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Curcumin-containing pharmaceutical composition

A composition and technology of curcumin, applied in the field of medicine, can solve the problems of unfavorable clinical use of preparations, etc., and achieve effects suitable for wide clinical application, good therapeutic effect, and quality control

Inactive Publication Date: 2014-03-05
明远药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, there are many subtypes of HPV, and each subtype is different in virus phenotype, growth characteristics, pathogenicity, sensitivity to drugs, and clinical prognosis. Therefore, a single component cannot be effective for all subtypes, so a single component Preparations are not conducive to clinical use

Method used

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  • Curcumin-containing pharmaceutical composition
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0132] prescription:

[0133]

[0134] Dosage Form: Lotion

[0135] Preparation method: Take 70g of borneol, add appropriate amount of water to dissolve it; mix the prescribed amount of curcumin, turmeric volatile oil, curcumone, and curcumin with 50g of laurozone, 20g of polysorbate 80, and 80g of carbomer, and add 600g propylene glycol, 600g glycerol, stir well, add 200g lactic acid, stir well, add 1g chlorhexidine gluconate, stir well, add purified water to 10kg, stir well, sub-package, get concentrated solution, add water to dilute 10kg times use.

Embodiment 2-8

[0137] Prepare the lotion according to the following prescription, and the preparation method is the same as in Example 1.

[0138]

Embodiment 9

[0140] Prescription: Curcumin 6.5g, turmeric volatile oil 13.2g, curcumone 12.1g, curcumin 9.5g, borneol 3.5g.

[0141] Dosage form: effervescent tablet.

[0142] Preparation:

[0143] 1) Take β-cyclodextrin, add an appropriate amount of water according to 25ml / g, stir to make it completely dissolved, and heat it if necessary to obtain a β-cyclodextrin solution; curcumin, turmeric volatile oil, turmeric ketone, and curcuminol in the prescribed amount, Borneol, diluted with absolute ethanol, slowly added to the β-cyclodextrin solution, continued to stir until a homogeneous phase was formed, placed in the refrigerator overnight, filtered with suction, washed 3 times with a small amount of petroleum ether, and frozen to obtain a white powder.

[0144] 2) Mix the above-mentioned white powder with 3.5g of borneol, 150g of citric acid and 160g of lactose; take another 120g of sodium bicarbonate and 160g of lactose, mix them evenly, and use 5% PVP absolute ethanol solution as a bind...

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Abstract

The invention belongs to the technical field of medicines and provides a curcumin-containing pharmaceutical composition containing curcumin, volatile oil of curcuma longa, turmerone, curcumol and borneol. The pharmaceutical composition is definite in component and controllable in quality, can be used for preparing a vaginal administration preparation, a rectal administration preparation or an oral mucosal administration preparation, has favorable treating or preventing effect for HR-HPV (High Risk-Human Pappilomavirus) or LR-HPV (Low Risk-Human Pappilomavirus), cervical diseases (cervical intraepithelial neoplasia and carcinoma of uterine cervix), vulvar cancer, anal carcinoma, rectal cancer, oral cancer, verruca acuminate, verruca vulgaris, verruca plana, verruca plantaris and the like and is suitable for wide clinic application.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition comprising curcumin, turmeric volatile oil, curcumone, curcuminol and borneol. Background technique [0002] Human papillomavirus (HPV) is a kind of papillomavacuolating virus A belonging to Papovaviridae. It is a spherical DNA virus that can cause squamous epithelial proliferation of human skin and mucous membranes. At present, more than 130 kinds have been isolated, and different subtypes cause different clinical manifestations and invade different tissue parts. According to the classification of cancer, it can be divided into low-risk HPV (LR-HPV) and high-risk HPV (HR-HPV). HPV has strong resistance and can withstand drying and long-term storage. It can be inactivated by heating or treated with formalin, so it can be inactivated by high-temperature disinfection and 2% glutaraldehyde disinfection. HPV mainly includes 13 subtypes, whi...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61P31/20A61P17/12A61P35/00A61K31/045A61K31/12
Inventor 符耿哲康晓飞
Owner 明远药业有限公司
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