New-type of inorganic bone grafting material and its preparation and use

A bone implant and inorganic technology, applied in the field of new inorganic bone graft materials and composite artificial inorganic bone cement, can solve the problems of fast absorption, soft tissue packing, slow dissolution and absorption, etc., to achieve convenient storage and use, good bone defect repair, Simple preparation process

Inactive Publication Date: 2009-09-09
GENERAL HOSPITAL OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the results of clinical application of calcium sulfate vary greatly. The main reason is that the calcium sulfate used is different in size and crystal structure, resulting in too fast absorption in the body after filling bone defects, and it is completely absorbed before new bone formation, resulting in Cavities in the bone defect or filled with soft tissue
The crystal structure of calcium sulfate hemihydrate is controlled through a series of special processes to form a neat and consistent α-type crystal structure, which has relatively slow dissolution and absorption. Medical grade calcium sulfate (Osteoset) was approved by FDA for clinical use in 1996, including two specifications. The tablet granules (4.8×3.3mm, 3×2.5mm) are mainly used to fill various inclusive bone defects, but the integrity of the tablet granules must be maintained, otherwise it will affect its absorption speed and bone defect repair effect
However, its brittle characteristics and lack of mechanical strength limit its wide application in clinic, and further improvement in mechanical and biological properties is needed to improve its clinical effect.

Method used

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  • New-type of inorganic bone grafting material and its preparation and use
  • New-type of inorganic bone grafting material and its preparation and use
  • New-type of inorganic bone grafting material and its preparation and use

Examples

Experimental program
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Effect test

Embodiment 1

[0038] 1. Preparation of β-tricalcium phosphate particles with a microporous structure: take healthy bovine cancellous bone and crush it into particles with a diameter of 2-3mm, rinse it and calcinate it in a high-temperature furnace at 800°C for 3 hours, take it out and soak it in a concentration of 1M of (NH 4 ) 2 HPO 4 Put in the solution for 24 hours, dry at 50°C for 4 days, put it in a high-temperature calciner at 1100°C for 1 hour, heat up at a rate of 5°C / min, slowly cool down, rinse with deionized water twice, and dry at 50°C for 4 days to prepare The main ingredient is granules of β-tricalcium phosphate. The pellets have been stripped of organic matter. The diameter of the particles was 4 mm.

[0039] 2. Preparation of α-calcium sulfate hemihydrate powder: put analytically pure calcium sulfate dihydrate in a closed high-pressure reactor with a steam pressure of 0.13Mpa and heat it to 123°C, heat it at a constant temperature for 7 hours, and then take out the elect...

Embodiment 2

[0042] 1. Preparation of β-tricalcium phosphate particles with a microporous structure: take healthy bovine cancellous bone and crush it into particles with a diameter of 2-3mm, rinse it and calcinate it in a high-temperature furnace at 800°C for 3 hours, take it out and soak it in a concentration of 1M of (NH 4 ) 2 HPO 4 Put in the solution for 24 hours, dry at 50°C for 4 days, put it in a high-temperature calciner at 1100°C for 1 hour, heat up at a rate of 5°C / min, slowly cool down, rinse with deionized water twice, and dry at 50°C for 4 days to prepare The main ingredient is granules of β-tricalcium phosphate. The pellets have been stripped of organic matter. The diameter of the particles was 10 mm.

[0043] 2. Preparation of α-calcium sulfate hemihydrate powder: put analytically pure calcium sulfate dihydrate in a closed high-pressure reactor with a steam pressure of 0.13Mpa and heat it to 123°C, heat it at a constant temperature for 7 hours, and then take out the elec...

Embodiment 3

[0046] 1. Preparation of β-tricalcium phosphate particles with a microporous structure: 2 parts by weight of calcium hydrogen phosphate was converted into calcium pyrophosphate at 800°C for 3 hours, then mixed with 1 part by weight of calcium carbonate and pressed into tablets, 1100 After 1 hour under the condition of ℃, cool slowly, and make β-tricalcium phosphate powder after pulverization, and adopt microporous foaming technology (conventional method) to make β-tricalcium phosphate particles with microporous structure. The diameter of the particles is 0.2 mm.

[0047] 2. Preparation of α-calcium sulfate hemihydrate powder: put analytically pure calcium sulfate dihydrate in a closed high-pressure reactor with a steam pressure of 0.13Mpa and heat it to 123°C, heat it at a constant temperature for 7 hours, and then take out the electric heating ventilator placed at 120°C Dry in a drying oven for 4-5 hours, and crush the obtained material into α-sulphuric acid hemihydrate powde...

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Abstract

The invention discloses a novel inorganic bone graft material, which belongs to the field of medical materials. A new type of inorganic bone graft material, which is composed of β-tricalcium phosphate particles with a mass percentage of 20%-80% and α-calcium sulfate hemihydrate powder with a mass percentage of 80%-20%. A layered structure is formed on the surface of β-tricalcium phosphate particles and / or inside their pores. The advantages of the present invention are: based on the excellent biocompatibility and in vivo degradation performance of α-calcium sulfate hemihydrate and β-tricalcium phosphate, the composite artificial bone particles with self-curing properties can repair bone defects of any shape, In-situ solidification and rapid restoration of bone mechanical strength. With the rapid degradation of calcium sulfate in the body, β-tricalcium phosphate particles with microporous structure provide an ideal scaffold for new bone growth, and can be gradually replaced by new bone crawling. The composite artificial bone has wide sources, convenient storage and use, excellent performance, simple preparation process, easy use, short preparation period and low cost.

Description

technical field [0001] The present invention relates to a new type of inorganic bone graft material, its preparation method and application, in particular to a self-curing and absorbable composite artificial inorganic bone cement used in medical surgery for replacing and repairing bone tissue defects, its preparation method and The invention belongs to the field of medical materials. Background technique [0002] Bone is composed of inorganic components and organic components, of which the inorganic components account for 60-70% of the dry weight, and the main component is hydroxyapatite (Ca 10 (PO 4 ) 6 ·5H 2 O) and a small amount of sodium salt, magnesium salt, etc., the organic component is mainly type I collagen. The size of the hydroxyapatite crystal is about 25-50nm×40nm×200-350nm, and the direction of the long axis (c-axis) of the crystal is consistent with the direction of the type I collagen fiber, forming a porous structure material with interconnected micropor...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/42A61L27/12A61L27/54
Inventor 毛克亚王岩侯喜君梁茂华
Owner GENERAL HOSPITAL OF PLA
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