Ointment for relieving swelling and ostealgia and promoting tissue regeneration and preparation method thereof

Abstract

The invention discloses ointment for relieving swelling and ostealgia and promoting tissue regeneration and a preparation method thereof, and relates to the field of traditional Chinese medicine, and the ointment is prepared from the following raw materials: catechu, cape jasmine, trogopterus dung, kadsura root-bark, madder, dragon's blood, rheum officinale, frankincense and myrrh. According to the swelling-eliminating ostealgia granulation-promoting ointment and the preparation method thereof, by scientifically compounding a plurality of traditional Chinese medicinal materials capable of promoting blood circulation to remove blood stasis and promoting granulation to relieve pain and combining with an accurate grinding process and an optimized proportion of a honey matrix, the medicine permeability and bioavailability of the ointment are remarkably improved; the traditional Chinese medicine composition has multiple effects of relieving swelling and pain, promoting blood circulation to remove blood stasis, relaxing tendons and activating collaterals, and promoting tissue regeneration and strengthening muscles and bones, and particularly has a more remarkable curative effect on edema pain caused by rheumatism, rheumatoid, gout and various osteoarthropathy and diseases such as early bone fracture, bone fracture and fracture.

Description

Technical Field

[0001] The invention relates to traditional Chinese medicine technology, and in particular to a swelling-reducing, bone-pain-regenerating and muscle-promoting ointment and a preparation method thereof. Background Art

[0002] In the field of traditional Chinese medicine external treatment, Chinese medicine ointments are widely used in the treatment of bruises, sores, swelling and pain, and sequelae of bone injuries because of their characteristics of directly acting on the affected area and taking effect quickly. Although there are many functional plasters on the market, such as anti-swelling and analgesic ointment for rheumatoid arthritis, musk wind-chasing ointment for treating low back and leg pain, and blood-activating and stasis-removing patches for treating bruises, most products are still limited to single prescriptions or simple compound prescriptions, and have limitations such as slow release of active ingredients, single target of action, and insufficient comprehensive conditioning ability, resulting in long treatment cycles and unclear treatment effects. Summary of the Invention

[0003] The present invention aims to provide a swelling-reducing, bone-pain-regenerating and muscle-promoting ointment and a preparation method thereof, so as to solve the problems of the prior art traditional Chinese medicine ointments having a single effect, insufficient conditioning, a long treatment cycle and poor effect.

[0004] In order to achieve the above-mentioned purpose, the present invention provides a swelling-reducing, bone-pain-relieving and tissue-promoting ointment on one hand, which is prepared from the following raw materials in parts by weight: 200-300 parts of catechu, 80-150 parts of gardenia, 80-150 parts of aconite, 200-300 parts of bauhinia bark, 80-120 parts of madder, 200-300 parts of dragon's blood, 80-120 parts of rhubarb, 120-180 parts of frankincense, and 80-120 parts of myrrh.

[0005] Furthermore, it is prepared from the following raw materials in parts by weight:

[0006] 250 parts of catechu, 120 parts of gardenia jasmine, 120 parts of cinnamon bark, 250 parts of red chinensis bark, 100 parts of madder, 250 parts of dragon's blood, 100 parts of rhubarb, 150 parts of frankincense, 100 parts of myrrh.

[0007] Another aspect of the present invention provides a method for preparing the above-mentioned swelling-reducing, bone-pain-regenerating and muscle-promoting ointment, comprising the following steps:

[0008] S1. Weigh the formula amount of catechu, gardenia, pentastract, redbud bark, madder, dragon's blood, rhubarb, frankincense, and myrrh, and grind them into fine powder with a particle size that can pass through a 100-mesh sieve;

[0009] S2. Evenly mix the fine powder obtained in step S1, add fresh pure honey to neutralize and mix into a paste.

[0010] Furthermore, in step S2, the amount of honey added is 30%-50% of the total weight of the fine powder.

[0011] Catechu is bitter and cool in nature, and has the effects of promoting blood circulation, relieving pain, stopping bleeding and promoting tissue regeneration. It can promote wound repair and inhibit local inflammatory response. Its astringent effect helps reduce tissue exudation. At the same time, it has an inhibitory effect on pathogens such as Staphylococcus aureus. It is the core antibacterial and tissue regeneration ingredient in paste prescriptions.

[0012] Gardenia is cold and bitter in nature, and is good at clearing away heat from the triple burner. Ingredients such as gardenia glycoside can significantly inhibit the synthesis of prostaglandins and exert antipyretic and analgesic effects. Its blood-cooling and swelling-reducing properties can relieve the redness, swelling, heat and pain caused by traumatic injuries, and at the same time accelerate the absorption of blood stasis by promoting the recovery of capillary permeability.

