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Surface modification method of biomaterial magnesium alloy

A technology of surface modification and magnesium alloys, applied in the field of surface modification of medical magnesium alloys, can solve the problems of difficult magnesium alloys such as physiological corrosion resistance, blood compatibility endothelial cell growth performance, etc., and achieve excellent blood compatibility , Excellent effect of promoting endothelial healing and improving physiological corrosion resistance

Active Publication Date: 2017-09-22
HUAIYIN INSTITUTE OF TECHNOLOGY
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Problems solved by technology

The current surface modification methods mainly include surface chemical treatment, surface alloying, surface heat treatment, micro-arc oxidation, anodic oxidation, preparation of surface coating, plasma treatment, etc., but these methods are difficult to simultaneously improve the physiological corrosion resistance of magnesium alloys. properties, hemocompatibility, and endothelial growth-stimulating properties

Method used

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  • Surface modification method of biomaterial magnesium alloy
  • Surface modification method of biomaterial magnesium alloy
  • Surface modification method of biomaterial magnesium alloy

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Embodiment Construction

[0037] Such as figure 1 As can be seen, the present invention comprises the following steps:

[0038] 1) First, carry out surface chemical treatment on the surface of the magnesium alloy;

[0039] 2) Then self-assemble and fix aminosilane molecules on the surface of the chemically treated magnesium alloy;

[0040] 3) Finally, polyethylene glycol, fibronectin, and heparin were immobilized on the surface of the material in turn, and there were many magnesium alloy biomaterials with good corrosion resistance and multifunctional bioactivity.

[0041] In the step 1), the surface chemical treatment method is:

[0042] 1.1) Polish and clean the magnesium alloy;

[0043] 1.2) The polished and cleaned magnesium alloy was immersed in a mixed solution of sodium hydroxide and sodium phosphate at a temperature of 75°C for 40 minutes.

[0044] In the step 1.2), the concentration of NaOH in the mixed solution of sodium hydroxide and sodium phosphate is 30 g / L, and NaOH 3 PO 4 12H 2 Th...

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Abstract

The invention discloses a surface modification method of a biomaterial magnesium alloy. The method comprises, firstly, performing surface chemical treatment on the surface magnesium alloy; secondly, self-assembling and immobilizing amino silane molecules; lastly, sequentially immobilizing polyethylene glycol, fibronectin and heparin on the surface to structure a multifunctional bioactive surface and meanwhile to improve the physiological corrosion-resistant performance of the magnesium alloy. Through surface modification of the biomaterial magnesium alloy, the method can improve the physiological corrosion-resistant performance of the magnesium alloy and endow the material with good blood compatibility and endothelial cell growth promoting property, thereby laying a good foundation for application of the biomaterial magnesium alloy to the fields of intravascular implantation of materials or devices such as intravascular stents.

Description

technical field [0001] The invention relates to the technical field of biological materials, in particular to a method for surface modification of medical magnesium alloys. Background technique [0002] Coronary atherosclerotic heart disease (often abbreviated as coronary heart disease) is a heart disease in which atherosclerotic lesions in the coronary arteries cause stenosis or blockage of the vascular lumen, resulting in myocardial ischemia, hypoxia or necrosis. Vascular stent implantation is currently the main clinical method for treating coronary heart disease caused by vascular stenosis. At present, the materials used for the preparation of vascular stents mainly include stainless steel, nickel-titanium alloy, cobalt-chromium alloy, platinum-iridium alloy, etc., but these materials are inert materials, and will remain permanently in the body as foreign bodies after implantation, which will cause inflammation to varying degrees , thrombosis, vascular intimal hyperplasi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/14A61L31/02A61L31/16A61L31/08A61L31/12A61L31/10A61L33/00A61L33/08C23C22/60
CPCA61L31/022A61L31/08A61L31/10A61L31/14A61L31/16A61L33/0011A61L33/08A61L2300/236A61L2300/252A61L2300/412A61L2300/42C23C22/60C08L71/02C08L5/10C08L89/00
Inventor 潘长江张瑜杰丁红燕刘涛龚韬王亚楠
Owner HUAIYIN INSTITUTE OF TECHNOLOGY
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