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Preparation method and application of molecularly imprinted photonic crystal for detecting sulfamethoxazole

A sulfamethoxazole, photonic crystal technology, applied in material analysis, measurement device, analysis material and other directions by observing the impact on chemical indicators, can solve the problem of accelerating the evolution and spread of drug-resistant bacteria, destroying ecological balance, and human health. Threats and other issues, to achieve the effect of strong specific identification, accurate quantitative determination, and low detection limit

Inactive Publication Date: 2021-06-15
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, a large number of antibiotics enter natural water bodies along with wastewater and agricultural waste, which accelerates the evolution and spread of drug-resistant bacteria, destroys the ecological balance, and poses a serious threat to human health.
The antibiotics currently used are mainly amides, macrolides, tetracyclines and sulfonamides, among which sulfamethoxazole is the most widely used sulfonamides, and its chemical properties are stable and not easy to degrade

Method used

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  • Preparation method and application of molecularly imprinted photonic crystal for detecting sulfamethoxazole
  • Preparation method and application of molecularly imprinted photonic crystal for detecting sulfamethoxazole

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] 1. Preparation of precursor solution

[0045] Weigh 0.01g of sulfamethoxazole, 1.35g of acrylic acid, 1.35g of acrylamide, 1.90g of 2-vinylpyridine, and 0.01g of N,N'-methylenebisacrylamide into a 50mL centrifuge tube, then add 5.4g of distilled water , after fully dissolving, 0.013 g of azobisisobutylimidazoline hydrochloride was added. Nitrogen was bubbled through the solution for 10 minutes. Store the prepared precursor solution in a cool and dark place for future use.

[0046] 2. Preparation of photonic crystal template

[0047] First, fix the clean glass slide vertically in a 150mL beaker, then slowly pour 20mL of polystyrene emulsion with a solid content of 1.5% and a particle size of 725nm along the wall of the beaker. Then place the beaker in a constant temperature water bath at 43°C until the water evaporates completely, then transfer the beaker to a vacuum oven at 80°C and bake for 1 hour. Finally, another clean slide glass is used to cover the surface of ...

Embodiment 2

[0053] 1. Preparation of precursor solution

[0054] Weigh 0.01g of sulfamethoxazole, 1.50g of acrylic acid, 1.35g of acrylamide, 2.05g of 2-vinylpyridine, and 0.02g of N,N'-methylenebisacrylamide into a 50mL centrifuge tube, then add 5.1g of distilled water , after fully dissolving, add 0.015 g of azobisisobutylimidazoline hydrochloride. Nitrogen was bubbled through the solution for 10 minutes. Store the prepared precursor solution in a cool and dark place for future use.

[0055] 2. Preparation of photonic crystal template

[0056] First, fix the clean glass slide vertically in a 150mL beaker, then slowly pour 20mL of polystyrene milk with a solid content of 3% and a particle size of 550nm along the wall of the beaker. Then place the beaker in a constant temperature water bath at 43°C until the water evaporates completely, then transfer the beaker to a vacuum oven at 80°C and bake for 1 hour. Finally, another clean slide glass is used to cover the surface of the photonic...

Embodiment 3

[0062] 1. Preparation of precursor solution

[0063] Weigh 0.015g of sulfamethoxazole, 1.45g of acrylic acid, 1.45g of acrylamide, 2.00g of 2-vinylpyridine, and 0.02g of N,N'-methylenebisacrylamide into a 50mL centrifuge tube, then add 5.1g of distilled water , after fully dissolving, 0.012 g of azobisisobutylimidazoline hydrochloride was added. Nitrogen was bubbled through the solution for 10 minutes. Store the prepared precursor solution in a cool and dark place for future use.

[0064] 2. Preparation of photonic crystal template

[0065] First, fix the clean glass slide vertically in a 150mL beaker, then slowly pour 20mL of polystyrene emulsion with a solid content of 2% and a particle size of 450nm along the wall of the beaker. Then place the beaker in a constant temperature water bath at 43°C until the water evaporates completely, then transfer the beaker to a vacuum oven at 80°C and bake for 1 hour. Finally, another clean slide glass is used to cover the surface of t...

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Abstract

The invention discloses a preparation method and application of a molecularly imprinted photonic crystal for detecting sulfamethoxazole. The preparation method comprises the following steps of firstly, depositing polystyrene emulsion microspheres on the surface of a glass slide by utilizing a vertical deposition method to obtain a photonic crystal template, filling gaps of the polystyrene microspheres on the photonic crystal template with a precursor solution containing sulfamethoxazole, a functional monomer, a cross-linking agent and an initiator, carrying out a constant temperature reaction for a period of time, and eluting the polystyrene microspheres and sulfamethoxazole with a solvent to prepare the molecularly imprinted photonic crystal. The molecularly imprinted photonic crystal provided by the invention shows different colors in sulfamethoxazole solutions with different concentrations, and the concentration range of sulfamethoxazole can be roughly judged through naked eye observation. Furthermore, the displacement of the Bragg diffraction peak of the photonic crystal is measured by using a fiber optic spectrometer, so that quantitative analysis on trace sulfamethoxazole can be realized.

Description

technical field [0001] The invention relates to the technical field of antibiotic detection, in particular to a method for preparing a molecularly imprinted photonic crystal for detecting sulfamethoxazole and its application. Background technique [0002] Antibiotics are a class of antibacterial drugs used to treat or prevent bacterial infections, and their widespread use has played an important role in promoting the development of modern medicine and agriculture. However, a large number of antibiotics enter natural water bodies along with wastewater and agricultural waste, which accelerates the evolution and spread of drug-resistant bacteria, destroys the ecological balance, and poses a serious threat to human health. The currently used antibiotics are mainly amides, macrolides, tetracyclines and sulfonamides, among which sulfamethoxazole is the most widely used sulfonamides, and its chemical properties are stable and not easy to degrade. Sulfamethoxazole pollution has app...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/47G01N21/78
CPCG01N21/4788G01N21/78
Inventor 余莉萍南境王滨
Owner TIANJIN UNIV
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