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Application of composite containing polygonum orientale in preparing medicaments for preventing and treating diabetes and complication thereof

A technology of diabetes and composition, which is applied in the direction of medical preparations containing active ingredients, drug combinations, metabolic diseases, etc., and can solve problems such as no prevention and treatment of diabetes

Active Publication Date: 2011-09-07
GUIZHOU YIBAI PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is mainly used for coronary heart disease angina pectoris with heart-blood stagnation syndrome, symptoms include chest tightness, chest pain, immobility, palpitations, dark purple lips and tongue, thready and astringent pulse, etc. Reports on clinical pharmacological research on the prevention and treatment effect of herbal preparations on diabetes

Method used

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  • Application of composite containing polygonum orientale in preparing medicaments for preventing and treating diabetes and complication thereof
  • Application of composite containing polygonum orientale in preparing medicaments for preventing and treating diabetes and complication thereof
  • Application of composite containing polygonum orientale in preparing medicaments for preventing and treating diabetes and complication thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0092] 5 parts of Chinese Radix, 4 parts of hawthorn leaves, 3 parts of Panax notoginseng and 3 parts of Rhizoma Chuanxiong (parts are parts by weight, and the following examples are parts by weight)

[0093]Add 10 times the amount of water to decoct Chinese weed grass, hawthorn leaves, and Panax notoginseng 3 times, each time for 1 hour, filter, combine the filtrate, concentrate under reduced pressure to a relative density of 1.10, add ethanol to make the alcohol content reach 65%, stir evenly, Stand still for 12 hours, filter with suction, recover ethanol from the filtrate under reduced pressure and concentrate to a relative density of 1.07, add an appropriate amount of water to dilute, use a macroporous adsorption resin column with an upper diameter to height ratio of 1:10, and an adsorption flow rate of 2BV·h -1 , discard the breakthrough solution, wash with 1BV water, flow rate 2BV·h -1 , discard the water washing solution, and then eluted with 3BV70% ethanol at a flow ra...

Embodiment 2

[0096] Mix the extract mixture of Orientia radiata, hawthorn leaves, Panax notoginseng and Rhizoma Chuanxiong obtained in Example 1, and prepare an injection by using conventional techniques of pharmacy.

Embodiment 3

[0098] 6 parts of Chinese weed, 5 parts of hawthorn leaves, 4 parts of Panax notoginseng and 3 parts of Chuanxiong

[0099] Add 10 times the amount of water to decoct the weed grass and hawthorn leaves 3 times, 1 hour each time, filter, combine the filtrate, concentrate under reduced pressure to a relative density of 1.10, add ethanol to make the alcohol content reach 65%, stir evenly, and let stand for 12 hour, suction filtration, the filtrate decompressed to recover ethanol and concentrate to a relative density of 1.07, add appropriate amount of water to dilute, the upper diameter height ratio of 1:10 macroporous adsorption resin column, adsorption flow rate 2BV h -1 , discard the breakthrough solution, wash with 1BV water, flow rate 2BV·h -1 , discard the water washing solution, and then eluted with 3BV70% ethanol at a flow rate of 2BV·h -1 , collecting the eluate, recovering ethanol, concentrating into a thick paste, spray-drying the residue, and pulverizing into a fine p...

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Abstract

The invention discloses the application of a composite containing polygonum orientale in preparing medicaments for preventing and treating diabetes and complication thereof. The composite is prepared from extracts of polygonum orientale, panax notoginseng, hawthorn leaves and Rhizoma Chuanxiong. The invention provides a novel medical application of the composite containing polygonum orientale anda new medicine selection for patients.

Description

technical field [0001] The present invention relates to the application of the composition, in particular to the application of the composition containing the wolverine in the preparation of medicines for preventing and treating diabetes and its complications. technical background [0002] Diabetes Mellitus (DM) is a common endocrine and metabolic disorder and frequently-occurring disease. Prolonged illness can cause multi-system damage, leading to eye, kidney, nerve, heart, blood vessel and other diseases. With the aging of the population, the economic development of various countries and the change of people's lifestyle, the prevalence of diabetes is increasing rapidly around the world, seriously threatening human health. Currently, the number of DM patients worldwide has reached 150 million, and it is predicted to reach 300 million by 2025. In recent years, the prevalence of DM in my country has increased rapidly. In 2002, there were about 40 million DM patients, of whic...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/734A61K36/704A61P3/10
Inventor 窦啟玲
Owner GUIZHOU YIBAI PHARMA CO LTD
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