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Flexible nano-liposome freeze-dried powder prepared by cistanche tubulosa extract phenylethanoid glycosides and preparation method thereof

A technology of Cistanche deserticola extract and nano-liposome, which is applied in the directions of pharmaceutical formulations, cosmetic preparations, cosmetic preparations, etc., can solve the problem that liposome particle phospholipids are easily oxidized, active substances are leaked, and the application of liposomes is restricted. and other problems to achieve the effect of prolonging the action time, improving the encapsulation rate and improving the transdermal absorption effect.

Active Publication Date: 2015-12-02
THE FIRST TEACHING HOSPITAL OF XINJIANG MEDICAL UNIVERCITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

(5) Good stability: long-term storage of liposome solutions will have many problems, such as leakage of active substances, aggregation of liposome particles, and easy oxidation of phospholipids in a liquid state. Application in Cosmetics

Method used

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  • Flexible nano-liposome freeze-dried powder prepared by cistanche tubulosa extract phenylethanoid glycosides and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1: The Cistanche cistanche extract phenethyl alcohol total glycoside flexible nanoliposome freeze-dried powder, the raw materials include 1 to 10 parts by weight of Cistanche cistanche extract phenethyl alcohol total glycoside, and 60 to 140 parts of eggs Phospholipids, 10 parts to 90 parts of cholesterol, 10 parts to 120 parts of surfactants, Cistanche deserticola extract phenethyl alcohol total glycosides flexible nanoliposome freeze-dried powder is obtained according to the following preparation method: Add an organic solvent to the amount of lecithin and cholesterol until the lecithin and cholesterol are completely dissolved in the organic solvent to obtain a dissolving solution; in the second step, the dissolving solution is evaporated under reduced pressure, and a thin film appears during the evaporation of the dissolving solution under reduced pressure At this time, add the organic mixed solution to the dissolving solution until the oil phase is obtained af...

Embodiment 2

[0023] Example 2: The Cistanche cistanche extract phenethyl alcohol total glycoside flexible nanoliposome freeze-dried powder, the raw materials include 1 part or 10 parts of Cistanche cistanche extract phenethyl alcohol total glycoside, 60 parts or 140 parts egg Phospholipids, 10 parts or 90 parts of cholesterol, 10 parts or 120 parts of surfactants, Cistanche spp. extract phenethyl alcohol total glycosides flexible nanoliposome lyophilized powder is obtained according to the following preparation method: Add an organic solvent to the amount of lecithin and cholesterol until the lecithin and cholesterol are completely dissolved in the organic solvent to obtain a dissolving solution; in the second step, the dissolving solution is evaporated under reduced pressure, and a thin film appears during the evaporation of the dissolving solution under reduced pressure At this time, add the organic mixed solution to the dissolving solution until the oil phase is obtained after the film i...

Embodiment 3

[0024] Example 3: The cistanche extract phenethyl alcohol total glycoside flexible nanoliposome freeze-dried powder, the raw materials include 6 to 10 parts by weight of the cistanche extract phenethyl total glycoside, and 80 to 100 parts egg Phospholipids, 60 parts to 90 parts of cholesterol, 80 parts to 110 parts of surfactants, Cistanche deserticola extract phenylethanol total glycosides flexible nanoliposome lyophilized powder is obtained according to the following preparation method: Add an organic solvent to the amount of lecithin and cholesterol until the lecithin and cholesterol are completely dissolved in the organic solvent to obtain a dissolving solution; in the second step, the dissolving solution is evaporated under reduced pressure, and a thin film appears during the evaporation of the dissolving solution under reduced pressure At this time, add the organic mixed solution to the dissolving solution until the oil phase is obtained after the film is dissolved; the th...

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Abstract

The invention relates to the technical field of flexible nano-liposome freeze-dried powder and a preparation method thereof, in particular to flexible nano-liposome freeze-dried powder prepared by cistanche tubulosa extract phenylethanoid glycosides and a preparation method thereof. In preparation, the flexible nano-liposome freeze-dried powder prepared by cistanche tubulosa extract phenylethanoid glycosides comprises the raw materials of the cistanche tubulosa extract phenylethanoid glycosides, lecithin, cholesterin and sodium cholate. Cistanche tubulosa extract phenyylethanoid glycosides are prepared into the nano-liposome freeze-dried powder for the first time, the transdermal absorption effect of cistanche tubulosa extract phenylethanoid glycosides is improved, meanwhile, the action time of cistanche tubulosa extract phenylethanoid glycosides is prolonged, and according to the features that the flexible nano-liposome freeze-dried powder prepared by cistanche tubulosa extract phenylethanoid glycosides has good encapsulation efficiency and is small in particle size and good in stability, technical bases are provided for development of cosmetics or related products with cistanche tubulosa extract phenylethanoid glycosides being main components at the later period.

Description

technical field [0001] The invention relates to the technical field of flexible nano-liposome freeze-dried powder and a preparation method thereof, and relates to a flexible nano-liposome freeze-dried powder of phenylethanol total glycosides extracted from the genus Cistanche and a preparation method thereof. Background technique [0002] Cistanche is one of the most distinctive and advantageous medicinal resources in Xinjiang. Many ancient Chinese medicine documents have recorded that Cistanche has the effect of pleasing and beautifying the skin. Studies have shown that the whitening and sunscreen effects of phenylethanol glycosides extracted from Cistanche deserticola are mainly related to the following factors: (1) Inhibition of tyrosinase activity and reduction of melanin formation. Tyrosinase is the rate-limiting enzyme that catalyzes the production of melanin in melanocytes. The total phenylethanol glycosides of Cistanche deserticola can penetrate into the skin, and ca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/02A61K8/97A61Q19/02
CPCA61K8/14A61K8/97A61Q19/02
Inventor 杨建华胡君萍许欢欢居博伟吴姗姗朱丹丹曹丹丹
Owner THE FIRST TEACHING HOSPITAL OF XINJIANG MEDICAL UNIVERCITY
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