[0013] Wulingzhi has a sweet and warm taste, and is mainly used to promote blood circulation, disperse blood stasis, relieve pain and stop bleeding. The urea, resin and other ingredients it contains can dilate blood vessels and improve microcirculation. Its unique anti-thrombotic effect can prevent blood stasis. It can be used together with frankincense and myrrh to enhance the effect of promoting blood circulation and relieving pain. It is especially suitable for chronic injuries caused by falls.

[0014] Bauhinia bark is bitter and flat, and is specifically used to promote blood circulation and unblock the meridians. Modern pharmacology has confirmed that the bauhinia saponins it contains can inhibit mast cell degranulation, reduce the release of inflammatory mediators such as histamine, and have a significant effect on relieving swelling and pain caused by acute soft tissue injuries, and also have anti-rheumatic effects.

[0015] Rubia cordifolia is bitter and cold, good at cooling blood, stopping bleeding, promoting blood circulation and removing blood stasis. The anthraquinone components it contains can shorten coagulation time and promote fibrinolysis. Its bidirectional regulatory effect can prevent bleeding and improve blood stasis. It is particularly suitable for the pathological state of post-traumatic blood stasis, swelling and pain accompanied by microcirculation disorders.

[0016] Xuejie is a mild herb with a sweet and salty flavor. It is an important medicine for promoting blood circulation, dispersing blood stasis, relieving pain and stopping bleeding. The dragon's blood pigment it contains can significantly increase capillary resistance and reduce traumatic exudation. At the same time, it exerts a strong analgesic effect by inhibiting the release of 5-hydroxytryptamine. It is the core drug in paste prescriptions to improve local blood circulation.

[0017] Rhubarb is bitter and cold, and has the functions of clearing heat and detoxifying, promoting blood circulation and removing blood stasis. The chrysophanol it contains can inhibit the expression of inflammatory factors and reduce capillary permeability. Its laxative effect indirectly reduces tissue edema by promoting intestinal peristalsis, and it has significant astringent and tissue-generating effects when used externally.

[0018] Frankincense is pungent and warm, and is good at promoting blood circulation and qi, reducing swelling and relieving pain. Its volatile oil components can stimulate peripheral nerve receptors, improve local nutrition by reflex dilation of blood vessels, and at the same time promote the enhancement of phagocyte function, accelerate the absorption of inflammation, and have a softening effect on old scar tissue.

[0019] Myrrh is bitter and flat, and is used together with frankincense to double its ability to dispel blood stasis and relieve pain. Its resin components can reduce blood viscosity, inhibit platelet aggregation, and improve microcirculation disorders. When used with Sanguisorba officinalis, it can significantly enhance the effect of tissue regeneration and wound healing, and promote the growth of granulation tissue.

[0020] Fresh pure honey, which serves as the matrix, contains a variety of amino acids and active enzymes. In addition to harmonizing various medicines, its hypertonicity can form a protective film to prevent infection. The hydrogen peroxide produced by glucose oxidase has a broad-spectrum antibacterial effect. At the same time, it provides the nutrients needed for wound repair and promotes epithelial cell regeneration.

[0021] Compared with the existing technology, the present invention provides a swelling-reducing, bone-pain-regenerating and muscle-regenerating ointment and a preparation method thereof, which significantly improves the drug permeability and bioavailability of the ointment by scientifically compounding a variety of Chinese medicinal materials that promote blood circulation, remove blood stasis, promote muscle regeneration and relieve pain, combined with precise grinding technology and optimized ratio of honey matrix. Clinically verified, the prescription has multiple functions of reducing swelling and relieving pain, promoting blood circulation and removing blood stasis, relaxing muscles and tendons, and promoting muscle regeneration and strengthening bones and muscles. It is especially effective in treating edema and pain caused by rheumatism, rheumatoid arthritis, gout, and various bone and joint diseases, as well as early bone injuries, bone cracks, fractures and other diseases. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments. Obviously, the drawings described below are only some embodiments described in the present invention. For ordinary technicians in this field, other drawings can also be obtained based on these drawings.

[0023] Figure 1 The present invention provides a flow chart of the preparation method of the ointment for reducing swelling, bone pain and promoting tissue regeneration provided in an embodiment of the present invention. DETAILED DESCRIPTION

[0024] In order to enable those skilled in the art to better understand the technical solution of the present invention, the present invention will be further described in detail below with reference to the accompanying drawings.

