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Compound sulfadiazine injection and preparation method thereof

A technology for sulfonic acid injection and compound prescription, which is applied in the field of compound sulfonic acid injection and its preparation, can solve the problems of drug production, reduce curative effect and the like, and achieve the effects of enhancing curative effect, improving therapeutic effect and expanding antibacterial spectrum.

Inactive Publication Date: 2011-03-30
TIANJIN BIJIA PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For decades, oxytetracycline has been listed as the first-choice drug for the treatment of porcine toxoplasmosis. Due to the long-term repeated use of antibiotics, Toxoplasma has developed drug resistance to the drug, which reduces the curative effect

Method used

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  • Compound sulfadiazine injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] A compound liansulfon injection, the components and parts by weight are as follows:

[0020] 5 parts of sulfamethoxine sodium, 1 part of trimethoprim (TMP), 0.1 part of anhydrous sodium sulfite, 0.01 part of disodium edetate, 8 parts of sulfamethoxazole, 20 parts of propylene glycol, 1 part of ethanolamine , 79 parts of water for injection,

[0021] A preparation method of compound liansulfon injection, the steps are as follows:

[0022] (1) TMP and propylene glycol are mixed and dissolved, and sulfamethoxine sodium is added to stir and dissolve;

[0023] (2) After diluting 1-5 parts of ethanolamine with water to 12 parts, add sulfamethoxazole to dissolve;

[0024] (3) Combine the solutions prepared by "(1)" and "(2)", add water for injection to the full amount, stir evenly, and keep for 15-20 minutes to obtain Compound Liansulfon Injection.

Embodiment 2

[0026] A compound liansulfon injection, the components and parts by weight are as follows:

[0027] 12 parts of sulfamethoxine sodium, 5 parts of trimethoprim (TMP), 0.3 parts of anhydrous sodium sulfite, 0.05 parts of disodium edetate, 10 parts of sulfamethoxazole, 50 parts of propylene glycol, and 5 parts of ethanolamine , 45 parts of water for injection,

[0028] A preparation method of compound liansulfon injection, the steps are as follows:

[0029] (1) TMP and propylene glycol are mixed and dissolved, and sulfamethoxine sodium is added to stir and dissolve;

[0030] (2) After diluting 1-5 parts of ethanolamine with water to 12 parts, add sulfamethoxazole to dissolve;

[0031] (3) Combine the solutions prepared by "(1)" and "(2)", add water for injection to the full amount, stir evenly, and keep for 15-20 minutes to obtain Compound Liansulfon Injection.

Embodiment 3

[0033] A compound liansulfon injection, the components and parts by weight are as follows:

[0034] 10 parts of sulfamethoxine sodium, 3 parts of trimethoprim (TMP), 0.2 parts of anhydrous sodium sulfite, 0.03 parts of disodium edetate, 9 parts of sulfamethoxazole, 30 parts of propylene glycol, 3 parts of ethanolamine , 67 parts of water for injection,

[0035] A preparation method of compound liansulfon injection, the steps are as follows:

[0036] (1) TMP and propylene glycol are mixed and dissolved, and sulfamethoxine sodium is added to stir and dissolve;

[0037] (2) After diluting 1-5 parts of ethanolamine with water to 12 parts, add sulfamethoxazole to dissolve;

[0038] (3) Combine the solutions prepared by "(1)" and "(2)", add water for injection to the full amount, stir evenly, and keep for 15-20 minutes to obtain Compound Liansulfon Injection.

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Abstract

The invention discloses a compound sulfadiazine injection and a preparation method thereof. The compound injection comprises the following components in parts by weight: 5-12 parts of sulfamonomethoxine sodium, 1-5 parts of trimethoprim (TMP), 0.1-0.3 part of anhydrous sodium sulfite, 0.01-0.05 part of disodium ethylene diamine tetraacetate, 8-10 parts of sulfamethoxazole, 20-50 parts of propylene glycol, 1-5 parts of ethanolamine and 45-79 parts of injection water. Compared with the single sulfamonomethoxine sodium, the compound preparation prepared from the sulfamonomethoxine sodium, the sulfamethoxazole and the TMP expands an antibacterial spectrum, enhances the curative effect of the injection and enlarges the clinical application range; and the compound preparation can be applied to treating infection caused by bacteria as well as fever, high fever and dyspnea caused by toxoplasma, and the preparation has better treatment effect on diseases such as appetite decrease and even anorexia, diarrhea and the like.

Description

technical field [0001] The invention belongs to the field of veterinary drug injection, in particular to a compound liansulfon injection and a preparation method thereof. Background technique [0002] Porcine toxoplasmosis is one of the most common diseases in pig herds, which seriously restricts the development of pig industry. Over the past decades, oxytetracycline has been listed as the first-choice drug for the treatment of porcine toxoplasmosis. Due to the long-term repeated use of antibiotics, Toxoplasma has developed drug resistance to the drug, which reduces the curative effect. [0003] According to retrieval, find following patent document, wherein patent document CN1879633 discloses a kind of veterinary compound liansulfon injection, preparation method and application, veterinary compound liansulfon injection is made with following method: (1) take propylene glycol heating and add Trimethoprim, stirring to dissolve, cooling, adding ethanol, stirring evenly, then ...

Claims

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Application Information

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IPC IPC(8): A61K31/635A61K31/505A61K9/08A61P31/04A61P33/02A61P29/00A61P11/00A61P1/14A61P1/12
Inventor 马明娟李华声裴毅聂江力
Owner TIANJIN BIJIA PHARMA CO LTD
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