The invention discloses a manufacturing method of a small prefabricated box girder. The manufacturing method includes the following steps that firstly, a pedestal is prefabricated; secondly, mold plates are installed, wherein the mold plates are installed in the following sequence of bottom mold installation, side mold installation, inner mold installation, end mold installation and flange plate installation on side molds; thirdly, concrete is poured and cured; fourthly, demolding is conducted, wherein demolding includes detaching of end molds at the two ends of a girder body, inner mold demolding and side mold demolding; and fifthly, the girder body is cured. According to the manufacturing method, fully-hydraulic actions are achieved through the outer mold plates, the use effect is improved greatly, and labor intensity is lowered; and semi-automation is achieved through an inner mold, quick demolding and mold combination of the mold plates are facilitated, the operation intensity of workers in small space in the girder body is lowered, and the potential safety hazards of working under the high temperature are reduced. The mold plates are firm and general in structure, quick and convenient to use and advanced in design manufacturing and construction process idea.