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Medicine for increasing immunocompetence of children and its preparing process

A technology of immunity and drugs, applied in the direction of drug combinations, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve the problems of serious side effects, adverse reactions, poor curative effect, etc., shorten the course of disease, improve cold resistance, good The effect of curative effect

Active Publication Date: 2004-11-10
广州康和药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The simple application of immunomodulators or nutritional enhancers is likely to cause other secondary diseases, serious side effects and adverse reactions to children with body cold
Current Chinese patent medicines are not effective

Method used

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  • Medicine for increasing immunocompetence of children and its preparing process
  • Medicine for increasing immunocompetence of children and its preparing process
  • Medicine for increasing immunocompetence of children and its preparing process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1 is the preparation method of Chinese medicine tablet of the present invention:

[0022] (A) Take 80.5 grams of yam and 6.5 grams of orange peel, wash them, and grind them into fine powder for later use;

[0023] (B) Take 80.5 grams of oysters, 80.5 grams of Astragalus membranaceus, add water and decoct twice, the first time for 2 hours, the second time for 1.5 hours, let it cool, and filter;

[0024] (C) Take 53.5 grams of Atractylodes macrocephala and 27 grams of Fangfeng to collect volatile oil by steam distillation for later use, add water to decoct the medicinal residues for 1.5 hours, let cool, and filter;

[0025] (D) Merge the filtrates of items B and C, condense into a thick paste, add 2 / 3 yam powder and full amount of tangerine peel powder in step A and mix evenly, dry, pulverize into fine powder, add auxiliary materials and correctives and mix evenly, and prepare Granules and drying, the unleashed oil in step C is dissolved with an appropriate am...

Embodiment 2

[0029] Embodiment 2 is a pharmacological test of the present invention.

[0030] 1. Acute toxicity test

[0031] Select 13 healthy mice of 18 to 22 grams, male or female, and administer them orally at a dose of 16g / Kg body weight, which is equivalent to 572 times the clinical dose. After 72 hours of observation, none of the animals died or had any adverse reactions. .

[0032] 2, the influence of Chinese medicine tablet of the present invention on phagocytic function

[0033] (1) Effects on the clearance rate of colloidal carbon particles in mouse plasma:

[0034] Get 29 healthy mice with a body weight of 17 to 22 grams, male or female, and divide them into two groups at random, wherein the water for injection group presses 0.2ml / 10g body weight, and the Chinese medicine tablet group of the present invention presses 14mg / 10g body weight for intragastric administration once a day, continuously 12 days. On the 12th day, 24ml / 10g body weight mice were injected with Indian ink...

Embodiment 3

[0050] Embodiment 3 is clinical trial data.

[0051] Gender: 88 males and 77 females, a total of 165 cases. The male to female ratio was 1.14:1.

[0052] Age: The youngest was 9 months and the oldest was 12 years old; 32 cases were under 3 years old, 103 cases were 3-5 years old, and 30 cases were >5 years old.

[0053] All cases had a history of recurrent respiratory tract infection with varying times. 165 cases of frail children belonged to deficiency of lung qi or deficiency of both lung and spleen according to TCM syndrome differentiation, among which 76 cases were of deficiency of lung qi, accounting for 46.1%, and 89 cases were of deficiency of both lung and spleen, accounting for 53.9%. The main clinical symptoms are shown in Table 5:

[0054] table 5

[0055]

[0056] Blood routine examination: minimum hemoglobin 8.3g, maximum 14.1g; red blood cell count minimum 2.62 million, maximum 4.24 million; white blood cell count minimum ...

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Abstract

The invention discloses a medicament for enhancing children's immunocompetence which comprises the following constituents with parts by weight, astragalus root 75-85, dried orange peel 5.5-7, white atractylodes rhizome 50-60, Chinese yam 75-85, ledebouriella root 22-32, oyster 75-85. The traditional Chinese composition according to the invention has the function of improving body immunocompetence. The invention also discloses the process for preparing the medicament.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to an immune-enhancing traditional Chinese medicine composition. Background technique [0002] According to incomplete statistics from the United Nations Children's Fund, about 14 million children under the age of 5 die every year in developing countries due to physical weakness and malnutrition. These children have the disease basis of poor immunity, weak disease resistance, and low digestive function. The simple application of immunomodulators or nutritional enhancers is likely to bring other secondary diseases, serious side effects and adverse reactions to children with body cold. The curative effect of Chinese patent medicine is not good enough at present. Contents of the invention [0003] The object of the present invention is to provide a medicine for strengthening the lungs and strengthening the exterior, invigorating the spleen and stomach, improving the imm...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K35/618A61P37/04
Inventor 黄漫翔
Owner 广州康和药业有限公司
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