45results about How to "Strong specificity recognition ability" patented technology

The invention belongs to the technical field of material chemistry, and discloses a molecular imprinting polymer for roxarsone detection, and a preparation method thereof. The molecular imprinting polymer preparation method comprises the following steps: carrying out polymerization of a template, a pore forming agent, a functional monomer, a cross-linking agent and an initiator for 8-48 h at a temperature of 50-80 DEG C, and removing the template to obtain the molecular imprinting polymer for roxarsone detection. According to the present invention, a roxarsone recovery rate of the prepared molecular imprinting polymer is more than 90%, and the prepared molecular imprinting polymer shows a high roxarsone cross reaction, has high selectivity and high specificity, and provides broad application prospects in the field of application of the prepared molecular imprinting polymer as a sample purification pretreatment material for roxarsone analysis in feeds, animal tissues, environment water and other matrixes.

The invention relates to a magnetic nanocomposite as well as a preparation method and an application thereof. The magnetic nanocomposite is characterized by being modified with a Fe2O3 layer with a hydrothermal method and is regular in morphology and uniform in distribution. The magnetic nanocomposite has good magnetic responsibility and specific recognition capacity, can be applied to various fields such as a medicine purification system, extraction and separation of effective components, food processing, cosmetics, chemical separation and analysis and the like, can be particularly applied to a complicated component system such as Chinese herbal medicines and the like and has potential industrial production and application values.

The invention relates to a preparation method for an integrated POSS and MCM-41-MPS doped capecitabine molecularly-imprinted sustained-release or controlled-release material, specifically to the preparation method and performance evaluation of a capecitabine molecularly-imprinted sustained-release or controlled-release material doped by POSS and the mesoporous molecular sieve MCM-41. Results showthat due to the existence of both POSS and MCM-41-MPS, the selective recognition ability and adsorption performance of a molecularly-imprinted polymer can be significantly improved, better imprintingeffect is generated, and certain influence is performed on the specific surface area and pore size distribution of the polymer. Hybrid MIP is used as a carrier material of capecitabine, and in-vitro and in-vivo drug release experiment results prove that an optimal formula is significantly prolonged in drug release time and significantly improved in relative bioavailability (wherein F is 173.4%), so great research significance and practical value are achieved when the hybrid MIP is applied to the sustained-release or controlled-release material of the capecitabine.

The invention relates to a conductive type sensing electrode for detecting chloramphenicol in the field of biosensors and a method for preparing a molecular engram membrane of the chloramphenicol. In the invention, the conductive type sensing electrode is formed by arranging two screen painting electrodes in parallel. The method for preparing the molecular engram membrane of the chloramphenicol comprises the following steps: template molecules are embedded in a direct in-situ polymerization process of polymer fluid on the surfaces of the disposable screen painting electrodes, and then the template molecules are eluted so that cavities with set sizes and shapes and functional groups in confirmed arrangement are formed in the molecular engram membrane and have memorability to stereoscopic structures of the template molecules. Chloramphenicol molecules in a sample to be detected can be combined with the specificity of the cavities so as to change the electrochemical properties of the molecular engram membrane, and increase the conductivity and the membrane conductance of the molecular engram membrane. The processing method of the invention has simplicity, convenience and low cost, and the conductive type sensing electrode made of the screen painting electrodes has convenient operation, high response time and long service life when used for detecting the chloramphenicol.

The invention belongs to the field of molecular imprinting detection, and in particular relates to an electrochemical sensor for measuring 2,4,6-trichlorophenol based on molecular imprinting technology and its preparation and application. In the present invention's electrochemical analysis technology for existing 2,4,6-trichlorophenol, 2,4,6-trichlorophenol and its structural analogues have similar oxidation potentials, resulting in insufficient specific recognition of the target good. The electrochemical sensor prepared in the present invention is based on molecular imprinting technology and can be used to selectively recognize 2,4,6-trichlorophenol. The electrode modification material uses carbon quantum dot-polymer composite film, which is low in cost and environmentally friendly; the sensor is simple to prepare, the reaction conditions are mild, the process is easy to control, and it has good sensitivity to template molecules and strong anti-interference. Can be used for quantitative analysis of 2,4,6-trichlorophenol.

