Applications of drynaria fortune and drynaria fortune extract in prevention or treatment of heart failure

A kind of Rhizoma Drynariae extract, the technology of Rhizoma Drynariae, applied in the field of Rhizoma Drynariae and its extract, preventing or treating heart failure

Inactive Publication Date: 2015-12-30
BEIJING QIHUANG PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, there are few reports on the application of drynaria in other aspects.

Method used

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  • Applications of drynaria fortune and drynaria fortune extract in prevention or treatment of heart failure
  • Applications of drynaria fortune and drynaria fortune extract in prevention or treatment of heart failure
  • Applications of drynaria fortune and drynaria fortune extract in prevention or treatment of heart failure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0104] The preparation method of the drynaria extract of the present invention can refer to the method in Example 1 of CN1484529A, and the typical preparation method of the drynaria extract includes the following steps:

[0105] 〔Crushing medicinal materials→〕water / alcohol decoction→resin adsorption→(water washing→)alcohol / water elution→post-treatment.

[0106] In the above method, the pulverization of medicinal materials is a routine step well known to those skilled in the art. As for the pulverization method, the present invention is not limited. If the particle size of the pulverized powder is too coarse, it is difficult to fully extract the active ingredient; if the powder is too fine, it will bring disadvantages to the step of separating the extract after decoction. For this, those skilled in the art can choose according to actual experience. , there is no restriction on this.

[0107] In order to extract the active ingredients, water and / or alcohol immersion extraction...

specific Embodiment approach

[0126] Embodiments of the present invention will be described in detail below in conjunction with examples, but those skilled in the art will understand that the following examples are only used to illustrate the present invention, and should not be considered as limiting the scope of the present invention. Those who do not indicate the specific conditions in the examples are carried out according to the conventional conditions or the conditions suggested by the manufacturer. The reagents or instruments used were not indicated by the manufacturer, and they were all commercially available conventional products.

[0127] Example 1

[0128] Weigh 100 grams of Rhizoma Rhizoma Rhizoma Drynariae, crush it into a coarse powder, boil it with 1500ml of water for 1 hour, release the medicinal solution, add 1000ml of water to the residue and boil it, and release the medicinal solution. The two medicinal liquids are combined, filtered, and the medicinal liquid flows through an adsorption...

Embodiment 2

[0130] Except that the reflux solvent and the elution solvent all adopt 70% ethanol solution, operate according to the method of Example 1 to obtain 1.69 grams of extract, with a total flavonoid content of 53.12%, and the HPLC method determines that the naringin content is 32.5% (accounting for 61.2% of the total flavonoids) ).

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PUM

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Abstract

The invention provides applications of drynaria fortune and drynaria fortune extract in prevention or treatment of heart failure. The drynaria fortune and the drynaria fortune extract can effectively reduce the heart weight index of a rat with heart failure, reduce levels of BNP (B-type natriuretic peptide), Ang II (Angiotensin II) and ALD (aldosterone) and remarkably improve the left ventricular systolic function of the rat with heart failure, thereby having the function of preventing or treating heart failure and having positive significance for development and utilization of Chinese herbal medicines, and a new scheme is provided for the treatment of the disease.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to the application of drynaria drynaria and its extract for preventing or treating heart failure. Background technique [0002] Rhizoma Drynaria, aliased as Yajiang, Yanlian Jiang, Climbing Rock Ginger, Minced Meat, Drynaria, Flying Squirrel, Niufeilong, Feilaifeng, Moth Grass, English name Drynariafortunei, belongs to the order True Ferns, Drynaria The family fern is the rhizome of the water keel family plant Quercus fern or Chinese oak fern (Qinling oak fern). [0003] Rhizoma drynariae extract has the functions of nourishing kidney and strengthening bones, relieving injuries and relieving pain, promoting blood circulation, etc. [0004] However, there are few reports on the application of drynaria in other aspects. Contents of the invention [0005] One object of the present invention is to provide the use of drynariae, drynaria extract or composition containing dr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/126A61P9/04
Inventor 谢凤瑛
Owner BEIJING QIHUANG PHARM CO LTD
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