Mouth spray for preventing and treating nausea and emesis after tumor chemotherapy and radiotheraphy and preparation method thereof

A technology of oral spray, chemotherapy and radiotherapy, applied in the field of pharmaceutical preparations, to achieve the effects of dose control, simple operation, and easy dose

Inactive Publication Date: 2009-03-18
陆飚 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] However, due to various reasons such as the formulation complexity and stability of oral spray preparations for preventing and treating chemothera

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Dissolve 500-1000g of palonosetron hydrochloride in 8000-9000g of sodium citrate buffer solution, and mix 250-500g of water-soluble azone, 250-500g of propylene glycol under constant stirring (200±100 rpm). , 0.2-2g sodium saccharin and 10-20g lysostaphin are added slowly, and stirring is continued for 10-60 minutes after the addition is completed.

Embodiment 2

[0033] Dissolve 500-1000g of granisetron in 8000-9000g of sodium citrate buffer, under constant stirring (200±100 rpm), add 250-500g of water-soluble azone, 250-500g of propylene glycol, 0.2- Add 2g of sodium saccharin and 10-20g of lysostaphin slowly, and continue stirring for 10-60 minutes after the addition is complete.

Embodiment 3

[0035] Dissolve 500-1000g of ondansetron in 8000-9000g of sodium citrate buffer solution, and mix 250-500g of water-soluble azone, 250-500g of propylene glycol, 0.2 Slowly add ~2g sodium saccharin and 10~20g lysostaphin, and continue stirring for 10~60 minutes after adding.

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PUM

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Abstract

The invention relates to an oral spray for controlling nausea and vomit of chemotherapy and radiation therapy, the formula of the oral spray is composed of ingredients with the following parts by weight: 5-50 parts of drug absorption enhancer, 2-20 parts of drug active ingredient and 30-90 parts of buffer, the drug absorption enhancer can be any one or the combination of more of the following ingredients: azone, propylene glycol, polysorbate (Tween), ethylene glycol deoxycholic acid sodium salt, brij, sodium decanoate, lauric acid, stearic acid, sodium lauryl sulphate, stearyl alcohol sodium sulfate, dioctyl succinate sodium sulfonate, oleic acid, GK2, menthol and borneol; the drug active ingredient can be any one combination of the following ingredients: palonosetron hydrochloride, granisetron, ondansetron, azasetron and tropisetron; and the ingredients of the buffer are sodium citrate buffer solution and phosphate buffer solution. The oral spray provides a formulation which is safer, painless and convenient for patients with advanced tumor, elderly and weak patients, children patients and the patients who suffer from the metal illness and do not obey the oral administration or the injection drug administration.

Description

technical field [0001] The invention relates to pharmaceutical preparations in the field of medicine, in particular to formulations and preparations of oral spray preparations for preventing and treating nausea and vomiting caused by tumor chemotherapy and radiotherapy. The invention can be used to prevent and treat adverse reactions such as bad habits and vomiting caused by chemotherapy or radiotherapy in tumor patients. The present invention is suitable for tumor chemotherapy and radiotherapy patients, and is especially suitable for elderly patients, infant patients, critically ill patients, dysphagia patients and advanced tumor patients among tumor patients. technical background [0002] Tumor has become the number one killer threatening human health. Chemotherapy, surgery, and radiotherapy are the most important means of treating tumor diseases. An important and common complication in cancer therapy, almost all chemotherapeutic agents have emetogenic potential. Severe...

Claims

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Application Information

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IPC IPC(8): A61K9/12A61K47/12A61K47/14A61K47/10A61K31/4178A61K31/473A61K31/46A61K31/439A61P35/00
Inventor 陆飚黄锡桂
Owner 陆飚
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