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Pharmaceutical composition for resisting herpes simplex virus and its preparing process

A herpes simplex virus and composition technology, applied in the directions of drug combination, antiviral agent, drug delivery, etc., can solve the problems of no approved effective treatment method, slow effect, easy to delay the disease, etc., to inhibit damage, promote repair, shorten effect of disease course

Inactive Publication Date: 2005-09-07
HANGHZOU HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] But above-mentioned traditional Chinese medicine decoction all has the shortcoming that takes effect slowly, easily delays disease state
Moreover, there are still no recognized effective treatment methods and anti-HSV Chinese medicine preparations that have entered the market with effective drugs, such as eye drops preparations, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] (a) Take the following Chinese medicinal materials as raw materials:

[0043] Coptidis 6kg, Gentiana 6kg, Gujingcao 5kg, Borneol 0.1kg.

[0044] (b) add 36L, 0.5% hydrochloric acid solution decocting 6kg of Rhizoma Coptidis twice, decocting time for the first time is 1.5 hours, add 30L, 0.5% hydrochloric acid solution decocting for the second time, decocting time is After 1 hour, the decoction was filtered, and the filtrate was concentrated under reduced pressure into extract A with a relative density of about 1.12 (20°C).

[0045] Add water to decoct 6kg of gentian and 5kg of Gujingcao twice, the first decoction time is 1 hour, filter out the decoction, add water to the medicine dregs, and decoct the second time for 0.5 hours, add water each time It is advisable to cover the surface without the medicine, filter the decoction, and concentrate the filtrate under reduced pressure to become an extract B with a relative density of about 1.12 (20°C).

[0046] (c) Combine t...

Embodiment 2

[0049] (a) Weigh raw materials: Coptis 4kg, Gentiana 4kg, Borneol 0.05kg, Houttuynia cordata 4kg, white chrysanthemum 4kg

[0050] (b) Extract aromatic water from 4 kg of Houttuynia cordata and 4 kg of white chrysanthemum, and the amount of aromatic water taken is 20 L.

[0051] Coptidis 4kg is decocted with 0.5% 24L hydrochloric acid solution, the first decoction time is 1.5 hours, filter out the decoction, add 20L hydrochloric acid solution to the medicinal residue and decoct the second time for 1 hour, filter the decoction, and decompress the filtrate Concentrate into extract A with a relative density of about 1.12 at 20°C.

[0052] Take 4 kg of gentian and add water to decoct twice. The amount of water added is suitable for immersing the medicinal noodles. The first decoction time is 1 hour, and the decoction is filtered out. The decoction is decocted for 0.5 hours for the second time. When concentrated to 20°C, the relative density is about 1.12 extract B.

[0053] (c) ...

Embodiment 3

[0056] (a) Take the following Chinese herbal medicines as raw materials:

[0057] Coptidis 8kg Gentiana 8kg Borneol 0.2kg Gardenia 8kg Wild Chrysanthemum 8kg Chanyi 8kg

[0058] (b) 8 kg of wild chrysanthemum flowers extract aromatic water, and the amount of aromatic water is 25 L.

[0059] Get Coptidis 8kg and decoct with 48L concentration of 6% acetic acid, the first decoction time is 1.5 hours, filter out the decoction, and decoct the dregs for the second time for 1 hour, the filtrate is concentrated under reduced pressure, and the relative density is about 1.12 ( 20°C) concentrated extract.

[0060] Gentiana 8kg, Gardenia 8kg, Cicada 8kg are decocted with water, and the amount of water added each time is suitable for immersing the surface of the medicine. The decoction time is 1 hour, and the decoction is filtered out. hour, the decoction was filtered, and the filtrate was concentrated under reduced pressure into extract A with a relative density of about 1.12 (20°C).

...

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Abstract

The invention discloses a pharmaceutical composition for resisting herpes simplex virus and its preparing process, wherein the composition is prepared from coptis root, gentian root, pipewort, baras camphor by a predetermined weight ratio, the obtained active constituent has the actions of reducing fever, purging the intense heat and detoxicating. The composition can be prepared into eye drops, nose spray and electuary.

Description

technical field [0001] The invention relates to an anti-herpes simplex virus pharmaceutical composition and a preparation method thereof, belonging to the technical field of traditional Chinese medicines and manufacture. Background technique [0002] Herpes simplex virus (HSV for short) invades the body through oral cavity, respiratory tract, reproductive tract mucosa and skin damage, etc., and can hide in the ganglion cells of the trigeminal ganglion, in the corneal cells, or on the surface of the skin and mucosa. Herpers simplex keratitis (HSK for short) caused by HSV infection is one of the most serious viral infectious eye diseases in the world today. The interaction of link factors causes the transparent cornea to be replaced by a large number of new blood vessels and scar tissue, and the secondary uveitis, glaucoma, bacterial or fungal infection contributes to the deterioration of the condition, seriously endangers the visual function, and even ca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61P27/02A61P31/22
Inventor 钟良玉陈红梅
Owner HANGHZOU HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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