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Compound sulfonamide suspensoid and its preparing process

A compound sulfonamide and suspension technology, which is applied in the field of medicine and achieves the effects of no adverse reactions, good stability and easy taking

Active Publication Date: 2007-02-07
SUZHOU KEMU ANIMAL MEDICATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is widely used clinically, but there is no manufacturer producing sulfonamide suspending agent

Method used

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] A compound sulfonamide suspension, its prescription is:

[0041] Sulfadiazine (SD) 10kg

[0042] Sulfamethoxazole (SMZ) 6kg

[0043] Sulfamethoxine (SMD) 4kg

[0044] Trimethoprim (TMP) 4kg

[0045] Sodium alginate 0.8kg

[0046] Citric acid 1kg

[0047] Sodium hydroxide (1) (purity 96%) 3.9kg

[0048] Sodium hydroxide (2) (purity 96%) 0.6kg

[0049] Sodium sulfite 0.25kg

[0050] EDTA disodium salt 0.05kg

[0051] Purified water up to 100L

[0052] The preparation method of described compound sulfonamide suspension comprises the steps:

[0053] (1) Take the amount of sodium alginate and EDTA-2Na in the prescription, add 20 liters of purified water to soak overnight, dissolve——liquid A

[0054] (2) Take 28 liters of purified water and add the amount of sodium hydroxide in the prescription (1) Stir to dissolve, add the amount of sulfadiazine (SD), sulfamethoxazole (SMZ) and sulfamethoxine (SMD) in the prescription respectively , stirred while heating until com...

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Abstract

Disclosed is a compound sulfonamide turbid agent which comprises the following constituents (by weight percent): sulfadiazine 8-12, sulfamethoxazole 4-8, sulfamethoxydiazine 2-6, trimethoprim 2-6, and medicinal auxiliary materials including acid-base scale modifier, suspension auxiliary agent, acidifying agent, anti-oxidant, stabilizer and purified water.

Description

technical field [0001] The invention mainly relates to the field of medicine, in particular to a compound sulfonamide suspension for treating diseases in animals and a preparation method thereof. Background technique [0002] Sulfonamides are the first chemotherapy drugs discovered in the 1930s that can effectively prevent and treat systemic bacterial infections. It has been mostly replaced by antibiotics and quinolones in clinical practice, but because sulfa drugs have the advantages of good curative effect on certain infectious diseases (such as meningitis and plague), convenient use, stable properties, and low price, so It still occupies a certain position in the anti-infective drugs. [0003] Combination of sulfonamides and sulfa synergist trimethoprim at a ratio of 4:1 or 5:1 can significantly enhance the clinical curative effect and enhance the antibacterial effect by several to dozens of times. In recent years, some foreign sulfonamides hav...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61K31/635A61K47/38A61P31/04
Inventor 张志成
Owner SUZHOU KEMU ANIMAL MEDICATION
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