12 results about "Foetal membranes" patented technology

The invention belongs to the technical field of obstetrics and gynecology disease prediction, and particularly relates to a premature fetal membrane premature rupture prediction marker based on maternal circulation exosome microRNA and an application kit. According to the invention, placentas, fetal membranes and plasma exosomes of pregnant women with full-term birth and premature birth premature rupture of fetal membranes are collected for sequencing, the fetal membrane-derived exosome hsa-miR-145-3p which can be detected in the plasma exosomes is screened out in combination with a verification set, and the cell source and the premature birth promoting effect of the fetal membrane-derived exosome hsa-miR-145-3p are respectively clarified at a cell level and an animal level; and finally, by detecting the level of the plasma exosome hsa-miR-145-3p of the pregnant 12 (+ 1)-17 (+ 6) perimaternal body, the efficiency (AUC = 0.833) of the exosome in predicting the occurrence of premature rupture of fetal membranes in premature delivery is illustrated. According to the method, the high-risk crowd of the pPROM can be predicted through a noninvasive method in the early and middle stages of pregnancy, and the method has guiding significance for subsequent prevention and intervention of the high-risk crowd.

The invention discloses a blood mtDNACN-based system, method and application for evaluating an adverse pregnancy outcome risk, and the system comprises a data obtaining module which is used for obtaining blood mtDNACN detection data; the risk assessment module is used for storing a pre-constructed causal risk assessment model; and the result output module is used for outputting a risk assessment result. The model is constructed based on a Mendel randomization method, SNP significantly related to blood mtDNACN is used as a tool variable, and the lactic acid metabolism level hybrid effect is innovatively corrected, so that the lactic acid metabolism level hybrid effect of a subject is corrected without depending on lactic acid parameters of the subject. The causal association between the blood mtDNACN and the specific adverse pregnancy outcome (including gestational hypertension, preeclampsia, premature rupture of fetal membranes and the like) is accurately determined. According to the scheme provided by the invention, more reliable and anti-hybrid individualized risk assessment can be realized, and a new tool is provided for health management in the gestation period.

The invention provides an intelligent prediction system and method for prenatal complications of an obstetrical department based on multi-modal fusion of sclera characteristics and clinical indexes, and is applied to the technical field of data processing. The method comprises the following steps: performing preprocessing and fusion calculation on feature information in multi-modal data to generate fusion calculation data; the prenatal complications (such as gestational diabetes mellitus, gestational hypertension, premature rupture of fetal membranes and premature delivery) of the obstetrics department are dynamically predicted, and prediction characteristic parameters are generated; performing abnormal value filtering processing on the cross-modal feature weight, dynamically optimizing the weight in combination with a clinical and image feature correlation matrix, and generating feature weight data; processing the feature weight data to generate feature importance dynamic change data and abnormal features; processing the feature importance dynamic change data based on a preset risk judgment rule and the abnormal features to generate risk judgment data; and processing the risk judgment data and the prediction characteristic parameters to generate risk early warning information and a complication intervention instruction.

This invention provides a dual-segment, dual-color pH comparison catheter for clinical identification of premature rupture of membranes, belonging to the field of medical catheter technology. It includes a main catheter tube with a urine segment pH membrane and an amniotic fluid segment pH membrane sequentially arranged along the axial direction on the anterior outer wall of the main tube. The urine segment pH membrane has a color development range of pH 5.5-6.5, and its color change is a continuous gradient from yellow to green. This invention achieves zero-sampling detection under sterile conditions, highly integrating pH identification function into routine catheterization procedures. The pH value of urine and any potentially mixed amniotic fluid is simultaneously detected upon catheter insertion into the bladder, without the need for vaginal speculum, sampling swabs, or any form of secondary sterile opening. This design completely blocks the path of exogenous bacteria into the maternal reproductive tract at a physical level, thereby fundamentally and effectively reducing the incidence of clinically common chorioamnionitis and urinary tract infections, and improving perinatal medical safety and quality.

A hip lifting bolster for premature rupture of fetal membranes relates to the technical field of hip lifting and comprises a lifting assembly, a collecting assembly and a cushion cover, the lifting assembly comprises a bottom plate and an inclined plate arranged at the top of the bottom plate, the collecting assembly comprises a box body and a movable plate arranged at the top of the box body, and a flow guide opening penetrating through the movable plate is formed in the movable plate. The flow guide opening is located in the bottom of the vagina of the pregnant woman and used for guiding flowing-out amniotic fluid into the box body, and the cushion sleeve is sleeved outside the lifting assembly and the collecting assembly. The collecting assembly is located at the bottom of the vagina of the pregnant woman and used for containing amniotic fluid flowing out of the vagina of the pregnant woman, meanwhile, the cushion cover absorbs the falling amniotic fluid, the amount of the amniotic fluid flowing to a sickbed is reduced, discomfort of the pregnant woman is reduced, and the cleaning workload of medical staff is reduced.

