Preservative-free compositions comprising a complex of a corticosteroid and hpbcd for the treatment or prevention of an inflammatory disease through nasal administration

A preservative-free nasal spray composition using HPBCD and a corticosteroid addresses the challenge of maintaining stability and shelf life, providing effective treatment for nasal inflammations without the need for preservatives by utilizing HPBCD as a stabilizer, ensuring effective treatment or prevention of inflammatory diseases through nasal administration.

WO2024251923A1PCT designated stage expired Publication Date: 2024-12-12AQUILON PHARMA
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Patent Information

Application Number
PCT/EP2024/065683
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Priority Date
2023-06-07
Filing Date
2024-06-06
Publication Date
2024-12-12

AI Technical Summary

Technical Problem

There is a need for an efficient treatment of nasal inflammations that maintains sufficient shelf life without the need for preservatives, as existing nasal sprays often require preservatives to ensure sterility and stability.

Method used

A preservative-free liquid composition comprising a complex of hydroxypropyl-beta-cyclodextrin (HPBCD) and a corticosteroid, which improves shelf life and stability, allowing for aseptic filtration and long-term storage without the need for preservatives.

Benefits of technology

The HPBCD acts as a stabilizer, maintaining microbiological stability similar to preservative-based formulations, eliminating the need for preservatives and ensuring effective treatment or prevention of inflammatory diseases through nasal administration.

✦ Generated by Eureka AI based on patent content.

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Abstract

Preservative-free compositions comprising a complex of a corticosteroid and HPBCD for the treatment or prevention of an inflammatory disease through nasal administration.
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Citation Information

Patent Citations

  • INHALABLE COMPOSITIONS COMPRISING AN HPBCD AND BUDESONIDE OR CICLESONIDE COMPLEX FOR THE TREATMENT OR PREVENTION OF A VIRAL RESPIRATORY DISEASE

    BE1029585B1

  • Modulation of virus-host cell interactions using cyclic oligosaccharides

    EP0423240B1

  • Use of cyclodextrin for treatment and prevention of bronchial inflammatory diseases

    EP1799231A1

  • Means to solubilise steroids for inhalation

    EP1894559A1

  • Composition comprising cyclodextrin and budesonide derivatives for the treatment and prophylaxis of pulmonary inflammations

    EP3151836A2