Biodegradable magnesium alloy bile duct litholysis knitted bracket and preparation method thereof

Abstract

The invention belongs to the field of biomedicine, high molecular materials and magnesium alloy materials, and relates to a biodegradable magnesium alloy bile duct litholysis knitted bracket and a preparation method thereof. A knitted bracket is manufactured by knitting magnesium or magnesium alloy into a porous net structured or spiral tubular structured duct; and sodium cholate or / and edetate disodium containing biodegradable polymer layers is / are coated on the inner and outer surfaces of the knitted bracket to obtain the biodegradable magnesium alloy bile duct litholysis knitted bracket. Clinical using results indicate that the bracket provided by the invention is good in radial support property, capable of keeping bile duct unobstructed, capable of being degraded in a certain time to disappear and free of taking out once again; the biocompatibility is good and nearly no inflammation is generated due to in-vivo activities; and at the same time, through the sodium cholate or / and edetate disodium released by the medicine containing polymer coatings, formed stones can be dissolved and prevented from reforming.

Description

technical field

[0001] The invention belongs to the fields of biomedicine, biopolymer materials and magnesium alloy materials, and relates to a biodegradable magnesium alloy bile duct litholytic braided stent and a preparation method thereof, in particular to a drug-loaded coating biodegradable stent for treating bile duct stones and preparation method. Background technique

[0002] According to clinical medical statistics, bile duct stones have a very high incidence rate. The traditional treatment method mainly adopts surgery, but the trauma is large, the complications are many, and the recurrence rate is high; Other diseases and cannot tolerate surgical treatment. In recent years, with the development of endoscopic technology, endoscopic pancreaticobiliary interventional stone removal technology (ERCP technology) has gradually become the main treatment method for bile duct stones, and has achieved good therapeutic effects. However, for some patients with difficult to rem...