A device for making an amniotic cavity access through a mother and method thereof is disclosed, which includes a transvaginal fetal membrane puncture assembly configured to construct the amniotic cavity access through a natural orifice of a maternal vagina, a trans maternal abdominal wall uterine fetal member puncture assembly configured to construct the amniotic cavity access through the maternal abdominal wall and / or a belly button, and an amniotic cavity combined sheath configured to form the amniotic cavity access for placing a fetus positioning surgical robotic arm and / or surgical instruments, thereby providing a safe operation channel for the implementation of an intrauterine fetal minimally invasive surgery.

The utility model relates to the technical field of medical instruments, in particular to a fetal membrane puncturing device for gynaecology and obstetrics, which comprises a connecting handle, the front end of the connecting handle is rotatably connected with a rotating handle, a pushing rod is arranged in the connecting handle in a sliding and penetrating mode, one end of the pushing rod extends into the rotating handle, and an external thread is arranged on the surface of the end portion of the pushing rod. And an internal thread matched with the rotating handle is arranged in the rotating handle. By adding a thread matching mechanism of the rotating handle and the pushing rod, accurate control over the feeding amount and the puncturing depth of the membrane rupturing needle is achieved, the risk caused by too deep puncturing to a fetus is reduced, the stability and accuracy of operation are remarkably improved, the uncertainty caused by manual operation is reduced, and therefore the safety of the membrane rupturing process is improved.

This invention discloses the application of MIF gene silencing in the preparation of drugs for treating premature rupture of membranes (PPROM), belonging to the fields of biomedicine and molecular biology. By collecting fetal membrane tissues from patients with PPROM and normal controls, this invention found that the expression level of MIF protein and the concentration of PGE2 were significantly increased in the PPROM group. Further investigation using siRNA technology to silence the MIF gene in human amniotic epithelial cells revealed that MIF silencing significantly reduced PGE2 levels. This invention is the first to demonstrate that MIF gene silencing can effectively treat PPROM by reducing PGE2 (inhibiting uterine contractions). This invention also provides a pharmaceutical composition containing MIF siRNA. This invention provides a novel molecular target and therapeutic strategy for the treatment of PPROM, with broad clinical application prospects.

The invention discloses a system and a method for evaluating premature rupture risk of fetal membranes based on leukocyte telomere length and application, the system comprises a data acquisition module, a data storage module, an analysis processing module and an output module, and covariant data such as leukocyte telomere length measurement value, age and educational level of a pregnant woman to be evaluated are acquired; and calculating a risk level by using a pre-constructed risk assessment model. According to the method, the nonlinear reverse J-type positive correlation between LTL and the premature rupture (PROM) risk is found and confirmed for the first time, a key risk turning threshold value is determined, and a quantitative risk grading system based on quartile is constructed. A brand-new non-invasive early screening tool is provided, objective and quantitative evaluation results can be obtained, early recognition of high-risk pregnant women is facilitated, timely intervention is achieved, and therefore the incidence rate of PROM and complications of PROM is reduced.

This invention relates to and discloses an amniotic fluid drainage device for obstetrics, comprising an outer cylinder and an inner cylinder that are hollow inside and open at both ends. The inner cylinder has a first end and a second end, with the first end slidably disposed within the inner cavity of the outer cylinder. A drainage needle is disposed within the inner cylinder and slidably disposed along the length of the inner cylinder, with the second end of the drainage needle protruding outside the inner cylinder. A positioning mechanism is provided on the inner cylinder. Through the cooperation of the positioning mechanism, the inner cylinder, the outer cylinder, and the drainage needle, the outer cylinder provides protection for the inner cylinder. Before amniotic fluid drainage, the positioning mechanism is used to attach the first end of the inner cylinder to the pregnant woman's abdomen or fetal membranes, preventing the inner cylinder from slipping relative to the smooth skin or fetal membranes. This ensures that the inner cylinder is always in the predetermined puncture position, thereby reducing the difficulty of the drainage operation. Furthermore, when using the drainage needle to puncture the skin and / or fetal membranes, the fixation of the inner cylinder ensures that the drainage needle does not slip, thereby reducing the difficulty of puncture and avoiding secondary injury to the pregnant woman.

A fetal intrauterine positioning fixation device is configured for entering an amniotic cavity through a vaginal cervical fetal membrane access and / or abdominal wall uterine fetal membrane access to adjust and fix a fetal position in a maternal uterus. The fetal intrauterine positioning fixation device includes a manipulator, a mechanical arm and a surgical robot, the manipulator and mechanical arm can enter an amniotic cavity through a vaginal cervical fetal membrane channel or abdominal wall uterine fetal membrane channel, so that a doctor can control the manipulator and mechanical arm through the surgical robot or a handle to identify a fetus, adjust a fetal position and fix the fetus according to a preoperative planning, and monitor a fetal status in real time, expose a surgical treatment area, and create an operation space for implementing intrauterine fetal surgery.

The invention relates to a device to be used for closing a tissue opening in a tissue. In particular, the present invention relates to a device used for a closing an opening in a membrane such as a fetal membrane by stitching in a minimally invasive procedure.