Medicine for preventing and treating coronary heart disease and preparation method and application thereof

A technology for coronary heart disease and drugs, which is applied in the field of drugs for the prevention and treatment of coronary heart disease and its preparation, can solve the problems of patients with abdominal distension, fatigue, hypofunction of the heart, and large gastrointestinal irritation, and achieve clear ingredients, clear mechanism of action, and promote myocardial The effect of cell regeneration

Inactive Publication Date: 2017-05-31
GUANGZHOU XIANGXUE PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, the oral Chinese medicine preparations for the treatment of coronary heart disease in the market are mainly Danshen preparations, such as Danshen Tablets (Danshen, Sanqi, Jiangxiang Oil), Danshen Tablets (Danshen), Shuangdan Oral Liquid (Danshen, Moutan Cortex), Danshen Seven Tablets (Danshen, Sanqi), Compound Danshen Tablets (Danshen, Sanqi, Borneol), Compound Danshen Dripping Pills (Danshen, Sanqi, Borneol), etc., all have blood circulation as their main function. medicine of guiding ideology
And some of the above-mentioned medicines contain borneol, borneol has the characteristics of fragrance and wandering, consumes qi and hurts yang, and long-term use can easily cause cardiac dysfunction, and at the same time it is also more irritating to the gastrointestinal tract. Coronary heart disease has both gastritis, gastroduodenal Patients with ulcers, esophagitis, or patients with deficiency and cold constitution are not suitable for use
At the same time, taking Compound Danshen Tablets for a long time will lead to potassium deficiency symptoms such as abdominal distension and fatigue.

Method used

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  • Medicine for preventing and treating coronary heart disease and preparation method and application thereof
  • Medicine for preventing and treating coronary heart disease and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Step 1, preparation of extract: take Araliaceae plant ginseng (Panax ginseng C.A.Mey) dry root and rhizome 14kg, get Labiatae plant salvia miltiorrhiza (Salvia miltiorrhiza Bge.) dry root and rhizome 6kg, cut into thick Tablets were soaked in 200L of water for 2 hours, then refluxed three times for 2 hours each time, adding 160L of water each time, and the extracts were filtered and combined to obtain the extracts.

[0031] Step 2. Preparation of extract: put the above extract in a single-effect or double-effect decompression concentrator, concentrate under reduced pressure to a relative density of 1.10-1.20 (60°C), then dry under reduced pressure at 60°C, crush Powder, that is, extracts of ginseng and salvia miltiorrhiza.

[0032] Step 3, take ginseng and salvia miltiorrhiza extracts, crospovidone and microcrystalline cellulose, grind them through a 100-mesh sieve, and mix them evenly.

[0033] Step 4. Take the above-mentioned mixed powder, add 80% ethanol to make a s...

Embodiment 2

[0037]Step 1, preparation of extract: take Araliaceae plant ginseng (Panax ginseng C.A.Mey) dry root and rhizome 14kg, get Labiatae plant salvia miltiorrhiza (Salvia miltiorrhiza Bge.) dry root and rhizome 6kg, cut into thick Tablets, add 200L of water, set ultrasonic parameters, ultrasonic frequency is 40kHz, ultrasonic power is 1000W, ultrasonic extraction is three times, each time 2 hours, add water 160L each time, the extracts are filtered separately, combined to obtain extracts.

[0038] Step 2. Preparation of extract: put the above extract in a single-effect or double-effect decompression concentrator, concentrate under reduced pressure to a relative density of 1.10-1.20 (60°C), then dry under reduced pressure at 60°C, crush Powder, that is, extracts of ginseng and salvia miltiorrhiza.

[0039] Step 3, take ginseng and salvia miltiorrhiza extracts, crospovidone and microcrystalline cellulose, grind them through a 100-mesh sieve, and mix them evenly.

[0040] Step 4. Tak...

Embodiment 3

[0044] Step 1, preparation of extract: take Araliaceae plant ginseng (Panax ginseng C.A.Mey) dry root and rhizome 70kg, get Labiatae plant Salvia miltiorrhiza (Salvia miltiorrhiza Bge.) dry root and rhizome 30kg, cut into thick The flakes were subjected to tank group dynamic countercurrent extraction, fed in 4 tanks, 25 kg per tank, and extracted 3 times with water, each time for 2 hours. The second extract from the first tank is released at the specified time, then added to the second tank for the first extraction, the second extract in the second tank is added to water or a certain concentration of ethanol to extract the material, and then added to the third tank for the second extraction 1 extraction, which is recycled in sequence until all 4 cans are extracted, and all the extracts are filtered and combined.

[0045] Step 2. Preparation of extract: put the above extract in a single-effect or double-effect decompression concentrator, concentrate under reduced pressure to a ...

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Abstract

The invention discloses a medicine for preventing and treating coronary heart disease and a preparation method and application thereof. The medicine is extract of ginseng and root of red-rooted salvia, the extract mainly comprises ginsenoside, saccharide, salvianolic acid, amino acid and protein ingredient, and the medicine can be prepared into tablets, capsules, granules, pills and inhalants. The medicine is especially suitable for application in treating coronary heart disease due to qi deficiency and blood stasis or coronary heart disease combined with lower cardiac function and can obviously improve lower cardiac function symptoms caused by the coronary heart disease; syndrome differentiation and treatment rules in theories of traditional Chinese medicine are adopted, nature of symptoms of the coronary heart disease is analyzed deeply, defects that medicine on the current market has are avoided, a novel treatment option is provided for the coronary heart disease, especially that combined with lower cardiac function, and market space is made up well.

Description

technical field [0001] The present invention relates to the field of biomedicine, in particular to a medicine for preventing and treating coronary heart disease and its preparation method and application. Background technique [0002] Coronary heart disease is known as "the first killer of human beings". According to the data released by the National Center for Health Statistics in the United States, heart disease accounts for 35% of the total cause of death, of which coronary heart disease accounts for 24.1%, ranking first among the top 10 causes of death. According to the statistics of the World Health Organization, about 17 million people die from coronary heart disease every year in the world, accounting for more than 50% of the total number of deaths from diseases. There are as many as 60 million patients with coronary heart disease in my country. With the continuous improvement of material living standards, the incidence of coronary heart disease is increasing. After ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61P9/10A61P9/00
CPCA61K36/258A61K36/537A61K2236/331A61K2236/333A61K2300/00
Inventor 付建武曾仑连林生周劲松李志峰
Owner GUANGZHOU XIANGXUE PHARMA CO LTD
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