[0025] Example 1

[0026] A swelling-reducing, bone-pain-regenerating and muscle-promoting ointment is prepared from the following raw materials by weight:

[0027] 250g catechu, 120g gardenia, 120g aconite root, 250g bauhinia bark, 100g madder, 250g dragon's blood, 100g rhubarb, 150g frankincense, 100g myrrh.

[0028] See also Figure 1 A method for preparing the above-mentioned swelling-reducing, bone-pain-regenerating and muscle-regenerating ointment comprises the following steps:

[0029] S1. Weigh the formula amount of catechu, gardenia, pentastract, redbud bark, madder, dragon's blood, rhubarb, frankincense, and myrrh, and grind them into fine powder with a particle size that can pass through a 100-mesh sieve;

[0030] S2. Mix the fine powder obtained in step S1 evenly, add fresh pure honey to neutralize and make into a paste;

[0031] The amount of honey added is 40% (576 g) of the total weight of the fine powder.

[0032] Paste properties: Brown viscous paste with fine texture and easy to apply.

[0033] Usage: Apply the prepared paste to the affected area and then wrap it with kraft paper, or apply it to the affected area with a medical plaster.

[0034] Catechu (bitter and cool, enters the heart and lung meridians) is the main drug. It has the effects of promoting blood circulation, relieving pain, promoting tissue regeneration and healing sores. It inhibits the release of TNF-α / IL-1β through catechins and promotes fibroblast proliferation, accelerating bone fracture repair and wound healing; Gardenia (bitter and cold, enters the heart, liver and lung meridians) clears heat, cools blood and reduces swelling. Its gardenia glycoside blocks the COX-2 / PGE2 pathway and specializes in the redness, swelling and burning pain of gout in the acute stage; Ophiopogon japonicus (bitter, sweet and warm, enters the liver meridian) promotes blood circulation and dredges the meridians, activates TRPV1 channels to inhibit bradykinin-induced pain, and synergistically enhances transdermal analgesia; Bauhinia bark (bitter and flat, enters the liver and spleen meridians) promotes blood circulation, dredges menstruation and reduces swelling. The tannins it contains constrict blood vessels and reduce capillary permeability, targeting joint edema; Rubia cordifolia (bitter and cold, enters the liver meridians) promotes blood circulation, dredges the meridians and reduces swelling. Liver meridian) cools blood and removes stasis, while rubiacin inhibits platelet aggregation, improves microcirculation, and resolves blood stasis; Xuejie (sweet, salty, and neutral, enters the heart and liver meridians) is another monarch drug, which regulates the VEGF pathway to promote angiogenesis in bone callus, and effectively activates blood circulation and regenerates muscles; Dahuang (bitter and cold, enters the spleen, stomach, and large intestine meridians) clears heat and removes blood stasis, while chrysophanol inhibits the NF-κB signaling pathway and clears the accumulation of inflammatory factors; Frankincense (pungent, pungent, and warm, enters the heart, liver, and spleen meridians) and Myrrh (bitter and neutral, enters the heart and liver meridians) are used together, with boswellic acid and mysaponin doubly inhibiting 5-lipoxygenase and substance P release, relaxing muscles and tendons, and dissipating pain from old injuries and blood stasis; all the drugs synergistically enhance their effectiveness in the honey sustained-release matrix, achieving the full effects of reducing swelling and relieving pain, activating blood circulation and regenerating muscles, and strengthening tendons and bones.

[0035] During the preparation process, the raw materials are ground into fine powder and micronized to increase the specific surface area of the medicinal materials, accelerate the dissolution of fat-soluble components (boswellic acid, dracoside), and promote the percutaneous penetration of rhubarb anthraquinone glycosides and gardenia glycosides into deep tissues. Subsequently, the fine powder is neutralized and adjusted into a paste by adding fresh pure honey. The fructose in the honey acts as a natural penetration enhancer and maintains the pH environment, thereby improving the efficacy of the anti-inflammatory, bone pain and muscle regeneration cream.

[0036] The swelling-reducing, bone-pain-regenerating ointment of the present invention is used to treat edema and pain caused by arthritis, rheumatoid arthritis, gout, various bone joint diseases, and early-stage bone injuries, fractures and bone fractures. Clinical practice has proved that the prescription has the effects of reducing swelling and relieving pain, promoting blood circulation and removing blood stasis, relaxing muscles and tendons, and promoting muscle growth and strengthening bones and tendons. It is especially effective for edema and pain caused by arthritis, rheumatoid arthritis, gout, various bone joint diseases, and early-stage bone injuries, fractures and bone fractures.

