The invention discloses a pain-relieving plaster which is prepared by pain-relieving powder and a medical plaster body, wherein the pain-relieving powder is prepared by the following raw materials in percentage by weight: 50-60 percent of Chinese medicinal materials A, 20-40 percent of Chinese medicinal materials B and 10-30 percent of Chinese medicinal materials C, the Chinese medicinal materials A comprise one or a plurality of saffron, radix linderae, radix aucklandiae, radix clematidis, frankincense, myrrh, clove, muskiness, fennel, cinnamon, radix angelicae tuhuo, radix ampelopsis, peachkernel, semen brassicae, golden cypress, camphor, scorpio, pangolin and ground beetle; the Chinese medicinal materials B comprise one or a plurality of rhododendron molle, tuberose, hindu datura flower, monkshood, radix aconite agrestis, rhizoma arisaematis, rhizoma typhonii, dysosma chengii(Chien) Keng f., common threewingnut root and scopolia acutangula; and the Chinese medicinal materials C comprise one or a plurality of buttercup, rhizoma typhonii flagelliformis, myriogyne minuta, garlic, cantharis and croton seed. The pain-relieving plaster is prepared by a plurality of Chinese medicinalmaterials, can effectively rapidly treat diseases of rheumatoid disease, gout, cervical spondylosis, lumbar interveterbral disc protrusion, and the like, and have simple preparation method.