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Sulfalene oxazole molecular engram polymer producing method

A sulfamethoxazole and molecular imprinting technology is applied in the field of bioengineering to achieve the effects of overcoming serious impurity interference, shortening reaction time, and selecting and identifying excellent performance.

Inactive Publication Date: 2008-08-20
NANKAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently, there is little literature on the use of ionic liquids for molecularly imprinted polymerization

Method used

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  • Sulfalene oxazole molecular engram polymer producing method
  • Sulfalene oxazole molecular engram polymer producing method
  • Sulfalene oxazole molecular engram polymer producing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Weigh 0.25mmol template molecule sulfamethoxazole (SMO), 1mmol functional monomer methacrylic acid (MAA), and dissolve them in 2ml ionic liquid ([BMIM]BF 4 ) in an ampoule bottle, vibrate for 30min to make the template and functional monomer interact to form a complex, then add 5mmol of cross-linking agent ethylene glycol dimethacrylate (EDMA) and initiator azobisiso Butyronitrile (AIBN) 12mg, and mol ratio is SMO: MAA: EDMA=1: 4: 20, the ratio of the volume consumption of porogen and the molar weight of template molecule sulfamethoxazole is 8ml / mmol; After mixing, The molecularly imprinted solution was ultrasonically degassed, sonicated for 10 minutes, nitrogen gas was introduced for 10 minutes to deoxygenate, and finally the ampoule was vacuum-sealed, and then the ampoule was sealed under vacuum and reacted in a water bath at 60°C for 10 hours.

[0023] The resulting polymer was ground and sieved, and the polymer with a particle size of 40 μm-54 μm was screened out, a...

Embodiment 2

[0025] Weigh 0.25mmol template molecule sulfamethoxazole (SMO), 1mmol functional monomer methacrylic acid (MAA), dissolve them in 3ml ionic liquid ([BMIM]BF 4 ) in an ampoule bottle, vibrate for 30min to make the template and functional monomer interact to form a complex, then add 5mmol of cross-linking agent ethylene glycol dimethacrylate (EDMA) and initiator azobisiso Butyronitrile (AIBN) 12mg, and mol ratio is SMO: MAA: EDMA=1: 4: 20, the ratio of the volume consumption of porogen and the molar weight of template molecule sulfamethoxazole is 12ml / mmol; After mixing, The molecularly imprinted solution was ultrasonically degassed, sonicated for 10 minutes, nitrogen gas was introduced for 10 minutes to deoxygenate, and finally the ampoule was vacuum-sealed, and then the ampoule was sealed under vacuum and reacted in a water bath at 60°C for 10 hours.

[0026] The resulting polymer was ground and sieved, and the polymer with a particle size of 40 μm-54 μm was screened out, and ...

Embodiment 3

[0028] Weigh 0.25mmol template molecule sulfamethoxazole (SMO), 1mmol functional monomer methacrylic acid (MAA), dissolve them in 4ml ionic liquid ([BMIM]BF 4) in an ampoule bottle, vibrate for 30min to make template and functional monomer interact to form a complex, then add 5mmol crosslinking agent ethylene glycol dimethacrylate (EDMA) and initiator azobisiso Butyronitrile (AIBN) 12mg, and mol ratio is SMO: MAA: EDMA=1: 4: 20, the ratio of the volume consumption of porogen and the molar weight of template molecule sulfamethoxazole is 16ml / mmol; After mixing, The molecularly imprinted solution was ultrasonically degassed, sonicated for 10 minutes, nitrogen gas was introduced for 10 minutes to deoxygenate, and finally the ampoule was vacuum-sealed, and then the ampoule was sealed under vacuum and reacted in a water bath at 60°C for 10 hours.

[0029] The resulting polymer was ground and sieved, and polymers with a particle size of 40 μm-54 μm were sieved to elute the template ...

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Abstract

The invention relates to a method for preparing molecularly imprinted sulfamethoxazole polymer with ionic liquid to be a pore-forming agent. The specific steps are as follows: functional monomers and template molecules are dissolved into the ionic liquid and crosslinker and initiator are added after oscillation. Nitrogen is added to eliminate oxygen after ultrasonic degasification, the liquid is sealed by vacuum-pumping, and the polymer is then obtained by thermal initiation reaction. The molecularly imprinted polymer is obtained by the steps of elution, desiccation and grinding etc. The molecularly imprinted sulfamethoxazole polymer prepared by the invention has evenly massive structure. Compared with traditional synthetic method, the method is characterized by taking ionic liquid as the pore-forming agent which has excellent catalytic effect for polymer reaction when in the synthesis process. The synthetic polymer has the advantages of excellent dispersity, easy grinding and good molecular recognition properties, which can be used as solid phase extracting agent and packing materials for liquid phase chromatography to realize dispersion, concentration and purification of sulfonamides and resolving the defect of serious impurity interference of the existing common chromatographic detection.

Description

【Technical field】: [0001] The invention belongs to the technical field of bioengineering, and relates to the preparation of a molecularly imprinted polymer, in particular to the preparation of a molecularly imprinted polymer with specific recognition for sulfamethoxazole molecules. 【Background technique】: [0002] Sulfonamides are a class of commonly used artificially synthesized antibacterial drugs. They contain p-aminobenzenesulfonamide structure and have a good effect on stimulating the growth of animals. It is widely used in clinical and veterinary disease prevention and feed additives due to the advantages of convenient use. However, studies have shown that sulfa drugs are easy to remain in animals, and can easily cause adverse symptoms such as allergies, aplastic anemia, and urinary dysfunction after being eaten by humans. Therefore, the detection of sulfa drugs in actual samples is of great significance. Sulfamethoxzaloe (SMO), also known as sulfamethoxazole, is a wh...

Claims

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Application Information

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IPC IPC(8): C08F220/06C08F2/44C08K5/55C08K5/435C08J9/26B01J20/285
Inventor 陈朗星汪莲艳王新何锡文张玉奎王彦芬
Owner NANKAI UNIV
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