[0037] Example 2

[0038] A swelling-reducing, bone-pain-regenerating and muscle-promoting ointment is prepared from the following raw materials by weight:

[0039] 200g catechu, 80g gardenia, 80g aconite root, 200g bauhinia bark, 80g madder, 200g dragon's blood, 80g rhubarb, 120g frankincense, 80g myrrh.

[0040] Preparation method: Same as Example 1, except that the amount of honey added is 30% of the total weight of the fine powder.

[0041] Example 3

[0042] A swelling-reducing, bone-pain-regenerating and muscle-promoting ointment is prepared from the following raw materials by weight:

[0043] 300g catechu, 150g gardenia, 150g aconite root, 300g bauhinia bark, 120g madder, 300g dragon's blood, 120g rhubarb, 180g frankincense, 120g myrrh.

[0044] Preparation method: Same as Example 1, except that the amount of honey added is 30% of the total weight of the fine powder.

[0045] Clinical efficacy:

[0046] Study population: 100 volunteers were selected, all of whom were diagnosed with acute gouty arthritis (serum uric acid ≥ 480 μmol / L), aged 28 to 65 years; the disease course was 6 months to 8 years, and the clinical manifestations were redness, swelling, burning pain, and limited movement of the first metatarsophalangeal joint.

[0047] The subjects were randomly divided into 3 groups (Example 1 group and control group (commercially available gout ointment)), with 50 cases in each group.

[0048] Usage: Apply the swelling-reducing, bone-pain-regenerating and muscle-promoting ointment prepared in Example 1 evenly to the medical plaster and apply it to the affected area. Change the dressing once a day, and 5 days is a course of treatment.

[0049] Evaluation criteria:

[0050] Cure: After one course of treatment, joint redness, swelling and burning pain disappear, blood uric acid returns to normal (≤420μmol / L), and the patient can move freely;

[0051] Effective: After one course of treatment, redness and swelling subside, pain is reduced by ≥50%, and blood uric acid decreases by ≥30%;

[0052] Ineffective: No improvement in symptoms or blood uric acid.

[0053] Treatment evaluation results:

[0054] 50 patients with acute gouty arthritis who used the swelling-reducing, bone-pain-regenerating ointment prepared in Example 1 were evaluated for one course of treatment. 48 patients were evaluated as cured, 2 patients were evaluated as effective, and the blood uric acid level of the 48 cured patients remained stable at ≤400 μmol / L.

[0055] Among 50 patients with acute gouty arthritis who used the control group (commercially available gout ointment), 22 were evaluated as cured, 20 as effective, and 8 as ineffective after one course of treatment.

[0056] The above description is merely illustrative of certain exemplary embodiments of the present invention. It goes without saying that those skilled in the art will be able to modify the described embodiments in various ways without departing from the spirit and scope of the present invention. Therefore, the above drawings and description are illustrative in nature and should not be construed as limiting the scope of protection of the claims.

Claims

1. A swelling-reducing, bone-pain-regenerating and muscle-regenerating ointment, characterized in that: The invention is prepared from the following raw materials in proportion by weight: 200-300 parts of catechu, 80-150 parts of gardenia, 80-150 parts of cinnamon bark, 200-300 parts of red chinensis bark, 80-120 parts of madder, 200-300 parts of dragon's blood, 80-120 parts of rhubarb, 120-180 parts of frankincense and 80-120 parts of myrrh.

2. A swelling-reducing, bone-pain-regenerating and muscle-regenerating ointment according to claim 1, characterized in that: Made from the following raw materials in parts by weight: 250 parts of catechu, 120 parts of gardenia jasmine, 120 parts of cinnamon bark, 250 parts of red chinensis bark, 100 parts of madder, 250 parts of dragon's blood, 100 parts of rhubarb, 150 parts of frankincense, 100 parts of myrrh.

3. A method for preparing the ointment for reducing swelling, bone pain and promoting tissue regeneration as claimed in claim 1 or 2, characterized in that: The following steps are involved: S1. Weigh the formula amount of catechu, gardenia, pentastract, redbud bark, madder, dragon's blood, rhubarb, frankincense, and myrrh, and grind them into fine powder with a particle size that can pass through a 100-mesh sieve; S2. Evenly mix the fine powder obtained in step S1, add fresh pure honey to neutralize and adjust into a paste.

4. The preparation method of the anti-swelling and bone-pain-regenerating paste according to claim 3, characterized in that: In step S2, the amount of honey added is 30%-50% of the total weight of the fine powder.

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