The invention discloses a preparation method of a molecularly imprinted composite material for enriching and separating glycoproteins, belonging to the fields of material science and engineering and biological separation engineering. In this method, the surface of graphene oxide is firstly functionalized with boric acid, the template glycoprotein is fixed on the surface of graphene oxide through boron affinity, and the surface imprinting technology is used to form a protein imprinted layer on the surface of graphene oxide, and the template is eluted to obtain molecular imprinting. composite material. The molecularly imprinted composite material prepared by this method has a very good ability to specifically recognize the template glycoprotein, and also has the advantages of high binding capacity, strong anti-interference ability, fast binding and elution speed, and can be used for complex practical applications. The low-concentration glycoproteins in the sample are enriched, separated and detected.

The invention belongs to the field of molecular imprinting sensor field, and more specifically relates to a method used for photocatalysis RAFT polymerization preparation of a molecular imprinting sensor. The method mainly comprises following steps: a compound containing a tertiary amine structure is taken as a template molecule, and a template molecule-functional monomer pre-polymerized solutionis synthesized; tris (bipyridine) ruthenium is taken as both as a photocatalyst and an electrochemiluminescence agent, photocatalysis RAFT polymerization is carried out, and synthesis of a molecular imprinting polymer with a structure and a size similar to those of the template molecule is realized; and at last, a molecular imprinting sensor is obtained. The molecular imprinting sensor is high inspecific identifying capacity, can be used for quantitative determination, and the lowest detection lower limit concentration reaches 1*10<-13>mol / L. According to the preparation method, no extra polymerization initiator is needed, the process is more simple, is high in efficiency, is green, and is friendly to the environment.

The invention relates to a silk screen printing electrode and a method for synthesizing chloramphenicol molecularly imprinted membrane, belonging to the macromolecule technical field. The invention embeds template molecules in the direct surface in-situ polymerization of a one-time silk screen printing electrode and elutes the template molecules, to form the cavities of fixed sizes and shapes andthe function groups of a fixed arrangement in the molecularly imprinted membrane, therefore, the molecularly imprinted membrane has shape memory property to the stereo structure of the template molecules, the chloramphenicol molecule of the object sample can be combined with the cavity specifically, to modify the electromechanical property of the molecularly imprinted membrane to improve the electric conductivity of the molecularly imprinted membrane and improve membrane passing current. The silk screen printing electrode coated with a chloramphenicol molecularly imprinted membrane can be connected with a current sensor to quickly and sensitively detect chloramphenicol density. The molecularly imprinted membrane can be used to detect chloramphenicol, having simple sample pretreatment, short detection time, strong interference resistance and batch production.

The invention provides a magnetic nano-material based on inorganic boric acid modification as well as a preparation method and application of the magnetic nano-material; the magnetic nano-material is obtained by modifying a layer of inorganic boric acid or salt compounds of the inorganic boric acid on the magnetic nano-material. The magnetic nano composite material is regular in shape and uniform in distribution, has excellent magnetic responsiveness, and specific recognition capability, can be used in many fields, such as the aspects of medicine purification systems, active ingredient extraction and separation, food processing, cosmetics, chemical separation and analysis, specifically applied to the complex component systems such as traditional Chinese medicinal materials, and has potential industrial process and application value.

The invention relates to a gene nanoprobe for targeted lung cancer treatment as well as a preparation method and application thereof, and belongs to the technical field of biochemical nano materials.The gene nanoprobe for the targeted lung cancer treatment comprises an RNA nano hydrogel and DOX and / or TMPyP4 loaded on the RNA nano hydrogel; the RNA nano hydrogel comprises a DNA self-assembled single chain, a cyclization DNA template and a targeted aptamer. The gene nanoprobe has a strong specific recognition ability, precise targeting, small toxic and side effects, high killing and injuring intensity against lung cancer cells, good therapeutic effect, and great potential in the application of the lung cancer treatment.

The invention provides application of a cholesterol molecule imprinted membrane sensing electrode in detecting cholesterol content in blood. Specific steps in the method are as follows: (1) treating a blood sample, that is, standing the blood sample at room temperature and carrying out centrifugation to extract serum if the blood sample is obtained by drawing blood from a person who is on an empty stomach, or carrying out anticoagulation by using heparin or EDTA (ethylene diamine tetraacetic acid) if the blood sample is blood plasma; (2) dropwise adding the blood sample obtained in step (1) onto the cholesterol molecule imprinted membrane sensing electrode, inserting the cholesterol molecule imprinted membrane sensing electrode into an amperometric sensor for determination, and recording readings. When used for detecting cholesterol content in blood, the molecule imprinted membrane sensing electrode has the advantages of low cost, high sensitivity, fast analysis speed, capacity of reducing sampling amount and avoiding tedious pretreatment of blood samples, etc.