Spray film forming preparation for burn and scald injury

A spray film forming and preparation technology, which is applied in the field of medicine, can solve the problems of cross contamination, inconvenient use, and affecting the treatment effect, and achieve the effect of recovery

Inactive Publication Date: 2015-02-18
南京泽恒医药技术开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] After burns and scalds on the human skin, semi-solid drugs such as creams and gels are generally used to treat the injured skin. These drugs are usually applied to the surface of the wound by fingers or utensils, which is easy to cause drug coating. Inhomogeneity and cross-contamination affect the treatment e

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0028] Example 1

[0029] prescription

[0030] Silver Sulfadiazine 10g

[0031] Polyvinyl alcohol (17-88) 5g

[0032] Hydroxypropyl cellulose (EF) 25g

[0033] Glycerin 10g

[0034] Talc 15g

[0035] Silica 3g

[0036] Sorbic acid 0.3g

[0037] Deionized water up to 500g

[0038] Preparation:

[0039] Boil deionized water and put it in a stainless steel container, add the prescription amount of polyvinyl alcohol to boiling water, stir to dissolve, then add hydroxypropyl cellulose and sorbic acid to the stainless steel container, fully swell and dissolve at room temperature for 24 hours, and make A solution containing polyvinyl alcohol and hydroxypropyl cellulose; add micronized silver sulfadiazine to the above polymer material solution, stir and mix evenly, add glycerin, add talc and silicon dioxide to the mixture, stir and mix for 10 minutes; Stir the sodium hydroxide at a pH of about 6-8 at the same time to form a uniform suspension. After passing the inspection...

Example Embodiment

[0040] Example 2

[0041] prescription

[0042] Zinc Sulfadiazine 25g

[0043] Polyvinyl alcohol (17-88) 5g

[0044] Hypromellose (50CP) 10g

[0045] Glycerin 15g

[0046] Talcum powder 20g

[0047] Dioxide peptide 2.0g

[0048] Sodium benzoate 0.4g

[0049] Deionized water 500g

[0050] Preparation:

[0051] Boil deionized water and place it in a stainless steel container, add the prescription amount of polyvinyl alcohol to boiling water, stir to dissolve, and then add hypromellose and sodium benzoate to the stainless steel container to fully swell at room temperature for 24 hours to make A solution containing polyvinyl alcohol and hypromellose; add micronized zinc sulfadiazine to the above polymer material solution, stir and mix well, add glycerin, add talc and peptide dioxide to the mixture, stir and mix for 10 minutes ; When necessary, adjust the pH to about 6-8 with sodium hydroxide or hydrochloric acid while stirring. A uniform suspension is formed, and each s...

Example Embodiment

[0052] Example 3

[0053] prescription

[0054] Sulfadiazine 10g

[0055] Polyvinyl alcohol (17-88) 15g

[0056] Hydroxypropyl cellulose (MF) 10g

[0057] Glycerin 25g

[0058] Talc 15g

[0059] Silica 10g

[0060] Benzoic acid 0.2g

[0061] Deionized water 500g

[0062] Preparation:

[0063] Heat deionized water and boil it in a stainless steel container, add the prescription amount of polyvinyl alcohol to boiling water, stir to dissolve, and then add hydroxypropyl cellulose and benzoic acid to the stainless steel container to fully swell and dissolve at room temperature for 24 hours to make Solution containing polyvinyl alcohol and hydroxypropyl cellulose; add micronized sulfadiazine to the above polymer material solution, stir and mix evenly, add glycerin, add talc and silicon dioxide to the mixture, stir and mix for 10 minutes to form a uniform After passing the inspection, fill each spray bottle with about 10ml.

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Abstract

The invention discloses a spray film forming preparation for burn and scald injury. The preparation contains sulfadiazine, a biocompatible macromolecular film forming component with at least 2% by weight of polyvinyl alcohol and hydroxy propyl methyl cellulose (HPMC), a plasticizer, an anti-sticking agent and a bacteriostatic agent which are combined. According to the spray film forming preparation, sulfadiazine, the film forming component, the anti-sticking agent and the plasticizer are mixed to form suspension, the suspension is sprayed to the burned skin, and a film is formed.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a convenient spray film-forming preparation prepared from sulfadiazine-containing medicines. The spray film-forming preparation has a good therapeutic effect on burns and scalds. Background technique [0002] After burns and scalds on human skin, semi-solid drugs such as creams and gels are generally used to treat the injured skin. These drugs are usually applied to the surface of the wound by fingers or utensils, which is easy to cause drug coating. Inhomogeneity and cross-contamination will affect the treatment effect. [0003] At present, sulfadiazine drugs are widely used in the treatment of burns and scalds, and the adopted dosage forms are common external preparations such as creams for treatment. Such common preparations are not suitable for wound treatment. Cloth is easy to cause cross-contamination, and it is inconvenient to use. The present invention aims at solving th...

Claims

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Application Information

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IPC IPC(8): A61K9/12A61K31/63A61K47/38A61P17/02A61P31/04
Inventor 张自强刘宇婧
Owner 南京泽恒医药技术开发有限公司
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