A method for preparing molecularly imprinted sensors by photocatalytic raft polymerization and its application

A molecular imprinting and sensor technology, which is applied in the field of photocatalytic RAFT polymerization to prepare molecularly imprinted sensors, can solve the problems of complex reaction conditions and cumbersome processes.

Active Publication Date: 2020-10-30
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If photocatalytic RAFT polymerization technology can be applied to the synthesis of molecularly imprinted polymers, it will solve the problems of cumbersome process and complicated reaction conditions in common methods.

Method used

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  • A method for preparing molecularly imprinted sensors by photocatalytic raft polymerization and its application
  • A method for preparing molecularly imprinted sensors by photocatalytic raft polymerization and its application
  • A method for preparing molecularly imprinted sensors by photocatalytic raft polymerization and its application

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Experimental program
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Effect test

Embodiment 1

[0031] Embodiment 1: the method for preparing melamine molecularly imprinted sensor

[0032] 1. The synthesis process of melamine-methacrylic acid (MAA) prepolymerization solution

[0033](1) 0.014g ruthenium terpyridyl was added to 25 mL of an aqueous solution of gold nanoparticles with a concentration of 1 mg / mL, reacted at room temperature for 15 minutes, and gold nanoparticles immobilized with ruthenium terpyridyl were obtained at a speed of 8000 rpm.

[0034] (2) 6.30 mg of melamine was completely dissolved in 20 mL of a mixed solution of ethanol and water (4:1 by volume), and then ultrasonicated for 10 minutes.

[0035] (3) Add 17.22 mg of MAA solution to the solution obtained in step (2), and react at 6° C. for 6 hours to obtain a prepolymer solution.

[0036] 2. Synthesis of cross-linked melamine-polymethacrylic acid (PMAA) polymer

[0037] (1) Add 0.198g of crosslinking agent ethylene glycol dimethacrylate and 0.26mg RAFT reagent (4-cyano-4-ethyl-trithiopentanoic ac...

Embodiment 2

[0045] Embodiment 2: the method for preparing melamine molecularly imprinted sensor

[0046] 1. The synthesis process of melamine-sodium p-styrenesulfonate prepolymerization liquid

[0047] (1) 0.045g ruthenium terpyridyl was added to 50mL of an aqueous solution of gold nanoparticles with a concentration of 12mg / mL, reacted at room temperature for 110 minutes, and obtained gold nanoparticles immobilized with ruthenium terpyridine at a speed of 5000 rpm.

[0048] (2) 8.50 mg of melamine was completely dissolved in 450 mL of a mixed solution of ethanol and water (4:1 by volume), and then ultrasonicated for 20 minutes.

[0049] (3) Add 25.03 mg of MAA solution to the solution obtained in step (2), and react at 12° C. for 10 hours to obtain a prepolymer solution.

[0050] 2. Synthesis of cross-linked melamine-polystyrene sodium polysulfonate polymer

[0051] (1) Add 0.312g of cross-linking agent orthosilicate ethyl ester and 1.55mg RAFT reagent (4-cyano-4-ethyl-trithiopentanoic ...

Embodiment 3

[0061] Example 3: A method for preparing a lincomycin molecularly imprinted sensor. The melamine in Example 1 was replaced by lincomycin. The other preparation methods were the same, and a sensor with excellent specific recognition ability for lincomycin was prepared. .

[0062] Using the same preparation method, using midecamycin, tropicamide, and erythromycin as template molecules, sensors with excellent specific recognition capabilities for midecamycin, tropicamide, and erythromycin were also prepared.

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Abstract

The invention belongs to the field of molecular imprinting sensor field, and more specifically relates to a method used for photocatalysis RAFT polymerization preparation of a molecular imprinting sensor. The method mainly comprises following steps: a compound containing a tertiary amine structure is taken as a template molecule, and a template molecule-functional monomer pre-polymerized solutionis synthesized; tris (bipyridine) ruthenium is taken as both as a photocatalyst and an electrochemiluminescence agent, photocatalysis RAFT polymerization is carried out, and synthesis of a molecular imprinting polymer with a structure and a size similar to those of the template molecule is realized; and at last, a molecular imprinting sensor is obtained. The molecular imprinting sensor is high inspecific identifying capacity, can be used for quantitative determination, and the lowest detection lower limit concentration reaches 1*10<-13>mol / L. According to the preparation method, no extra polymerization initiator is needed, the process is more simple, is high in efficiency, is green, and is friendly to the environment.

Description

technical field [0001] The invention belongs to the technical field of chemical synthesis, especially the field of molecularly imprinted sensors, and specifically relates to a method for preparing molecularly imprinted sensors by photocatalytic RAFT polymerization and its application. Background technique [0002] Molecular imprinting technology has the advantages of sensitive, simple, and cheap detection and analysis, and refers to the process of preparing polymers that are specifically selected for a certain or specific target molecule (or template molecule). Its molecular recognition principle is based on the formation of a highly cross-linked rigid molecularly imprinted polymer around the target molecule. After the target molecule is eluted, a rigid cavity is left in the polymer network structure, with and The shape of the substrate molecule matches and the functional groups arranged in a certain order, so it has a very high selective recognition of the target molecule. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/64G01N27/30
CPCG01N21/6428G01N27/30
Inventor 刘敬权陈涛蔡金涛
Owner QINGDAO UNIV
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