Preparation method and application of molecularly imprinted photonic crystal for detecting sulphaguanidine

A technology of photonic crystals and molecular imprinting, applied in the direction of material analysis, measuring devices, and analytical materials through observation of the impact on chemical indicators, can solve the problem of destroying ecological balance, accelerating the evolution and spread of drug-resistant bacteria, threats to human health, etc. problem, to achieve the effect of large specific surface area and strong specific recognition effect

Inactive Publication Date: 2021-06-25
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, a large number of antibiotics enter natural water bodies along with agricultural wastewater, which accelerates the evolution and spread of drug-resistant bacteria, destroys the ecological balance, and poses a serious threat to human health.

Method used

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  • Preparation method and application of molecularly imprinted photonic crystal for detecting sulphaguanidine
  • Preparation method and application of molecularly imprinted photonic crystal for detecting sulphaguanidine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Add 0.02g of sulfamidine, 1.20g of acrylamide, 1.2g of methacrylic acid, 1.60g of 4-vinylpyridine, 0.01g of N,N'-methylenebisacrylamide, 0.015g of 2,2'-nitrogen into a 50mL centrifuge tube Heterobis(2-imidazoline) dihydrochloride and 6 g of water were stirred and dissolved evenly, and nitrogen gas was passed for 20 minutes to prepare a precursor solution.

[0045] Fix a clean glass slide vertically in a 150mL beaker, then slowly pour 50mL of polystyrene microspheres with a solid content of 1.5% and a particle size of 625nm into the flask, and then transfer the beaker to a constant temperature water bath at 45°C , kept warm for 48 hours, then transferred the beaker to a 75°C oven and baked for 1 hour, and finally covered another glass slide on the surface of the photonic crystal, and fixed the two slides with adhesive tape to prepare a photonic crystal template.

[0046] Drop 2.0mL of the precursor solution onto the upper edge of the photonic crystal template glass slide...

Embodiment 2

[0049] Add 0.017g sulfamidine, 1.05g acrylamide, 1.15g methacrylic acid, 1.50g 4-vinylpyridine, 0.015g N,N'-methylene bisacrylamide, 0.015g 2,2'- Azabis(2-imidazoline) dihydrochloride and 6.3 g of water were stirred and dissolved evenly, and nitrogen gas was passed for 20 minutes to prepare a precursor solution.

[0050] Fix a clean glass slide vertically in a 150mL beaker, then slowly pour 50mL of polystyrene microspheres with a solid content of 2.0% and a particle size of 525nm into the flask, and then transfer the beaker to a constant temperature water bath at 45°C , keep warm for 48 hours, then transfer the beaker to a 75°C oven for 1 hour, and finally cover another glass slide on the surface of the photonic crystal, and fix the two slides with adhesive tape to prepare a photonic crystal template.

[0051] Drop 2.0mL of the precursor solution onto the upper edge of the photonic crystal template glass slide, tilt the glass slide slightly, and let it stand to make the precur...

Embodiment 3

[0054] Add 0.025g of sulfamidine, 1.35g of acrylamide, 1.15g of methacrylic acid, 1.80g of 4-vinylpyridine, 0.01g of N,N'-methylenebisacrylamide, 0.015g of 2,2'- Azabis(2-imidazoline) dihydrochloride and 5.7 g of water were stirred and dissolved evenly, and nitrogen gas was passed for 20 minutes to prepare a precursor solution.

[0055] Fix a clean glass slide vertically in a 150mL beaker, then slowly pour 50mL of polystyrene microspheres with a solid content of 2.5% and a particle size of 575nm into the flask, and then transfer the beaker to a constant temperature water bath at 45°C , keep warm for 48 hours, then transfer the beaker to a 75°C oven for 1 hour, and finally cover another glass slide on the surface of the photonic crystal, and fix the two slides with adhesive tape to prepare a photonic crystal template.

[0056] Drop 2.0mL of the precursor solution onto the upper edge of the photonic crystal template glass slide, tilt the glass slide slightly, and let it stand to...

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Abstract

The invention discloses a preparation method and application of a molecularly imprinted photonic crystal for detecting sulphaguanidine. The preparation method comprises the following steps: firstly, uniformly depositing polystyrene microspheres with a certain size on the surface of a glass slide by utilizing a vertical deposition method to form a photonic crystal template; then filling gaps of polystyrene microspheres of the photonic crystal template with a precursor solution containing imprinted molecules, a functional monomer, a cross-linking agent and an initiator under the action of capillary force, and after a thermal initiation polymerization reaction, removing the polystyrene microspheres and the imprinted molecules in sequence by using an eluent to obtain the molecularly imprinted photonic crystal with an inverse opal structure. The obtained molecularly imprinted photonic crystal shows different structural colors when placed in sulphaguanidine solutions with different concentrations, the concentration range of the sulphaguanidine solutions can be judged through naked eye observation, the Bragg diffraction peak displacement of the molecularly imprinted photonic crystal is further measured through a fiber optic spectrometer, and quantitative measurement of trace sulphaguanidine can be achieved.

Description

technical field [0001] The invention relates to the technical field of antibiotic detection, in particular to a preparation method and application of a molecularly imprinted photonic crystal for detecting sulfamidine. Background technique [0002] Sulfonamide antibiotics are a class of artificially synthesized antibacterial drugs with p-aminobenzenesulfonamide as the main structure. They have high stability, broad-spectrum antibacterial properties and low prices, so they are widely used in modern agriculture. However, a large number of antibiotics enter natural water bodies along with agricultural wastewater, which accelerates the evolution and spread of drug-resistant bacteria, destroys the ecological balance, and poses a serious threat to human health. Sulfaamidine is a large amount of sulfa antibiotics, and it is not easy to degrade. At present, sulfamidine pollution has appeared in many natural water bodies. Therefore, the establishment of an analytical and detection me...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/47G01N21/78
CPCG01N21/4788G01N21/78
Inventor 余莉萍南境王滨
Owner TIANJIN UNIV
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