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Biomarkers and method for predicting premature rupture of fetal membranes

A biomarker, a technology for premature rupture of membranes, which is applied in the field of markers for predicting premature rupture of membranes, and can solve the problems of inability to be used as an absolute indicator for diagnosing premature rupture of membranes, false positives, and reduced accuracy.

Active Publication Date: 2021-04-30
BEIJING CHAOYANG HOSPITAL CAPITAL MEDICAL UNIV +1
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AI Technical Summary

Problems solved by technology

Amniotic fluid index (≤7cm) is used as the standard for diagnosing premature rupture of membranes. The sensitivity is only 30.0%, the specificity is 91.8%, and the accuracy is 62.0%. Studies have shown that the accuracy of ultrasonic quantitative amniotic fluid index in diagnosing premature rupture of membranes is low and cannot be used as a standard. Absolute indicator for diagnosing premature rupture of membranes, it can only be used as an auxiliary diagnostic indicator
Especially when the membranes are ruptured, the amniotic fluid is likely to be contaminated by cervical mucus, blood or vaginal secretions, which reduces the accuracy of traditional detection methods, leading to false positive or false negative diagnoses, thus delaying treatment or triggering more obstetrical interventions measure

Method used

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  • Biomarkers and method for predicting premature rupture of fetal membranes

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Embodiment

[0033] Reagent acetonitrile, methyl alcohol (chromatographically pure) used in the method of the present invention are purchased from Fisher Scientific company, formic acid (chromatographically pure) is purchased from Merck company, methyl tert-butyl ether (MTBE), chloroform (analytical pure) are purchased from Nanjing Chemical Reagent Co., Ltd., the experimental water is Wahaha purified water (Hangzhou Wahaha Co., Ltd.). All other chemical reagents were of analytical grade or higher.

[0034] The method for predicting premature rupture of membranes based on the biomarker of the present invention specifically includes:

[0035] 1. Establish standard procedures for the implementation of metabolomics clinical research in predicting premature rupture of membranes. All recruited volunteers were Chinese Han pregnant women, and prenatal files had been established before recruitment.

[0036] 1.1 Inclusion criteria for the premature rupture of membranes group: aged 20-45 years, wit...

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Abstract

The invention discloses a biomarker and a method for predicting premature rupture of fetal membranes, and the biomarker is selected from one or more of 4-methylvaleraldehyde (isohexanal), sphingolipids (SP) metabolite, glycerolipids (GL) metabolite and glycerophospholipids (GP) metabolite; the biomarker has a change in content difference multiple between a pregnant female body and a healthy pregnant female body at risk of premature rupture of fetal membranes. The biomarker for predicting premature rupture of fetal membranes and the prediction method have important significance for early prediction of premature rupture of fetal membranes before delivery and formulation of corresponding intervention measures.

Description

technical field [0001] The present invention relates to a marker for predicting premature rupture of membranes. More specifically, the present invention relates to a biomarker and method for predicting premature rupture of membranes. Background technique [0002] Premature rupture of membranes (PROM) refers to the spontaneous rupture of membranes more than 24 hours before labor. It is one of the common perinatal complications, with an incidence rate of 2.7% to 7.0%. Infection, premature labor, placental abruption, fetal distress, etc. occur. Long-term rupture of membranes is closely related to maternal and fetal complications and death caused by surgical risks, and seriously endangers the life and health of pregnant women and fetuses. Therefore, early prediction of premature rupture of membranes before labor and the formulation of corresponding intervention measures are of great significance . [0003] The cause and specific mechanism of premature rupture of membranes are...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/72G01N30/86
CPCG01N30/02G01N30/72G01N30/8631
Inventor 刘丽宏安卓玲赵瑞刘燕萍马良坤
Owner BEIJING CHAOYANG HOSPITAL CAPITAL MEDICAL UNIV
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