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Application of traditional Chinese medicine composition in preparation of drug for treating transient ischemic attack

A composition and technology of traditional Chinese medicine, applied in the field of traditional Chinese medicine composition, can solve problems such as adverse reactions and side effects, high price, and limited administration methods

Active Publication Date: 2015-08-12
HEBEI YILING MEDICINE INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The intervention and treatment of cerebrovascular diseases by drugs has become an important topic concerned by the society and the medical field. Although the development of drugs for the treatment of cerebrovascular diseases is still in-depth, the existing drugs are expensive and have limited administration methods. There are many reactions and side effects and it is not suitable for repeated application under normal conditions, or the application is limited due to long medication time and large dosage. At present, there is a lack of a drug that is specifically used to prevent and treat TIA. Therefore, further research and development of high-efficiency, low-efficiency Drugs for the prevention and treatment of cerebral ischemic diseases

Method used

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  • Application of traditional Chinese medicine composition in preparation of drug for treating transient ischemic attack

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] Embodiment 1: the preparation of pharmaceutical capsule of the present invention

[0062] prescription:

[0063] Astragalus 425 g, Aconite 89.5 g, Ginseng 190 g, Salvia miltiorrhiza 220 g, Tinglizi 125 g, Xiangjia bark 170 g, Alisma 200 g, Polygonatum 65 g, Guizhi 85 g, Safflower 85 g,

[0064] Chenpi 70 g

[0065] Preparation:

[0066] (1) Astragalus, Tinglizi, Alisma, ginseng, and Xiangjiapi were refluxed and extracted twice according to the above prescription with 8 times the amount (weight ratio) of 70% ethanol, the first time was 3 hours, the second time was 2 hours, and combined The extract is filtered, and the filtrate is decompressed to recover ethanol, concentrated to 60°C to measure the clear paste with a relative density of 1.25, and set aside;

[0067] (2) Distill cinnamon sticks and tangerine peel to extract volatile oil according to the proportion, filter the aqueous solution after oil extraction, and set aside, add 8 times the amount of water to the ...

Embodiment 2

[0070] Embodiment 2: the preparation of pill

[0071] prescription:

[0072] Astragalus 425 g, Aconite 89.5 g, Ginseng 90 g, Salvia miltiorrhiza 220 g, Tinglizi 125 g, Xiangjia bark 65 g, Alisma 200 g, Polygonatum 30 g, Guizhi 85 g, Safflower 85 g, Tangerine peel 70 g

[0073] Preparation:

[0074] (1) Extract astragalus, Tinglizi, Alisma, ginseng, and Cyperus bark with 7 times the amount of 70% ethanol, filter, and concentrate the extract to a clear paste with a relative density of 1.30 when thermally measured at 60°C;

[0075] (2) extract the volatile oil of cinnamon sticks and tangerine peel;

[0076] (3) Aconite, Danshen, Yuzhu, and safflower were decocted twice with 6 times the amount of water, 2 hours each time, combined the extracts, filtered, combined with the aqueous solution of cinnamon sticks and tangerine peel in step (2), and concentrated to 60°C Measure the relative density of 1.30 clear ointment, add ethanol during stirring until the alcohol concentration ...

Embodiment 3

[0078] Embodiment 3: the preparation of pharmaceutical tablet of the present invention

[0079] prescription:

[0080] Astragalus 170 g, Aconite 45 g, Codonopsis 190 g, Salvia 80 g,

[0081] Tinglizi 70 g, Acanthopanax bark 170 g, Alisma 90 g, Polygonatum 65 g,

[0082] Guizhi 40 g, safflower 45 g, tangerine peel 30 g

[0083] Preparation:

[0084] (1) Astragalus, Tinglizi, Alisma, Codonopsis pilosula, and Acanthopanax bark were reflux extracted twice according to the above prescription plus 9 times the amount of 70% ethanol, the first time was 3 hours, the second time was 2 hours, and the extracts were combined. Filtrate, mix the filtrate with the alcohol extraction paste from step (1), and dry at 70°C;

[0085] (2) Distill cinnamon sticks and tangerine peel to extract volatile oil according to the prescription amount, filter the aqueous solution after oil extraction, and set aside, add 8 times the amount of water to the residue and decoct for 1 hour, filter, combine th...

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Abstract

The invention discloses an application of a traditional Chinese medicine composition in preparation of a drug for treating transient ischemic attack, wherein the traditional Chinese medicine composition is prepared from 11 traditional Chinese medicines including astragalus membranaceus, ginseng, salviae miltiorrhizae and the like. A clinical experiment proves that the traditional Chinese medicine composition is significant in treatment effects on the transient ischemic attack.

Description

technical field [0001] The invention relates to a new application of a traditional Chinese medicine composition, in particular to an application of a traditional Chinese medicine composition in the preparation of a medicine for treating transient ischemic attack. Background technique [0002] Transient ischemic attack (TIA) refers to a transient neurological dysfunction syndrome caused by local transient insufficient blood supply of the internal carotid artery system or vertebrobasilar artery system. Sexuality and recurrence are its main clinical features, and it is more common in middle-aged and elderly people over 50 years old. TIA is an early clinical manifestation of ischemic stroke, and the more frequent the TIA, the greater the risk of stroke. 10%-37% of TIA patients can develop complete stroke within 3-5 years, from the first TIA attack to the development of stroke, most of them occur within the first year after TIA, and within the first 2 months after TIA The risk ...

Claims

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Application Information

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IPC IPC(8): A61K36/8969A61K9/48A61P9/10A61P9/02
Inventor 常丽萍魏聪周梦夏张丽丽
Owner HEBEI YILING MEDICINE INST
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