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A kind of separation method and application of licorice chalcone b

A technology of licorice chalcone and medicine, which is applied in the field of medicine, can solve problems such as no cardiovascular disease research reports, and achieve the effect of simple and efficient separation method, inhibition of hypertrophy, controllability and good repeatability

Active Publication Date: 2021-01-26
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is no relevant research report on the treatment of cardiovascular diseases with licochalcone B in the prior art

Method used

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  • A kind of separation method and application of licorice chalcone b
  • A kind of separation method and application of licorice chalcone b

Examples

Experimental program
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Effect test

Embodiment 1

[0040]Example 1: Separation of Licorice Chalcone B

[0041]The crushed licorice was refluxed and extracted twice with water for 1 hour each time. The dregs were filtered off, the filtrate was combined and concentrated to obtain an extraction concentrate; the extraction concentrate was suspended in water and passed through the macroporous adsorption resin column at a flow rate of 2BV / h ; Wash with 4BV water at a flow rate of 2BV / h; Wash with 5BV 20% (volume fraction) ethanol at a flow rate of 2BV / h; Wash with 4BV 40% ethanol at a flow rate of 2BV / h; Use 95% of 4BV Ethanol was flushed at a flow rate of 2BV / h; the 40% ethanol eluate was collected and concentrated and dried, and then preparative liquid chromatography was used to separate and collect the chromatographic peak for 52 minutes, and the solvent was recovered under reduced pressure to obtain licorice chalcone B with a purity greater than 95%.

[0042]Among them, the preparative liquid chromatography separation conditions are:

[0043]I...

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Abstract

The invention provides an application of licochalcone B as an angiotensin-converting enzyme inhibitor. Licochalcone B has extremely strong angiotensin-converting enzyme inhibitory activity, and the inhibition rate of angiotensin-converting enzyme is as high as 95%. It can be used to prevent and / or treat cardiovascular diseases, type 2 diabetes and diabetic nephropathy and other diseases that need to inhibit the activity of angiotensin converting enzyme. The invention also provides a separation method of licochalcone B, which is very simple and efficient, easy to operate, controllable and repeatable, and the separated licochalcone B has high purity.

Description

Technical field[0001]The invention belongs to the technical field of medicine, and specifically relates to a method for separating licorice chalcone B and its application in preparing angiotensin converting enzyme inhibitors.Background technique[0002]Licorice is a leguminous perennial herb. It is a commonly used and indispensable Chinese medicinal material in clinical practice. Because it can harmonize hundreds of medicines and cure hundreds of toxins, it is known as "the old man". Licorice was first published in "Shen Nong's Materia Medica". It was called Meicao and Migan. It was listed as the top grade. It is believed that it mainly contains cold and heat evils, strong muscles and bones, long muscles, power, golden sores, and detoxification. Licorice is mainly used to treat inflammation, cardiovascular and cerebrovascular diseases, oxidative aging, tumors, etc., which are inseparable from the pharmacological effects of the active ingredients of licorice extract.[0003]The main acti...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/12A61P3/10A61P9/04A61P9/12A61P13/12A61P27/02C07C45/78C07C45/79C07C49/84
CPCA61K31/12A61P3/10A61P9/04A61P9/12A61P13/12A61P27/02C07C45/78C07C45/79C07C49/84
Inventor 王毅杨振中赵筱萍
Owner ZHEJIANG UNIV
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