Application of CAP-activated saline in aspects of cell metabolism regulation and tumor treatment and medicine

Abstract

The invention discloses application of cold atmospheric plasma (CAP)-activated saline in the aspects of cell metabolism regulation and tumor treatment and a medicine. The saline is activated by using a cold atmospheric pressure plasmas technology, the activated saline acts on an in-vivo tumor, and the research conclusion comprises that active particles such as ROS and RNS of the CAP-activated saline cause change of the metabolic level of tumor cells (especially glycerophospholipid metabolic regulation), the in-vivo tumor can be ablated, and no toxic or side effect exists basically. Metabolite capable of generating up-regulation through metabolic regulation of glycerophospholipid is 3-acetyl-2, 5-dimethylthiophene and DL-glutamic acid, and metabolite capable of generating down-regulation is 5-methylcytidine, N2, N2-dimethyl guanosine, L-histidine and 1-methyl guanosine. Therefore, glycerophospholipid metabolism regulation drugs, tumor treatment drugs and the like can be prepared, and drug units can be packaged at proper doses.

Description

technical field [0001] The invention relates to a drug for regulating cell metabolism and a broad-spectrum drug for treating tumors. Background technique [0002] In physics, plasma is defined as the fourth state of matter in addition to solid, liquid, and gas, the plasma state. According to the gas temperature of the plasma, the plasma can be divided into high temperature plasma (10 9 K) and low temperature plasma (<10 3 K), low-temperature plasma is divided into thermal equilibrium plasma and non-thermal equilibrium plasma, wherein the non-thermal equilibrium plasma, that is, atmospheric pressure cooling plasma (cold atmospheric pressure plasma, CAP), the macroscopic temperature is close to room temperature and can be produce. [0003] In the past two decades, CAP technology has risen rapidly. It can be generated under atmospheric pressure through gas high-voltage discharge, and contains various components such as ultraviolet photons, charged particles, metastable pa...

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Problems solved by technology

[0004] In the past five years, low-temperature atmospheric plasma-activated liquids (cold atmospheric plasma-activated liquids, PAL) have shown promising application prospects in cancer therapy, similar to common direct CAP therapy, PAL showed both in vivo and in vitro It has selective anti-cancer ability, and PAL can also be injected into or near deep tumor sites as a drug, can be stored for a long time, and can be used without relying on CAP devices, which significantly broadens the application range of CAP technology, and PAL There is no report on the mechanism of action of tumors in vivo, and it is unknown whether PAL can have other applications in medicine

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