issues
These problems also directly affect the stability of the active ingredients of the drug and the absorption of the human body, thereby reducing the efficacy of the drug.

Method used

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  • Supermicro Tongxinluo Chinese herbal composite and its new usage
  • Supermicro Tongxinluo Chinese herbal composite and its new usage
  • Supermicro Tongxinluo Chinese herbal composite and its new usage

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0023] Embodiment Pharmacological experiment 1

[0024] Effect of Tongxinluo Superfine Powder on Endothelial Function Damage of Atherosclerosis

[0025] The purpose of the experiment To observe the effect of Tongxinluo superfine powder treatment on the changes of vascular endothelial function in atherosclerosis (AS), so as to evaluate the therapeutic effect of Tongxinluo superfine powder on AS.

[0026] Preparation and grouping of animal models 56 healthy male New Zealand white rabbits (body weight 2.5-3.0Kg) were randomly divided into two groups: normal diet group (fed with common feed, 6), and high-fat diet group (fed with high-cholesterol and high-fat feed, 5), after 8 weeks high-fat diet to form atherosclerosis model, and then they were randomly divided into 6 groups: continue high-fat diet group (10), ordinary Tongxinluo group 0.5g / kg, superfine powder Tongxin Network group (1, 0.5, 0.2g / kg), fed for 12 weeks.

[0027] Indicator detection

[0028] Deter...

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PUM

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Abstract

An application of the Chinese medicine 'Superfine Tongxinluo' in relaxing the vascular endothelial injury caused by atherosclerosis, decreasing the cardiac infarction range after AMI reperfusion, preventing hyperlipemia and atherosclerosis, and treating arteria coronaria spasm, pile, thromboangiitis obliterans, platelet coagulation, etc is disclosed.

Description

technical field [0001] The invention relates to a superfine Tongxinluo traditional Chinese medicine composition and several new uses thereof, belonging to the field of traditional Chinese medicine. Background technique [0002] Coronary arteriosclerotic heart disease refers to the formation of plaque on the coronary artery wall, resulting in stenosis or blockage of the vessel lumen, causing myocardial ischemia, hypoxia, and coronary artery spasm, which are classified into the category of ischemic heart disease. [0003] Tongxinluo Capsule is a three-class Chinese patent medicine developed and invented by Professor Wu Yiling and has obtained a patent (ZL01131203.3) for treating cardiovascular and cerebrovascular diseases. Professor Wu Yiling pioneered the use of TCM collateral disease theory to explore the pathogenesis of coronary heart disease, and applied five insect medicines, including scorpion, centipede, earth element, leech and cicada slough, to the treatment of corona...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/64A61K36/725A61K9/14A61P9/10A61P9/14A61P7/02A61P3/06A61K35/62A61K35/646A61K35/648
Inventor 吴以岭耿永健
Owner HEBEI YILING MEDICINE INST
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