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Suspensoid powder injection of amoxicillin sodium sulbactam sodium medicine composition and novel application thereof

A technology of amoxicillin sodium sulbactam sodium and amoxicillin sodium is applied in the field of amoxicillin sodium sulbactam sodium pharmaceutical composition suspension powder injection and preparation thereof, and can solve the problems of enhancing, amoxicillin sodium and sulbactam sodium. The problem of poor stability of sodium tannamide can improve the stability, improve the therapeutic index of the drug, and improve the bioavailability.

Inactive Publication Date: 2010-01-27
HAINAN YONGTIAN PHARMA INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] The combined preparation of amoxicillin sodium and sulbactam sodium of the present invention is made into a powder injection by freeze-drying using emulsification suspension technology, which not only solves the problem of poor stability of amoxicillin sodium and sulbactam sodium, but also greatly enhances the It is for the treatment of prostatitis, has thus completed the present invention

Method used

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  • Suspensoid powder injection of amoxicillin sodium sulbactam sodium medicine composition and novel application thereof
  • Suspensoid powder injection of amoxicillin sodium sulbactam sodium medicine composition and novel application thereof
  • Suspensoid powder injection of amoxicillin sodium sulbactam sodium medicine composition and novel application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] The preparation of embodiment 1 amoxicillin sodium sulbactam sodium suspension powder injection

[0049] Prescription (100 bottles):

[0050] Amoxicillin Sodium 25g

[0051] Sulbactam Sodium 12.5g

[0052] Tween 80 75g

[0053] Cholesterol 37.5g

[0054] Sodium deoxycholate 12.5g

[0055] Mannitol 31.25g

[0056] Glucose 31.25g

[0057] Preparation Process

[0058] (1) Add 75g of Tween 80, 37.5g of cholesterol and 12.5g of sodium deoxycholate into 1100ml of water for injection, then add 25g of amoxicillin sodium and 12.5g of sulbactam sodium and mix well, heat and stir in a water bath at 70°C until molten state;

[0059] (2) Heat the above liquid at 70-90°C and use a tissue masher to shear and stir for 15 minutes at a speed of 13000r / min to obtain a primary emulsion, and then circulate and emulsify it through a high-pressure homogenizer for 5 times to obtain an emulsion;

[0060] (3) Add 31.25g of mannitol and 31.25g of glucose to the emulsion, dissolve, filte...

Embodiment 2

[0070] Embodiment 2 Preparation of Amoxicillin Sodium Sulbactam Sodium Suspension Powder Injection

[0071] Prescription (100 bottles):

[0072] Amoxicillin Sodium 50g

[0073] Sulbactam Sodium 25g

[0074] Tween 80 300g

[0075] Cholesterol 150g

[0076] Sodium deoxycholate 150g

[0077] Sorbitol 375g

[0078] Lactose 125g

[0079] Preparation Process

[0080] (1) Add 300g of Tween 80, 150g of cholesterol and 150g of sodium deoxycholate into 4000ml of water for injection, then add 50g of amoxicillin sodium and 25g of sulbactam sodium and mix evenly, heat and stir in a water bath at 90°C until molten;

[0081] (2) Keeping the above liquid at 70-90°C for 20 minutes with a tissue masher to shear and stir at a speed of 10,000 r / min to obtain a primary emulsion, and then circulate and emulsify it through a high-pressure homogenizer for 4 times to obtain an emulsion;

[0082] (3) Add 375g of sorbitol and 125g of lactose to the emulsion, dissolve, filter, subpackage, and f...

Embodiment 3

[0093] Example 3 Preparation of Amoxicillin Sodium Sulbactam Sodium Suspension Minute Injection

[0094] Prescription (100 bottles):

[0095] Amoxicillin Sodium 100g

[0096] Sulbactam Sodium 50g

[0097] Tween 80 300g

[0098] Cholesterol 300g

[0099] Sodium deoxycholate 50g

[0100] Trehalose 800g

[0101] Sodium chloride 200g

[0102] Preparation Process

[0103] (1) Add 300g of Tween 80, 300g of cholesterol and 50g of sodium deoxycholate into 7500ml of water for injection, then add 100g of amoxicillin sodium and 50g of sulbactam sodium and mix evenly, heat and stir in a water bath at 80°C until molten;

[0104] (2) Keeping the above liquid at 70-90°C for 10 minutes with a tissue masher to shear and stir at a speed of 15,000 r / min to obtain a primary emulsion, and then circulate and emulsify it through a high-pressure homogenizer for 5 times to obtain an emulsion;

[0105] (3) Add 800 g of trehalose and 200 g of sodium chloride to the emulsion, dissolve, filter, ...

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Abstract

The invention relates to suspensoid powder injection of an amoxicillin sodium sulbactam sodium medicine composition and a preparation method thereof. The suspensoid powder injection contains Tween 80, cholesterol, deoxysodium cholate, a freeze-drying support agent and active components. The invention also relates to a novel application of the suspensoid powder injection in preparing a medicine treating prostatitis further.

Description

technical field [0001] The invention relates to a new dosage form and new application of amoxicillin sodium sulbactam sodium, in particular to amoxicillin sodium sulbactam sodium pharmaceutical composition suspension powder injection and a preparation method thereof. Background technique [0002] Prostatitis is a frequently-occurring and common disease of the male urinary system. Its etiology can be primary or secondary to tissues and organs, and it is also related to infection and verification. Among them, chronic prostatitis is regarded as a clinical disease characterized by abnormal urination and other symptoms formed under the action of infection or non-infection factors. Since the etiology of non-infectious prostatitis is not clear, it is suggested that there are various factors causing prostatitis and their mechanisms of action are complex. In recent years, people have noticed that the physical and mental fatigue caused by stress load and the long-term congestion of t...

Claims

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Application Information

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IPC IPC(8): A61K31/43A61K9/19A61J3/02A61P13/08
Inventor 王明
Owner HAINAN YONGTIAN PHARMA INST
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